Leech therapy in cutaneous surgery and disease

Journal of Drugs in Dermatology

Volumn 9, Issue 3, 2010, Pages 252-257

  Mamelak, Adam J ^a   Jackson, Adrianna ^b   Nizamani, Rabia ^c   Arnon, Ofer ^d   Liegeois, Nanette J ^b   Redett, Richard J ^e   Byrne, Patrick J ^e  

^a HOUSTON METHODIST HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFALEXIN; ENOXAPARIN; FRESH FROZEN PLASMA; GATIFLOXACIN; HEPARIN; OXYCODONE;

ABDOMINAL DISCOMFORT; ADULT; AEROMONAS; AEROMONAS HYDROPHILA; ANTEROLATERAL THIGH FLAP; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ANTICOAGULATION; ARTERY ANASTOMOSIS; ARTICLE; BACTERIAL INFECTION; BASAL CELL CARCINOMA; BLOOD TRANSFUSION; BREAST CANCER; BREAST RECONSTRUCTION; CASE REPORT; CHILD; CHRONIC DISEASE; CLINICAL ASSESSMENT; COLITIS; COMPUTER ASSISTED TOMOGRAPHY; DEBRIDEMENT; DISSEMINATED INTRAVASCULAR CLOTTING; DOPPLER ECHOGRAPHY; EAR CARTILAGE; ERYTHEMA; ERYTHROCYTE CONCENTRATE; EXCISION; FACE SWELLING; FEMALE; FEVER; FIBULAR FREE FLAP; FOOT; FOREHEAD FLAP; FREE TISSUE GRAFT; FULMINATING PURPURA; GASTROINTESTINAL MOTILITY DISORDER; GASTROINTESTINAL SURGERY; GASTROSCHISIS; HEMATOCRIT; HEMATURIA; HEMOSTASIS; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; IMPLANT; INFECTION RISK; INTENSIVE CARE UNIT; LEECH SALIVA; LEECHING; MALABSORPTION; MALE; MASTECTOMY; MOH MICROGRAPHIC SURGERY; MOUTH CARCINOMA; MYOCUTANEOUS FLAP; NAUSEA AND VOMITING; NEUTROPHIL; NOSE CARCINOMA; ORAL SURGERY; PAIN; PAN COLITIS; PENIS; PRESCHOOL CHILD; RECURRENT CANCER; SALIVA; SKIN BIOPSY; SKIN DISEASE; SKIN FLAP SURVIVAL; SKIN NECROSIS; SKIN SURGERY; SQUAMOUS CELL CARCINOMA; STOMA; SUPERIOR GLUTEAL ARTERY PERFORATOR FREE FLAP; SURGERY; SWELLING; TREATMENT OUTCOME; VENOUS CONGESTION; WEIGHT REDUCTION; ANIMAL; CHEMOSURGERY; MIDDLE AGED; PLASTIC SURGERY;

ANIMALS; CHILD, PRESCHOOL; FEMALE; HUMANS; LEECHING; MALE; MIDDLE AGED; MOHS SURGERY; PURPURA FULMINANS; SKIN DISEASES; SURGICAL FLAPS;

EID: 77950874795     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Whitaker IS, Rao J, Izadi D, Butler PE. Historical Article: Hirudo medicinalis: Ancient origins of, and trends in the use of medicinal leeches throughout history. Br J Oral Maxillofac Surg. 2004;42(2):133-137. (Pubitemid 38401331)
2. Adams SL. The medicinal leech: A page from the annelids of internal medicine. Ann Int Med. 1988;109(5):399-405.
3. Rao J, Whitaker IS. Use of Hirudo medicinalis by maxillofacial surgical units in the United Kingdom: Current views and practice. Br J Oral Maxilofac Surg. 2003;41(1):54-55. (Pubitemid 36285116)
4. Mory RN, Mindell D, Bloom DA. The leech and the physician: Biology, etymology, and medical practice with Hirudinea medicinalis. World J Surg. 2000;24(7):878-883. (Pubitemid 30437489)
5. Ardehali B, Hand K, Nduka C, et al. Delayed leech-borne infection with Aeromonas hydrophilia in escharotic flap wound. J Plast Reconstr Aesthet Surg. 2006;59(1):94-95.
6. Whitaker IS, Cheung CK, Chahal CA, et al. By what mechanism do leeches help to salvage ischaemic tissues? A review. Br J Plast Surg. 2005;43(2):155-160. (Pubitemid 40309856)
7. Eldor A, Orevi M, Rigibi M. The role of the leech in medical therapeutics. Blood Rev. 1996;10(4):201-209. (Pubitemid 27042821)
8. Haycraft JB. On the action of secretion obtained from the medicinal leech on coagulation of the blood. Proc R Soc Lond. 1884;36:478.
9. Markwardt F. Untersuchungen über Hirudin. Naturwissenschaften. 1955;52:537.
10. Fields WS. The history of leeching and hirudin. Haemostasis. 1991;21:3-10.
11. Harvey RP, Degryse E, Stefani L, et al. Cloning and expression of cDNA coding for the anticoagulant hirudin from the blood-sucking leech Hirudo medicinalis. Proc Natl Acad Sci USA. 1986;83(4):1084-88. (Pubitemid 16086416)
12. Bergmann C, Dodt J, Kohler S, et al. Chemical synthesis and expression of gene coding for hirudin, the thrombin-specific inhibitor from the leech Hirudo medicinalis. Biol Chem Hoppe-Seyler. 1986;367(8):731-740.
13. Dodt J, Shmitz T, Schafer T, Bergmann C. Expression, secretion and processing of hirudin in E. coli using the alkaline phosphatase signal sequence. FEBS Lett. 1986;202(2):373-377. (Pubitemid 16003740)
14. Baskova IP, Nikovonv GI. Destabilase, the novel ε-(γGlu)-Lys isopeptidase with thrombolytic activity. Blood Coag Fibrinolysis. 1992(1);2:167-172.
15. Zavalova LL, Kuzina EV, Levina LB, Baskova IP. Monomerization of fraction DD by destabilase from the medicinal leech does not alter the N-terminal sequence of the γ-chain. Thromb Res. 1994;71:241-244. (Pubitemid 23217692)
16. Rigbi M, Orevi M, Eldor A. Platelet aggregation and coagulation inhibitors in leech saliva and their roles in leech therapy. Semin Thromb Hemost. 1996;22(3):273-278. (Pubitemid 26249134)
17. Kornowski R, Eldor A, Werber M, et al. Enhancement of recombinant tissue-type plasminogen activator thrombolysis with a selective factor Xa inhibitor derived from the leech Hirudo medicinalis: Comparison with heparin and hirudin in a rabbit thrombosis model. Coron Artery Dis. 1996;7(12):903-909.
18. Baskova IP, Khalil S, Nartikova VF, Pashkina TS. Inhibition of plasma kallikrein, kininase and kinin-like activities from preparations of medicinal leeches. Thromb Res. 1992; 67:3721-3730.
19. Orevi M, Rigbi M, Hy-Am E, et al. A potent inhibitor of platelet activating factor from the saliva of the leech Hirudo medicinalis. Prostaglandins. 1992;43:483-495.
20. Munro R, Jones CP, Sawyer RT. Calin-a platelet adhesion inhibitor from the saliva of the medicinal leech. Blood Coagul Fibrinolysis. 1991;2:179-184.
21. Deckmyn H, Stassen JM, Vreys I, et al. Calin from Hirudo medicinalis, an inhibitor of platelet adhesion to collagen, prevents platelet-rich thrombosis in hamsters. Blood. 1995;85:712-719.
22. Harsfalvi J, Stassen JM, Hoylaerts MF et al. Calin from Hirudo medicinalis, an inhibitor of von Willebrand factor to binding to collagen under static and flow conditions. Blood. 1995;85:705-711.
23. Conforti ML, Connor NP, Heisey DM, Hartig GK. Evaluation of performance characteristics of the medicinal leech (Hirudo medicinalis) for the treatment of venous congestion. Plast Reconstr Surg. 2002;109(1):228-235. (Pubitemid 34056681)
24. Kraemer BA, Korber KE, Aquino TI, Engleman A. Use of leeches in plastic and reconstructive surgery: A review. J Reconstr Microsurg. 1988;4:381.
25. Batchelor AGG, Davison P, Sully L. The salvage of congested skin flaps by the application of leeches. Br J Plast Surg. 1984;34:358-360. (Pubitemid 15164690)
26. Rao P, Bailie FB, Bailey BN. Leechmania in microsurgery. Practitioner. 1985;229:901.
27. Cho BH, Ahn HB. Microsurgical replantation of a partial ear, with leech therapy. Ann Plast Surg. 1999;43:427-429. (Pubitemid 29463784)
28. Mortenson BW, Dawson KH, Murakami C. Medicinal leeches used to salvage a traumatic nasal flap. Br J Oral Maxillofac Surg. 1998;36:462-464. (Pubitemid 28564314)
29. Soucacos, PN, Beris, AE, Malizos, KN, et al. The use of medicinal leeches, Hirudo medicinalis, to restore venous circulation in trauma and reconstructive microsurgery. Int Angiol. 1994;13:251.
30. Haycox CL, Odland PB, Coltrera MD, et al. Indications and complications of medicinal leech therapy. J Am Acad Dermatol. 1995;33:1053-1055.
31. Byrne PJ, Bernstein, PE. The use of medicinal leeches to treat macroglossia secondary to blunt trauma. Otolaryngol Head Neck Surg. 2001;125:649-650. (Pubitemid 33664944)
32. De Chalain T, Cohen SR, Burstein FD. Successful use of leech therapy in purpura fulminans. Ann Plast Surg. 1995;35:300-306.
33. Henderson HP, Matti B, Laing AG, et al. Avulsion of the scalp treated by microvascular repair. The use of leeches for post operative decongestion. Br J Plast Surg. 1983;36:235-239. (Pubitemid 13097719)
34. Mutimer KL, Banis JC, Upton J. Microsurgical reattachment of totally amputated ears. Plast Reconstr Surg. 1987;79:535-540. (Pubitemid 17075956)
35. Brody GA, Mahoney WJ, Hentz VR. Digit replantation applying the leech Hirudo medicinalis. Clin Orthop. 1989; 133:245-249.
36. Lineaweaver WC, Hill MK, Buncke GM, et al. Aeromonas hydrophila infections following use of medicinal leeches in replantation and flap surgery. Ann Plast Surg. 1992;29:238-244.
37. Smolle J, Cerroni L, Kerl H. Multiple pseudolymphomas caused by Hirudo medicinalis therapy. J Am Acad Dermatol. 2000;43:867-869.
38. Michalsen A, Klotz S, Ludtke R, et al. Effectiveness of leech therapy in osteoarthritis of the knee: A randomized, controlled trial. Ann Intern Med. 2003;139:724-730
39. Conforti ML, Connor NP, Heisey DM, et al. Development of a mechanical device to replace medicinal leech (Hirudo medicinalis) for treatment of venous congestion. Rehabil Res Dev. 2002;39:497-504.