Effects of introducing a single charged residue into the phenylalanine clamp of multimeric anthrax protective antigen

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 8130-8137

  Janowiak, Blythe E ^a   Fischer, Audrey ^a   Collier, R John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC AMINO ACIDS; ACIDIC RESIDUES; ANTHRAX TOXINS; BROWNIAN RATCHET; CHARGED RESIDUES; CLOSE PROXIMITY; CYTOSOLIC COMPARTMENTS; ELECTROSTATIC INTERACTIONS; ENDOSOMAL MEMBRANE; MAMMALIAN CELLS; MULTIMERIC; N-TERMINALS; PHOSPHOLIPID BILAYER; POSITIVELY CHARGED; PROTECTIVE ANTIGENS; SIDE CHAINS; TRANSLOCATION PROCESS;

AMINO ACIDS; BROWNIAN MOVEMENT; MAMMALS; ORGANIC ACIDS; PHOSPHOLIPIDS;

ANTIGENS;

AMINO ACID; ANTHRAX TOXIN; BACTERIAL ANTIGEN; GLUTAMIC ACID; HISTIDINE; PHENYLALANINE; PROTECTIVE ANTIGEN; PROTEIN; UNCLASSIFIED DRUG; BACTERIAL TOXIN; GLUTAMINE; HISTAMINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CHANNEL GATING; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENDOSOME; INTRACELLULAR TRANSPORT; MAMMAL CELL; MEMBRANE STRUCTURE; NONHUMAN; PHENYLALANINE CLAMP; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; STATIC ELECTRICITY; SURFACE CHARGE; AMINO ACID SUBSTITUTION; CELL MEMBRANE POTENTIAL; CHEMISTRY; ELECTRON SPIN RESONANCE; GENETICS; LIPID BILAYER; METABOLISM; MUTAGENESIS; PH; PROTEIN QUATERNARY STRUCTURE; PROTEIN TRANSPORT;

MAMMALIA;

AMINO ACID SUBSTITUTION; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENDOSOMES; GLUTAMINE; HISTAMINE; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; LIPID BILAYERS; MEMBRANE POTENTIALS; MUTAGENESIS; PHENYLALANINE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT;

EID: 77950880249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.093195     Document Type: Article

References (39)

1. Young, J. A., and Collier, R. J. (2007) Annu. Rev. Biochem. 76, 243-265
2. Alfano, R. W., Leppla, S. H., Liu, S., Bugge, T. H., Herlyn, M., Smalley, K. S., Bromberg-White, J. L., Duesbery, N. S., and Frankel, A. E. (2008) Mol. Cancer Ther. 7, 1218-1226
3. Chen, D., Misra, M., Sower, L., Peterson, J. W., Kellogg, G. E., and Schein, C. H. (2008) Bioorg. Med. Chem. 16, 7225-7233
4. Finkelstein, A. (1994) Toxicology 87, 29-41
5. Ezzell, J. W., Jr., and Abshire, T. G. (1992) J. Gen. Microbiol. 138, 543-549
6. Goldman, D. L., Zeng, W., Rivera, J., Nakouzzi, A., and Casadevall, A. (2008) Clin. Vaccine Immunol. 15, 970-973
7. Klimpel, K. R., Molloy, S. S., Thomas, G., and Leppla, S. H. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 10277-10281
8. Molloy, S. S., Bresnahan, P. A., Leppla, S. H., Klimpel, K. R., and Thomas, G. (1992) J. Biol. Chem. 267, 16396-16402
9. Kintzer, A. F., Thoren, K. L., Sterling, H. J., Dong, K. C., Feld, G. K., Tang, II, Zhang, T. T., Williams, E. R., Berger, J. M., and Krantz, B. A. (2009) J. Mol. Biol. 392, 614-629
10. Wigelsworth, D. J., Krantz, B. A., Christensen, K. A., Lacy, D. B., Juris, S. J., and Collier, R. J. (2004) J. Biol. Chem. 279, 23349-23356
11. Gordon, V. M., Leppla, S. H., and Hewlett, E. L. (1988) Infect. Immun. 56, 1066-1069
12. Singh, Y., Klimpel, K. R., Goel, S., Swain, P. K., and Leppla, S. H. (1999) Infect. Immun. 67, 1853-1859
13. Singh, Y., Leppla, S. H., Bhatnagar, R., and Friedlander, A. M. (1989) J. Biol. Chem. 264, 11099-11102
14. Miller, C. J., Elliott, J. L., and Collier, R. J. (1999) Biochemistry 38, 10432-10441
15. Nassi, S., Collier, R. J., and Finkelstein, A. (2002) Biochemistry 41, 1445-1450
16. Krantz, B. A., Trivedi, A. D., Cunningham, K., Christensen, K. A., and Collier, R. J. (2004) J. Mol. Biol. 344, 739-756
17. Thoren, K. L., Worden, E. J., Yassif, J. M., and Krantz, B. A. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 21555-21560
18. Wesche, J., Elliott, J. L., Falnes, P. O., Olsnes, S., and Collier, R. J. (1998) Biochemistry 37, 15737-15746
19. Pannifer, A. D., Wong, T. Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Bienkowska, J., Lacy, D. B., Collier, R. J., Park, S., Leppla, S. H., Hanna, P., and Liddington, R. C. (2001) Nature 414, 229-233
20. Zhang, S., Finkelstein, A., and Collier, R. J. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 16756-16761
21. Krantz, B. A., Finkelstein, A., and Collier, R. J. (2006) J. Mol. Biol. 355, 968-979
22. Zhang, S., Udho, E., Wu, Z., Collier, R. J., and Finkelstein, A. (2004) Biophys. J. 87, 3842-3849
23. Krantz, B. A., Melnyk, R. A., Zhang, S., Juris, S. J., Lacy, D. B., Wu, Z., Finkelstein, A., and Collier, R. J. (2005) Science 309, 777-781
24. Sun, J., Lang, A. E., Aktories, K., and Collier, R. J. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 4346-4351
25. Janowiak, B. E., Finkelstein, A., and Collier, R. J. (2009) Protein Sci. 18, 348-358
26. Leppla, S. H. (2001) Nat. Med. 7, 659-660
27. Mourez, M., Yan, M., Lacy, D. B., Dillon, L., Bentsen, L., Marpoe, A., Maurin, C., Hotze, E., Wigelsworth, D., Pimental, R. A., Ballard, J. D., Collier, R. J., and Tweten, R. K. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 13803-13808
28. Sellman, B. R., Mourez, M., and Collier, R. J. (2001) Science 292, 695-697
29. Sellman, B. R., Nassi, S., and Collier, R. J. (2001) J. Biol. Chem. 276, 8371-8376
30. Singh, Y., Khanna, H., Chopra, A. P., and Mehra, V. (2001) J. Biol. Chem. 276, 22090-22094
31. Milne, J. C., Blanke, S. R., Hanna, P. C., and Collier, R. J. (1995) Mol. Microbiol. 15, 661-666
32. Bernard, A., and Payton, M. (1995) in Current Protocols in Protein Science (Coligan, J. E., Dunn, B. M., Speicher, D. W., Wingfield, P. T., and Ploegh, H. L., eds) pp. 5.3.1-5.3.18, John Wiley and Sons, New York
33. Mueller, P., and Rudin, D. O. (1963) J. Theor. Biol. 4, 268-280
34. Robinson, R. A., and Stokes, R. H. (1965) Electrolyte Solutions, 2nd Ed., Butterworths, London
35. Hille, B. (2001) Ion Channels of Excitable Membranes, Third Ed., Sinauer Associates, Sunderland, MA
36. Basilio, D., Juris, S. J., Collier, R. J., and Finkelstein, A. (2009) J. Gen. Physiol. 133, 307-314
37. Melnyk, R. A., and Collier, R. J. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 9802-9807
38. Lacy, D. B., Wigelsworth, D. J., Melnyk, R. A., Harrison, S. C., and Collier, R. J. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 13147-13151
39. Katayama, H., Janowiak, B. E., Brzozowski, M., Juryck, J., Falke, S., Gogol, E. P., Collier, R. J., and Fisher, M. T. (2008) Nat. Struct. Mol. Biol. 15, 754-760