Effect of iron chelator deferasirox on chronic anemia and thrombocytopenia in a transfusion-dependent patient with myelodysplastic syndrome

International Journal of Hematology

Volumn 91, Issue 2, 2010, Pages 333-335

  Nishiuchi, Takamasa ^a   Okutani, Yuichi ^a   Fujita, Toshikazu ^a   Yoshida, Kazuya ^b   Ohnishi, Hiroaki ^c   Haba, Reiji ^c  

^a Mitani Fujita Hospital   (Japan)

^b National Hospital Organization Takamatsu Medical Center   (Japan)

^c KAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEFERASIROX; IRON CHELATING AGENT;

AGED; ANEMIA; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; IRON OVERLOAD; LETTER; LIVER HEMOSIDEROSIS; MYELODYSPLASTIC SYNDROME; REFRACTORY CYTOPENIA WITH MULTILINEAGE DYSPLASIA; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA;

AGED; ANEMIA; BENZOIC ACIDS; BLOOD TRANSFUSION; CHRONIC DISEASE; FEMALE; HUMANS; IRON CHELATING AGENTS; IRON OVERLOAD; MYELODYSPLASTIC SYNDROMES; THROMBOCYTOPENIA; TRIAZOLES;

EID: 77950917096     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-010-0500-5     Document Type: Letter

References (13)

1. M Takatoku T Uchiyama S Okamoto Y Kanakura K Sawada M Tomonaga, et al. 2007 Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality Eur J Haematol 78 487 494 10.1111/j.1600-0609.2007.00842.x 1:CAS:528:DC%2BD2sXotV2gsbc%3D 17391310 (Pubitemid 46753591)
2. K Miyazawa K Ohyashiki A Urabe T Hata S Nakao K Ozawa, et al. 2008 A safety pharmacokinetic and pharmacodynamic investigation of deferasirox (Exjade, ICL670) in patients with transfusion-dependent anemias and iron-overload: a Phase I study in Japan Int J Hematol 88 73 81 10.1007/s12185-008-0115-2 1:CAS:528:DC%2BD1cXhtVOktb%2FM 18597054
3. T Suzuki M Tomonaga Y Miyazaki S Nakao K Ohyashiki I Matsumura, et al. 2008 Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes Int J Hematol 88 30 35 10.1007/s12185-008-0119-y 1:CAS:528:DC%2BD1cXhtVOktLfE 18581199
4. PD Jensen L Heickendorff B Pedersen K Bendix-Hansen FT Jensen T Christensen, et al. 1996 The effect of iron chelation on haemopoiesis in MDS patients with transfusional iron overload Br J Haematol 94 288 299 10.1046/j.1365-2141.1996.d01-1795.x 1:STN:280:DyaK28zis1agsw%3D%3D 8759889 (Pubitemid 26247987)
5. E Messa D Cilloni F Messa F Arruga A Roetto G Saglio 2008 Deferasirox treatment improved the hemoglobin level and decreased transfusion requirements in four patients with the myelodysplastic syndrome and primary myelofibrosis Acta Haematol 120 70 74 10.1159/000158631 1:CAS:528:DC%2BD1cXhsVGgs7zF 18827475
6. S Capalbo G Spinosa MG Franzese G Palumbo 2009 Early deferasirox treatment in a patient with myelodysplastic syndrome results in a long-term reduction in transfusion requirements Acta Haematol 121 19 20 10.1159/000209206 19287132
7. JL Spivak 2002 Polycythemia vera: myths, mechanisms, and management Blood 100 4272 4290 10.1182/blood-2001-12-0349 1:CAS:528:DC%2BD38XpsFCqsrY%3D 12393615 (Pubitemid 35429665)
8. F Louache U Testa P Pelicci P Thomopoulos M Titeux H Rochant 1984 Regulation of transferring receptors in human hematopoietic cell lines J Biol Chem 259 11576 11582 1:CAS:528:DyaL2cXls1yis70%3D 6088552 (Pubitemid 14010050)
9. R Tehranchi R Invernizzi A Grandien B Zhivotovsky B Fadeel AM Forsblom, et al. 2005 Aberrant mitochondrial iron distribution and maturation arrest characteriza early erythroid precursors in low-risk myelodysplastic syndromes Blood 106 247 253 10.1182/blood-2004-12-4649 1:CAS:528:DC%2BD2MXlvVWjtr4%3D 15755901 (Pubitemid 40967200)
10. Y Kohgo K Ikuta T Ohtake Y Torimoto J Kato 2008 Body iron metabolism and pathophysiology of iron overload Int J Hematol 88 7 15 10.1007/s12185-008-0120-5 1:CAS:528:DC%2BD1cXhtVOktLfJ 18594779
11. A Cortelezzi C Cattaneo S Cristiani L Duca B Sarina GL Deliliers, et al. 2000 Non-transferrin-bound iron in myelodysplastic syndromes: a marker of ineffective erythropoiesis? Hematol J 1 153 158 10.1038/sj.thj.6200028 1:STN:280:DC%2BD387oslCkuw%3D%3D 11920184
12. GJ Kontoghiorghes A May 1990 Uptake and intracellular distribution of iron from transferring and chelators in erythroid cell Biol Met 3 183 187 10.1007/BF01140577 1:CAS:528:DyaK3MXktVSitro%3D 2073459
13. G Vreugdenhil M Smeets RA Feelders HG Van Eijk 1993 Iron chelators may enhance erythropoiesis by increasing iron delivery to haematopoietic tissue and erythropoietin response in iron-loading anaemia Acta Haematol 89 57 60 10.1159/000204488 1:CAS:528:DyaK3sXmtFKqtbY%3D 8503244 (Pubitemid 23193193)