Controlled release of dexamethasone from porous PLGA scaffolds under cyclic loading

Science China Chemistry

Volumn 53, Issue 3, 2010, Pages 594-598

  Tang, Gong Wen ^a   Yang, Yan Fang ^a   Sun, Ai Ping ^a   Song, Tian Tian ^a   Zhao, Yun Hui ^a   Yuan, Xu Bo ^a   Yuan, Xiao Yan ^a   Fan, Yu Bo ^b   Wang, Min ^c  

^a TIANJIN UNIVERSITY   (China)

^b BEIHANG UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cyclic loading; Dexamethasone; Microsphere; PLGA; Scaffold

Indexed keywords

CLINICAL EFFICACY; CONTROLLED RELEASE; CYCLIC LOADINGS; DEXAMETHASONE; DEXAMETHASONES; DRUG RELEASE; DRUG-RELEASE RATE; IN-VIVO; KEY FACTORS; MECHANICAL ENVIRONMENT; PLGA SCAFFOLDS; PLLA; POLY (L-LACTIDE); POLY(LACTIC-CO-GLYCOLIC ACID); POROGEN LEACHING; SCAFFOLD FABRICATION; SEEDING TECHNIQUES; THERMALLY INDUCED PHASE SEPARATION; TISSUE ENGINEERING SCAFFOLD; ULTRAVIOLET VISIBLE SPECTROPHOTOMETER; WATER BATHS;

CONTROLLED DRUG DELIVERY; CYCLIC LOADS; CYTOTOXICITY; DISSOLUTION; ETHYLENE; ETHYLENE GLYCOL; LEACHING; LOADING; MICROSPHERES; MORPHOLOGY; PHASE SEPARATION; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMER BLENDS; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING;

SCAFFOLDS;

EID: 77950927552     PISSN: 16747291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11426-010-0074-3     Document Type: Article

References (13)

1. Lee SH, Shin H. Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Adv Drug Deliv Rev, 2007, 59 (4-5) : 339-359 (Pubitemid 46879973)
2. Rosso F, Giordano A, Barbarisi M, Barbarisi A. From cell-ECM interactions to tissue engineering. J Cell Physiol, 2004, 199(2):174-180 (Pubitemid 38436743)
3. Biondi M, Ungaro F, Quaglia F, Netti PA. Controlled drug delivery in tissue engineering. Adv Drug Deliv Rev, 2008, 60(2):229-242 (Pubitemid 350236401)
4. Yoon JJ, Kim JH, Park TG. Dexamethasone-releasing biodegradable polymer scaffolds fabricated by a gas-foaming/salt-leaching method. Biomaterials, 2003, 24(13):2323-2329
5. Kim HD, Valentini RF. Human osteoblast response in vitro to platelet-derived grow& factor and transforming growth factor-β de-livered from controlled-release polymer rods. Biomaterials, 1997, 18(17):1178-1184
6. Kanematsu A, Yamamoto S, Ozeki M, Noguchi T, Kanatani I, Ogawa O, Tabata Y. Collagenous matrices as release carriers of exogenous growth factors. Biomaterials, 2004, 25(18):4513-4520 (Pubitemid 38388611)
7. Wei GB, Jin QM, Giannobile WV, Ma PX. Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB. J Control Release, 2006, 112(1):103-110
8. Jaklenec A, Hinckfuss A, Bilgen B, Ciombor DM, Aaron R, Mathiowitz E. Sequential release of bioactive IGF-I and TGF-β from PLGA microsphere-based scaffolds. Biomaterials, 2008, 29(10):1518-1525
9. Niu XF, Feng QL, Wang MB, Guo XD, Zheng QX. Porous nano-HA/collagen/PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2. J Control Release, 2009, 134(2):111-117
10. Kim H, Kim HW, Suh H. Sustained release of ascorbate-2-phosphate and dexamethasone from porous PLGA scaffolds for bone tissue engineering using mesenchymal stem cells. Biomaterials, 2003, 24(25):4671-4679 (Pubitemid 37013628)
11. Duarte ARC, Mano JF, Reis RL. Preparation of chitosan scaffolds loaded with dexamethasone for tissue engineering applications using supercritical fluid technology. Eur Polym J, 2009, 45(1):141-148
12. Yang YF, Zhao J, Zhao YH, Wen L, Yuan XY, Fan YB. Formation of porous PLGA scaffolds by a combining method of thermally induced phase separation and porogen leaching. J Appl Polym Sci, 2008, 109(2):1232-1241
13. Yang YF, Tang GW, Zhao YH, Yuan XY, Fan YB. Effect of cyclic loading on in vitro degradation of poly (L-lactide-co-glycolide) scaffolds. J Biomater Sci Polym Ed, in press