Stability of 5-fluoro-2′-deoxycytidine and tetrahydrouridine in combination

AAPS PharmSciTech

Volumn 11, Issue 1, 2010, Pages 247-252

  Guo, Duoli ^a   Myrdal, Paul B ^a   Karlage, Kelly L ^a   O'Connell, Sean P ^a   Wissinger, Travis J ^a   Tabibi, S Esmail ^b   Yalkowsky, Samuel H ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Degradation mechanism; FdCyd; NSC 112907; NSC 48006; THU

Indexed keywords

FLUCYTOSINE DEOXYRIBOSIDE; NSC 48006; TETRAHYDROURIDINE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; DRUG ANTAGONISM; DRUG FORMULATION; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; METABOLITE; PH; PRIORITY JOURNAL; QUANTITATIVE STUDY; SOLID STATE; TEMPERATURE SENSITIVITY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYCYTIDINE; ENZYME INHIBITORS; KINETICS; MICE; TEMPERATURE; TETRAHYDROURIDINE; WATER;

EID: 77950917644     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9383-2     Document Type: Article

References (5)

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5. T Xiang R Niemi P Bummer BD Anderson 2003 Epimer interconversion, isomerization, and hydrolysis of tetrahydrouridine: implications for cytidine deaminase inhibition J Pharma Sci 92 2027 2039 10.1002/jps.10447 1:CAS:528:DC%2BD3sXnvFOms7o%3D (Pubitemid 37175633)