Cyclic intermittent hypoxia enhances renal sympathetic response to ICV ET-1 in conscious rats

Respiratory Physiology and Neurobiology

Volumn 171, Issue 2, 2010, Pages 83-89

  Huang, Jianhua ^a   Xie, Tian ^a   Wu, Yuming ^a,b   Li, Xianghong ^a   Lusina, Sara ^a   Ji, En Sheng ^a,b   Xiang, Shuanglin ^a   Liu, Yuzhen ^a   Gautam, Shiva ^c   Weiss, J Woodrow ^a  

^a Division of Pulmonary and Critical Care Medicine   (United States)

^b HEBEI MEDICAL UNIVERSITY   (China)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Endothelin; Intermittent hypoxia; Intracerebroventricular injection; Subfornical organ; Sympathetic nervous system

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR A; UNCLASSIFIED DRUG; ENDOTHELIN A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYCLIC INTERMITTENT HYPOXIA; HEART RATE; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL SYMPATHETIC RESPONSE; SPRAGUE DAWLEY RAT; SUBFORNICAL ORGAN; SYMPATHETIC TONE; ADRENERGIC SYSTEM; ANIMAL; ANOXIA; BLOOD PRESSURE; CONSCIOUSNESS; DRUG EFFECTS; INNERVATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; KIDNEY; METABOLISM; PATHOPHYSIOLOGY; PERIODICITY; TIME;

ANIMALS; ANOXIA; BLOOD PRESSURE; CONSCIOUSNESS; ENDOTHELIN-1; HEART RATE; INJECTIONS, INTRAVENTRICULAR; KIDNEY; MALE; PERIODICITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; SUBFORNICAL ORGAN; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS;

EID: 77950918560     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2010.03.008     Document Type: Article

References (33)

1. Bao G., Metrevelli N., Li R., Taylor A., and Fletcher E.C. Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system. J. Appl. Physiol. 83 (1997) 95-101
2. Brooks D., Horner R.L., Kimoff R.J., Kozar L.F., Render-Texeira C.L., and Phillipson E.A. Effect of obstructive sleep apnea versus sleep fragmentation on responses to airway occlusion. Am. J. Respir. Crit. Care Med. 155 (1997) 1609-1617
3. Brooks D., Horner R.L., Kozar L.F., Render-Texeira C.L., and Phillipson E.A. Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model. J. Clin. Invest. 99 (1997) 109
4. Brooks V.L., Scrogin K.E., and McKeogh D.F. The interaction of angiotensin II and osmolality in the generation of sympathetic tone during changes in dietary salt intake: an hypothesis. Ann. N.Y. Acad. Sci. 940 (2001) 380-394
5. Campese V.M., Ye S., and Zhong H. Downregulation of neuronal nitric oxide synthase and interleukin-1β mediates angiotensin II-dependent stimulation of sympathetic nerve activity. Hypertension 39 (2002) 519-524
6. Campese V.M., Ye S., Zhong H., Yanamadala V., Ye Z., and Chiu J. Reactive oxygen species stimulate central and peripheral sympathetic nervous system activity. Am. J. Phys. Heart Circ. Physiol. 287 (2004) H695-H703
7. Dampney R.A.L., Horiuchi J., Killinger S., Sherrif M.J., Tan P.S.P., and McDowall L.M. Long-term regulation of arterial pressure by hypothalamic nuclei: some critical questions. Clin. Exp. Pharmacol. Physiol. 32 (2005) 419-425
8. Dampney R.A.L., Horiuchi J., Tagawa T., Fontes M.A.P., Potts P.D., and Polson J.W. Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone. Acta Physiol. Scand. 177 (2003) 209-218
9. DiBona G.F. The sympathetic nervous system and hypertension: recent developments. Hypertension 43 (2004) 147-150
10. Felder R.B., Francis J., Zhang Z.-H., Wei S.-G., Weiss R.M., and Johnson A.K. Heart failure and the brain: new perspectives. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 (2003) R259-R276
11. Fletcher E.C., Bao G., and Miller C.C.I. Effect of recurrent episodic hypocapnic, eucapnic, and hypercapnic hypoxia on systemic blood pressure. J. Appl. Physiol. 78 (1995) 1516-1521
12. Fletcher E.C., Lesske J., Qian W., Miller C.C.I., and Unger T. Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats. Hypertension 19 (1992) 555-561
13. Hla K.M., Young T.B., Bidwell T., Palta M., Skatrud J.B., and Dempsey J. Sleep apnea and hypertension: a population-based study. Ann. Intern. Med. 120 (1994) 382-388
14. Huang J., Tamisier R., Ji E., Tong J., and Weiss J.W. Chronic intermittent hypoxia modulates nNOS mRNA and protein expression in the rat hypothalamus. Respir. Physiol. Neurobiol. 158 (2007) 30-38
15. Kanagy N.L., Walker B.R., and Nelin L.D. Role of endothelin in intermittent hypoxia-induced hypertension. Hypertension 37 Part 2 (2001) 511-515
16. Kurokawa K., Yamada H., and Ochi J. Topographical distribution of neurons containing endothelin type A receptor in the rat brain. J. Comp. Neurol. 389 (1997) 348-360
17. Liu J.-L., Murakami H., and Zucker I.H. Angiotensin II-nitric oxide interaction on sympathetic outflow in conscious rabbits. Circ. Res. 82 (1998) 496-502
18. Liu J.-L., and Zucker I.H. Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II. Circ. Res. 84 (1999) 417-423
19. Ma R., Zucker I.H., and Wang W. Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure. Am. J. Physiol. Heart Circ. Physiol. 276 (1999) H19-H26
20. Palkovits M., Kobayashi R.M., Kizer J.S., Jacobowitz D.M., and Kopin I.J. Effects of stress on catecholamines and tyrosine hydroxylase activity of individual hypothalamic nuclei. Neuroendcrinology 18 (1975) 144-153
21. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 4th ed. (1998), Academic Press, San Diego, CA
22. Patel K.P. Role of paraventricular nucleus in mediating sympathetic outflow in heart failure. Heart Fail. Rev. 5 (2000) 73-86
23. Peppard P.E., Young T., Palta M., and Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N. Engl. J. Med. 342 (2000) 1378-1384
24. Rey S., Corthorn J., Chacon C., and Iturriaga R. Expression and immunolocalization of endothelin peptides and its receptors, ETA and ETB, in the carotid body exposed to chronic intermittent hypoxia. J. Histochem. Cytochem. 55 (2006) 167-174
25. Rey S., Del Rio R., and Iturriaga R. Contribution of endothelin-1 to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia. Brain Res. 1086 (2006) 152-159
26. Rossi N.F., and Chen H. PVN lesions prevent the endothelin 1-induced increase in arterial pressure and vasopressin. Am. J. Physiol. Endocrinol. Metab. 280 (2001) E349-E356
27. Rossi N.F., O'Leary D.S., and Chen H. Mechanisms of centrally administered ET-1-induced increases in systemic arterial pressure and AVP secretion. Am. J. Physiol. Endocrinol. Metab. 272 (1997) E126-E132
28. Rossi N.F., O'Leary D.S., Woodbury D., and Chen H. Endothelin-1 in hypertension in the baroreflex-intact SHR: a role independent from vasopressin release. Am. J. Physiol. Endocrinol. Metab. 279 (2000) E18-E24
29. Wang H., Huang B.S., Ganten D., and Leenen F.H.H. Prevention of sympathetic and cardiac dysfunction after myocardial infarction in transgenic rats deficient in brain angiotensinogen. Circ. Res. 94 (2004) 843-849
30. Wang Y., Liu X.F., Cornish K.G., Zucker I.H., and Patel K.P. Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H205-H213
31. Zhang K., Mayhan W.G., and Patel K.P. Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 273 (1997) R864-R872
32. Zucker I.H. Brain angiotensin II: new insights into its role in sympathetic regulation. Circ. Res. 90 (2002) 503-505
33. Zucker I.H., Schultz H.D., Li Y.F., Wang Y., Wang W., and Patel K.P. The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide. Prog. Biophys. Mol. Biol. 84 (2004) 217-232