Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk

Carcinogenesis

Volumn 31, Issue 4, 2009, Pages 634-642

  Lam, Tram Kim ^a   Rotunno, Melissa ^a   Lubin, Jay H ^a   Wacholder, Sholom ^a   Consonni, Dario ^b,c   Pesatori, Angela C ^b,c   Bertazzi, Pier Alberto ^b,c   Chanock, Stephen J ^a   Burdette, Laurie ^a   Goldstein, Alisa M ^a   Tucker, Margaret A ^a   Caporaso, Neil E ^a   Subar, Amy F ^a   Landi, Maria Teresa ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; CYTOCHROME P450; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M2; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T2; MESSENGER RNA; QUERCETIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER RISK; CIGARETTE SMOKING; CONTROLLED STUDY; DIETARY INTAKE; DNA POLYMORPHISM; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE INTERACTION; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; UPREGULATION; CASE CONTROL STUDY; FRUIT; GENETICS; LUNG; LUNG TUMOR; METABOLISM; MIDDLE AGED; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; VEGETABLE;

AGED; CASE-CONTROL STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; FRUIT; GLUTATHIONE TRANSFERASE; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; QUERCETIN; RISK FACTORS; VEGETABLES;

EID: 77950884036     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp334     Document Type: Article

References (52)

1. Riboli,E. et al. (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am. J. Clin. Nutr., 78, 559S-569S.
2. World Cancer Research Fund/American Institute for Cancer Research. (2007) Food, Nutrition, Physical Activity, and the Prevention of cancer: a Global Perspective. AICR, Washington, DC.
3. Hecht,S.S. (2000) Inhibition of carcinogenesis by isothiocyanates. Drug Metab. Rev., 32, 395-411.
4. Reszka,E. et al. (2006) Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility. Br. J. Nutr., 96, 609-619.
5. Lampe,J.W. (2007) Diet, genetic polymorphisms, detoxification, and health risks. Altern. Ther. Health Med., 13, S108-S111.
6. Lam,T.K. et al. (2009) Cruciferous vegetable consumption and lung cancer risk: a systematic review. Cancer Epidemiol. Biomarkers Prev., 18, 184-195.
7. Lamson,D.W. et al. (2000) Antioxidants and cancer, part 3: quercetin. Altern. Med. Rev., 5, 196-208.
8. Murakami,A. et al. (2008) Multitargeted cancer prevention by quercetin. Cancer Lett., 269, 315-325.
9. Tan,X.L. et al. (2009) Dietary chemoprevention strategies for induction of phase II xenobiotic-metabolizing enzymes in lung carcinogenesis: a review. Lung Cancer, 65, 129-137.
10. Deschner,E.E. et al. (1991) Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis, 12, 1193-1196.
11. Verma,A.K. et al. (1988) Inhibition of 7,12-dimethylbenz(a)anthracene-and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Res., 48, 5754-5758.
12. Hung,H. (2007) Dietary quercetin inhibits proliferation of lung carcinoma cells. Forum Nutr., 60, 146-157.
13. de Boer,V.C. et al. (2005) Tissue distribution of quercetin in rats and pigs. J. Nutr., 135, 1718-1725.
14. Hirvonen,T. et al. (2001) Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control, 12, 789-796.
15. Knekt,P. et al. (2002) Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr., 76, 560-568.
16. Stefani,E.D. et al. (1999) Dietary antioxidants and lung cancer risk: a case-control study in Uruguay. Nutr. Cancer, 34, 100-110.
17. Cui,Y. et al. (2008) Dietary flavonoid intake and lung cancer-a population-based case-control study. Cancer, 112, 2241-2248.
18. Garcia-Closas,R. et al. (1998) Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain. Nutr. Cancer, 32, 154-158.
19. Le Marchand,L. et al. (2000) Intake of flavonoids and lung cancer. J. Natl Cancer Inst., 92, 154-160.
20. Kang,Z.C. et al. (1999) Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression. Nutr. Cancer, 35, 175-179.
21. Schwarz,D. et al. (2005) CYP1A1 genotype-selective inhibition of benzo [a]pyrene activation by quercetin. Eur. J. Cancer, 41, 151-158.
22. Lodovici,M. et al. (2004) Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. Cancer Epidemiol. Bio-markers Prev., 13, 1342-1348.
23. Husgafvel-Pursiainen,K. (2004) Genotoxicity of environmental tobacco smoke: a review. Mutat. Res., 567, 427-445.
24. Agundez,J.A. (2004) Cytochrome P450 gene polymorphism and cancer. Curr. Drug Metab., 5, 211-224.
25. Ye,Z. et al. (2006) Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies. PLoS Med., 3, e91.
26. Moon,Y.J. et al. (2006) Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol. In Vitro, 20, 187-210.
27. Tang,D. et al. (2001) Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study. Cancer Res., 61, 6708-6712.
28. Landi,M.T. et al. (2008) Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer. BMC Public Health, 8, 203.
29. Nutrient Data Laboratory. (2003) USDA Database for the Flavonoid Content of Selected Foods. United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Nutrient Data Laboratory, Beltsville, MD.
30. Rotunno,M. et al. (2009) Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. PLoS ONE, 4, e5652.
31. Landi,M.T. et al. (2008) Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. PLoS ONE, 3, e1651.
32. Hochreiter,S. et al. (2006) A new summarization method for Affymetrix probe level data. Bioinformatics, 22, 943-9.
33. Rothman,K. (2002) Epidemiology. An Introduction. Oxford University Press, New York.
34. Andersson,T. et al. (2005) Calculating measures of biological interaction. Eur. J. Epidemiol., 20, 575-579.
35. StataCorp. (2005) Stata Statistical Software: Release 9. StataCorp LP, College Station, TX.
36. Team,R.D.C. (2008) R: A Language and Environment for Statistical Computing R Foundation for Statistical Computing. R Development Core Team, Vienna, Austria.
37. Wright,M.E. et al. (2008) Intakes of fruit, vegetables, and specific botanical groups in relation to lung cancer risk in the NIH-AARP Diet and Health Study. Am. J. Epidemiol., 168, 1024-1034.
38. Yang,J.H. et al. (2006) Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab. Dispos., 34, 296-304.
39. Obermeier,M.T. et al. (1995) Effects of bioflavonoids on hepatic P450 activities. Xenobiotica, 25, 575-584.
40. van Zanden,J.J. et al. (2003) Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin. Chem. Biol. Interact., 145, 139-148.
41. Guengerich,F.P. et al. (1991) Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem. Res. Toxicol., 4, 391-407.
42. Valerio,L.G.Jr et al. (2001) Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol. Lett., 119, 49-57.
43. Seow,A. et al. (2005) Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: an epidemiological perspective. Mutat. Res., 592, 58-67.
44. Perneger,T.V. (1998) What's wrong with Bonferroni adjustments. BMJ, 316, 1236-1238.
45. Hertog,M.G. et al. (1996) Potential health effects of the dietary flavonol quercetin. Eur. J. Clin. Nutr., 50, 63-71.
46. Kamaraj,S. et al. (2007) The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol. Pharm. Bull., 30, 2268-2273.
47. Jeong,J.H. et al. (2008) Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J. Cell. Biochem., 106, 73-82.
48. Psahoulia,F.H. et al. (2007) Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. Mol. Cancer Ther., 6, 2591-2599.
49. Kipnis,V. et al. (2001) Empirical evidence of correlated biases in dietary assessment instruments and its implications. Am. J. Epidemiol., 153, 394-403.
50. Kipnis,V. et al. (2003) Structure of dietary measurement error: results of the OPEN biomarker study. Am. J. Epidemiol., 158, 14-21; (discussion 22-26).
51. Jakes,R.W. et al. (2004) Adjusting for energy intake-what measure to use in nutritional epidemiological studies? Int. J. Epidemiol., 33, 1382-1386.
52. Alberg,A. (2002) The influence of cigarette smoking on circulating concentrations of antioxidant micronutrients. Toxicology, 180, 121-137.