Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort

European Journal of Neurology

Volumn 17, Issue 5, 2010, Pages 740-745

  Martinelli Boneschi, F ^a   Esposito, F ^a   Scalabrini, D ^b   Fenoglio, C ^b   Rodegher, M E ^a   Brambilla, P ^a   Colombo, B ^a   Ghezzi, A ^c   Capra, R ^d   Collimedaglia, L ^e   Coniglio, G ^f   De Riz, M ^b   Serpente, M ^b   Cantoni, C ^b   Scarpini, E ^b   Martinelli, V ^a   Galimberti, D ^b   Comi, G ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c Ospedale di Gallarate   (Italy)

^d Multiple Sclerosis Centre   (Italy)

^e MAGGIORE DELLA CARITÀ HOSPITAL   (Italy)

^f SAN CARLO HOSPITAL   (Italy)

Author keywords

KIF1B; Neurodegeneration; Primary progressive multiple sclerosis; Risk factor; Single nucleotide polymorphism

Indexed keywords

KIF1B PROTEIN; KINESIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DISABILITY; DISEASE SEVERITY; FEMALE; GENE REPLICATION; GENETIC RISK; GENOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NERVE DEGENERATION; PRIORITY JOURNAL;

ADULT; COHORT STUDIES; DISEASE PROGRESSION; DNA REPLICATION TIMING; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; ITALY; KINESIN; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX;

EID: 77950913321     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02925.x     Document Type: Article

References (28)

1. Mayr WT, Pittock SJ, McClelland RL, Jorgensen NW, Noseworthy JH, Rodriguez M. Incidence and prevalence of multiple sclerosis in Olmsted County, Minnesota, 1985-2000. Neurology 2003 61 : 1373 1377. (Pubitemid 37463373)
2. Sadovnick AD, Baird PA, Ward RH. Multiple sclerosis: updated risk for relatives. Am J Med Genet 1988 29 : 533 541.
3. Montomoli C, Prokopenko I, Caria A, et al. Multiple Sclerosis recurrence risk for siblings in an isolated population of central Sardinia, Italy. Genet Epidemiol 2002 22 : 265 271. (Pubitemid 34246666)
4. Ebers GC, Bulman DE, Sadovnick AD, et al. A population-based study of multiple sclerosis in twins. N Engl J Med 1986 315 : 1638 1642. (Pubitemid 17052896)
5. Sadovnick AD, Armstrong H, Rice GP, Ebers GC, et al. A population-based study of multiple sclerosis in twins: update. Ann Neurol 1993 33 : 281 285. (Pubitemid 23081159)
6. Kinnunen E, Juntunen J. Genetic susceptibility to multiple sclerosis: a co-twin study of a nation-wide series. Arch Neurol 1988 45 : 1108 1111.
7. Compston A, Ebers G, Lassmann H, McDonald I, Matthews B, Wekerle H. McAlpine's Multiple Sclerosis, 3rd edn.
8. International Multiple Sclerosis Genetics Consortium (IMSGC). The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun 2009 10 : 11 14.
9. International Multiple Sclerosis Genetics Consortium (IMSGC). Refining genetic associations in multiple sclerosis. Lancet Neurol 2008 7 : 567 569.
10. De Jager PL, Baecher-Allan C, Maier LM, et al. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A 2009 106 : 5264 5269.
11. Hafler DA, Compston A, Sawcer S, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007 357 : 851 862. (Pubitemid 47347319)
12. De Jager PL, Jia X, Wang J, et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009 41 : 776 782.
13. Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 2008 31 : 247 269.
14. Firscher JM, Bramow S, Dal-Bianco A, et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009 132 : 1175 1189.
15. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996 46 : 907 911.
16. Leary SM, Thompson AJ. Primary progressive multiple sclerosis: current and future treatment options. CNS Drugs 2005 19 : 369 376. (Pubitemid 41124012)
17. Tallantyre EC, Bo L, Al-Rawashdeh O, et al. Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease. Brain 2009 132 : 1190 1199.
18. Aulchenko YS, Hoppenbrouwers IA, Rawagopalan SV, et al. Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nat Genet 2008 40 : 1402 1403.
19. Roxburgh RH, Seaman SR, Masterman T, et al. Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity. Neurology 2005 64 : 1144 1151. (Pubitemid 40490510)
20. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001 50 : 121 127.
21. Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald criteria". Ann Neurol 2005 58 : 840 846. (Pubitemid 41746873)
22. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983 33 : 1444 1452.
23. Fenoglio C, Galimberti D, Ban M, et al. SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis. Neurosci Lett 2006 394 : 92 96. (Pubitemid 43061466)
24. Ebers GC. Natural history of primary progressive multiple sclerosis. Mult Scler 2004 10 : S8 S15.
25. Sawcer SJ. A new era of genetics in understanding complex autoimmune disorders. Mult Scler 2009 15 : S9.
26. Stevenson VL, Miller DH, Rovaris M, et al. Primary and transitional progressive MS: a clinical and MRI cross-sectional study. Neurology 1999 52 : 839 845. (Pubitemid 29120193)
27. Lyons DA, Naylor SG, Scholze A, Talbot WS. Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. Nat Genet 2009 41 : 854 858.
28. Lao O, Lu TT, Nothnagel M, et al. Correlation between genetic and geographic structure in Europe. Curr Biol 2008 18 : 1241 1248.