Male and female rats with severe protein restriction present delayed wound healing

Applied Physiology, Nutrition and Metabolism

Volumn 34, Issue 6, 2009, Pages 1023-1031

  Otranto, Marcela ^a   Souza Netto, Isabel ^a   Águila, Márcia Barbosa ^a   Monte Alto Costa, Andréa ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Myofibroblasts; Protein; Skin; Undernutrition; Vascularization; Wound healing

Indexed keywords

ACTIN; PLASMA PROTEIN; SERUM ALBUMIN;

ANGIOGENESIS; ANIMAL; ARTICLE; BODY WEIGHT; EXTRACELLULAR MATRIX; FEMALE; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; INJURY; MALE; MAST CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN DEFICIENCY; PROTEIN RESTRICTION; RAT; SEXUAL DEVELOPMENT; SKIN; VASCULARIZATION; WISTAR RAT; WOUND HEALING;

ACTINS; ANIMALS; BLOOD PROTEINS; BODY WEIGHT; DIET, PROTEIN-RESTRICTED; EXTRACELLULAR MATRIX; FEMALE; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MAST CELLS; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN DEFICIENCY; RATS; RATS, WISTAR; SERUM ALBUMIN; SEX CHARACTERISTICS; SKIN; WOUND HEALING;

EID: 77950891849     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H09-100     Document Type: Article

References (37)

1. Black, M.M., Baqui, A.H., Zaman, K., Ake Persson, L., El Arifeen, S., Le, K., et al. 2004. Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants. Am. J. Clin. Nutr. 80(4): 903-910. PMID:15447897.
2. Boelsma, E., van de Vijver, L.P.L., Goldbohm, R.A., Klöpping-Ketelaars, I.A., Hendriks, H.F., and Roza, L. 2003. Human skin condition and its associations with nutrient concentrations in serum and diet. Am. J. Clin. Nutr. 77(2): 348-355. PMID: 12540393.
3. Brown, L.F., Yeo, K.T., Berse, B., Yeo, T.K., Senger, D.R., Dvorak, H.F., and van de Water, L. 1992. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J. Exp. Med. 176(5): 1375-1379. doi:10.1084/jem.176.5.1375. PMID: 1402682.
4. Bryzgalova, G., Lundholm, L., Portwood, N., Gustafsson, J.A., Khan, A., Efendic, S., and Dahlman-Wright, K. 2008. Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Am. J. Physiol. Endocrinol. Metab. 295(4): E904-E912. doi:10.1152/ajpendo.90248.2008. PMID:18697913.
5. Cascone, I., Giraudo, E., Caccavari, F., Napione, L., Bertotti, E., Collard, J.G., et al. 2003. Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA. J. Biol. Chem. 278(50): 50702-50713. doi:10. 1074/jbc.M307234200. PMID:12972426.
6. Cattaneo, L., De Gennaro Colonna, V., Zoli, M., Müller, E.E., and Cocchi, D. 1997. Hypothalamo-pituitary-IGF-1 axis in female rats made obese by overfeeding. Life Sci. 61(9): 881-889. doi:10.1016/S0024-3205(97)00590-0. PMID:9284081.
7. Costarelli, V., and Emery, P.W. 2009. The effect of protein malnutrition on the capacity for protein synthesis during wound healing. J. Nutr. Health Aging, 13(5): 409-412. PMID:19390746.
8. Cowan, D.T., Roberts, J.D., Fitzpatrick, J.M., While, A.E., and Baldwin, J. 2004. Nutritional status of older people in long term care settings: current status and future directions. Int. J. Nurs. Stud. 41(3): 225-237. doi:10.1016/S0020-7489(03)00131-7. PMID:14967179.
9. Fraker, P.J. 2005. Roles for cell death in zinc deficiency. J. Nutr. 135(3): 359-362. PMID:15735063.
10. Fuchs, G., Ahmed, T., Araya, M., Baker, S., Croft, N., and Weaver, L.; North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. 2004. Malnutrition: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J. Pediatr. Gastroenterol. Nutr. 39(Suppl. 2): S670-S677. doi:10.1097/00005176-200406002-00014. PMID:15184768.
11. Haydock, D.A., and Hill, G.L. 1986. Impaired wound healing in surgical patients with varying degrees of malnutrition. JPEN J. Parenter. Enteral Nutr. 10(6): 550-554. doi:10.1177/0148607186010006550. PMID:3098996.
12. Hinz, B., Dugina, V., Ballestrem, C., Wehrle-Haller, B., and Chaponnier, C. 2003. Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Mol. Biol. Cell, 14(6): 2508-2519. doi:10.1091/mbc.E02-11-0729. PMID: 12808047.
13. Keithley, J.K. 1983. Infection and the malnourished patient. Heart Lung, 12(1): 23-27. PMID:6401274.
14. Kobayashi, N., Nagai, H., Yasuda, Y., and Kanazawa, K. 2004. The early influence of albumin administration on protein metabolism and wound healing in burned rats. Wound Repair Regen. 12(1): 109-114. PMID:14974972.
15. Kurz, A., Sessler, D.I., and Lenhardt, R. 1996. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization Study of Wound Infection and Temperature Group. N. Engl. J. Med. 334(19): 1209-1215. doi:10.1056/NEJM199605093341901. PMID:8606715.
16. Lee, M.O. 1929. Determination of the surface area of the white rat with application to the expression of metabolic results. Am. J. Physiol. 89: 23-33.
17. Marín, L.A., Salido, J.A., López, A., and Silva, A. 2002. Preoperative nutritional evaluation as a prognostic tool for wound healing. Acta Orthop. Scand. 73(1): 2-5. doi:10.1080/000164702317281323. PMID:11928905.
18. McKeehan, W.L., and McKeehan, K.A. 1980. Serum factors modify the cellular requirement for Ca2+, K+, Mg2+, phosphate ions, and 2-oxocarboxylic acids for multiplication of normal human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 77(6): 3417-3421. doi:10.1073/pnas.77.6.3417. PMID:6932028.
19. McKeehan, W.L., McKeehan, K.A., and Calkins, D. 1981. Extra-cellular regulation of fibroblast multiplication. Quantitative differences in nutrient and serum factor requirements for multiplication of normal and SV40 virus-transformed human lung cells. J. Biol. Chem. 256(6): 2973-2981. PMID:6259146.
20. Mistry, D., Andrassy, R.J., Pizzini, R., and Parks, D. 1994. Quantitative analysis of collagen accumulation during protein malnutrition. J. Pediatr. Surg. 29(7): 863-865. doi:10.1016/0022-3468(94)90003-5. PMID:7931958.
21. Müller, O., and Krawinkel, M. 2005. Malnutrition and health in developing countries. CMAJ, 173(3): 279-286. PMID:16076825.
22. Nagy, J.A., and Senger, D.R. 2006. VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype. Exp. Cell Res. 312(5): 538-548. doi:10.1016/j.yexcr.2005.10.017. PMID: 16310771.
23. Oishi, Y., Fu, Z., Ohnuki, Y., Kato, H., and Noguchi, T. 2002. Effects of protein deprivation on alpha1(I) and alpha1(III) collagen and its degrading system in rat skin. Biosci. Biotechnol. Biochem. 66(1): 117-126. doi:10.1271/bbb.66.117. PMID: 11866093.
24. Okuda, S., Nakamura, T., Yamamoto, T., Ruoslahti, E., and Border, W.A. 1991. Dietary protein restriction rapidly reduces transforming growth factor beta 1 expression in experimental glomerulonephritis. Proc. Natl. Acad. Sci. U.S.A. 88(21): 9765-9769. doi:10.1073/pnas.88.21.9765. PMID:1946401.
25. Reed, M.J., Penn, P.E., Li, Y., Birnbaum, R., Vernon, R.B., Johnson, T.S., et al. 1996. Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice. Mech. Ageing Dev. 89(1): 21-43. doi:10.1016/0047-6374(96)01737-X. PMID:8819104.
26. Reeves, P.G., Nielsen, F.H., and Fahey, G.C., Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123(11): 1939-1951. PMID:8229312.
27. Roberts, P.R., Black, K.W., Santamauro, J.T., and Zaloga, G.P. 1998. Dietary peptides improve wound healing following surgery. Nutrition, 14(3): 266-269. doi:10.1016/S0899-9007(97)00468-1. PMID:9583369.
28. Schaible, U.E., and Kaufmann, S.H. 2007. Malnutrition and infection: complex mechanisms and global impacts. PLoS Med. 4(5): e115. doi:10.1371/journal.pmed.0040115. PMID:17472433.
29. Sullivan, D.H., Sun, S., and Walls, R.C. 1999. Protein-energy malnutrition among elderly hospitalized patients: a prospective study. JAMA, 281(21): 2013-2019. doi:10.1001/jama.281.21.2013. PMID:10359390.
30. Thomas, T., Burguera, B., Melton, L.J., 3rd, Atkinson, E.J., O'Fallon, W.M., Riggs, B.L., Khosla, S. 2001. Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women. Bone, 29(2): 114-120. PMID:11502471.
31. Umeno, Y., Okuda, A., and Kimura, G. 1989. Proliferative behaviour of fibroblasts in plasma-rich culture medium. J. Cell Sci. 94(Pt. 3): 567-575. PMID:2632584.
32. Veiga, M.C., Tambeli, C.H., Santoa, A.C., and José, J.L. 1992. Effect of dietary protein levels on the genesis of repair tissue in rats. Arch. Latinoam. Nutr. 42(4): 414-419. [In Portuguese.] PMID:1285260.
33. Vituri, C.L., Alvarez-Silva, M., Trentin, A.G., and Borelli, P. 2000. Alterations in proteins of bone marrow extracellular matrix in undernourished mice. Braz. J. Med. Biol. Res. 33(8): 889-895. doi:10.1590/S0100-879X2000000800004. PMID:10920430.
34. Voss, B., Rauterberg, J., and Müller, K.M. 1994. The perivascular connective matrix. Pathol. Res. Pract. 190(9-10): 969-983. PMID:7899148.
35. Waitzberg, D.L., Caiaffa, W.T., and Correia, M.I. 2001. Hospital malnutrition: the Brazilian national survey (IBRANUTRI): a study of 4000 patients. Nutrition, 17(7-8): 573-580. doi:10.1016/S0899-9007(01)00573-1. PMID:11448575.
36. Wilmore, D.W. 2001. The effect of glutamine supplementation in patients following elective surgery and accidental injury. J. Nutr. 131(Suppl. 9): 2543S-2549S, discussion 2550S-2551S. PMID:11533310.
37. Witte, M.B., and Barbul, A. 2003. Arginine physiology and its implication for wound healing. Wound Repair Regen. 11(6): 419-423. doi:10.1046/j.1524-475X.2003.11605.x. PMID:14617280.