Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: Critical role for glutamate receptors

Neuroscience

Volumn 167, Issue 2, 2010, Pages 205-215

  Ramiro Fuentes, S ^a   Ortiz, O ^b,c   Moratalla, R ^b,c   Fernandez Espejo, E ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b INSTITUTO CAJAL   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Cannabinoid; CB1 receptor; Glutamate; Nucleus accumbens; Reward; Rimonabant

Indexed keywords

AMPA RECEPTOR; CANNABINOID 1 RECEPTOR; COCAINE; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RIMONABANT;

ANALYSIS OF VARIANCE; ANIMAL TISSUE; ARTICLE; AVERSION; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTERNALIZATION; LENTIVIRINAE; NEUROTRANSMISSION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ANIMALS; AVOIDANCE LEARNING; COCAINE; CONDITIONING, CLASSICAL; DRUG INVERSE AGONISM; GENE SILENCING; LENTIVIRUS; LIGANDS; NUCLEUS ACCUMBENS; PIPERIDINES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; RECEPTORS, GLUTAMATE; REWARD;

EID: 77950863284     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.02.019     Document Type: Article

References (50)

1. Bahi A., Boyer F., Gumy C., Kafri T., Dreyer J.L. In vivo gene delivery of urokinase-type plasminogen activator with regulatable lentivirus induces behavioural changes in chronic cocaine administration. Eur J Neurosci 2004, 20(12):3473-3488.
2. -induced behavioural changes during chronic cocaine administration: in vivo gene delivery with regulatable lentivirus. Eur J Neurosci 2004, 19(6):1621-1633.
3. Baptista M.A., Martin-Fardon R., Weiss F. Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. J Neurosci 2004, 24:4723-4727.
4. Caillé S., Alvarez-Jaimes L., Polis I., Stouffer D.G., Parsons L.H. Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. J Neurosci 2007, 27(14):3695-3702.
5. Caillé S., Fernandez Espejo E., Reneric J.P., Cador M., Koob G.F., Stinus L. Total neurochemical lesion of noradrenergic neurons of the locus coeruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal. J Pharmacol Exp Ther 1999, 290:881-892.
6. Caillé S., Parsons L.H. Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway. Neuropsychopharmacology 2006, 31(4):804-813.
7. Carriba P., Ortiz O., Patkar K., Justinova Z., Stroik J., Themann A., Müller C., Woods A.S., Hope B.T., Ciruela F., Casadó V., Canela E.I., Lluis C., Goldberg S.R., Moratalla R., Franco R., Ferré S. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology 2007, 32(11):2249-2259.
8. Cervo L., Samanin R. Effects of dopaminergic and glutamatergic receptor antagonists on the acquisition and expression of cocaine conditioning place preference. Brain Res 1995, 673(2):242-250.
9. 1) receptors in the establishment of place conditioning in rats. Psychopharmacology (Berl) 1998, 135:324-332.
10. Cheer J.F., Wassum K.M., Sombers L.A., Heien M.L., Ariansen J.L., Aragona B.J., Phillips P.E., Wightman R.M. Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. J Neurosci 2007, 27(4):791-795.
11. Cornish J.L., Duffy P., Kalivas P.W. A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience 1999, 93:1359-1367.
12. Corbillé A.G., Valjent E., Marsicano G., Ledent C., Lutz B., Hervé D., Girault J.A. Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants. J Neurosci 2007, 27:6937-6947.
13. 1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats. Psychopharmacology 2001, 157:254-259.
14. De Vries T.J., Shaham Y., Homberg J.R., Crombag H., Schuurman K., Dieben J., Vanderschuren L.J., Schoffelmeer A.N. A cannabinoid mechanism in relapse to cocaine seeking. Nat Med 2001, 7:1151-1154.
15. De Vries T.J., Schoffelmeer A.N. Cannabinoid CB1 receptors control conditioned drug seeking. Trends Pharmacol Sci 2005, 26:420-426.
16. Di Chiara G. A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use. J Psychopharmacol 1998, 12:54-67.
17. El Banoua F., Caraballo I., Flores J.A., Galan-Rodriguez B., Fernandez-Espejo E. Effects on turning of microinjections into basal ganglia of D1 and D2 dopamine receptors agonists, and the cannabinoid CB1 antagonist SR 141716A in a rat Parkinson's model. Neurobiol Dis 2004, 16:377-385.
18. Fattore L., Spano S., Cossu G., Deiana S., Fadda P., Fratta W. Cannabinoid CB(1) antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats. Neuropharmacology 2005, 48(8):1097-1104.
19. Filip M., Golda A., Zaniewska M., McCreary A.C., Nowak E., Kolasiewicz W., Przegaliński E. Involvement of cannabinoid CB1 receptors in drug addiction: effects of rimonabant on behavioral responses induced by cocaine. Pharmacol Rep 2006, 58:806-819.
20. Flores J.A., Galan-Rodriguez B., Ramiro S., Fernandez-Espejo E. Role for dopamine neurons of the rostral linear nucleus and periaqueductal grey in the rewarding and sensitizing properties of heroin. Neuropsychopharmacology 2006, 31:1475-1488.
21. Gerdeman G.L., Partridge J.G., Lupica C.R., Lovinger D.M. It could be habit forming: drugs of abuse and striatal synaptic plasticity. Trends Neurosci 2003, 26:184-192.
22. Gerdeman G.L., Schechter J.B., French E.D. Context-specific reversal of cocaine sensitization by the CB(1) cannabinoid receptor antagonist rimonabant. Neuropsychopharmacology 2008, 33(11):2747-2759.
23. Ghasemzadeh M.B., Vasudevan P., Mueller C., Seubert C., Mantsch J.R. Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration. Neurosci Lett 2009, 452(2):167-171.
24. Kaddis F.G., Uretsky N.J., Wallace L.J. DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference. Brain Res 1995, 697:76-82.
25. Koob G.F., Vaccarino F.J., Amalric M., Bloom F.E. Neurochemical substrates for opiate reinforcement. NIDA Res Monogr 1986, 71:146-164.
26. Lesscher H.M.B., Hoogveld E., Burbach P.H., van Ree J.M., Gerrits M.A. Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization. Eur Neuropsychopharmacol 2005, 15:31-37.
27. Maldonado R., Rodriguez de Fonseca F. Cannabinoid addiction: behavioral models and neural correlates. J Neurosci 2002, 22:3326-3331.
28. Martin M., Ledent C., Parmentier M., Maldonado R., Valverde O. Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice. Eur J Neurosci 2000, 12(11):4038-4046.
29. Martin M., Chen B.T., Hopf F.W., Bowers M.S., Bonci A. Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nat Neurosci 2006, 9:868-869.
30. Martín A.B., Fernandez-Espejo E., Ferrer B., Gorriti M.A., Bilbao A., Navarro M., Rodriguez de Fonseca F., Moratalla R. Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors. Neuropsychopharmacology 2008, 33(7):1667-1679.
31. McClung C.A., Nestler E.J. Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 2008, 33:3-17.
32. Mogenson G.J., Jones D.L., Yim C.Y. From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 1980, 14:69-97.
33. Nestler E.J. Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2001, 2:119-128.
34. Orio L., Edwards S., George O., Parsons L.J., Koob G.F. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. J Neurosci 2009, 29:4846-4857.
35. Park W.K., Bari A.A., Jey A.R., Anderson S.M., Spealman R.D., Rowlett J.K., Pierce R.C. Cocaine administered into the medial prefrontal cortex reinstates cocaine seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. J Neurosci 2002, 22:2916-2925.
36. Paxinos G., Watson C. The Rat brain in stereotaxic coordinates 2005, Elsevier, Amsterdam.
37. Pertwee R.G. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 1997, 74:129-180.
38. Pertwee R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 1999, 6:635-664.
39. Peters J., Kalivas P.W. The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats. Psychopharmacology (Berl) 2006, 186(2):143-149.
40. 1) and μ-opioid receptors in rat nucleus accumbens. Neuroscience 2004, 127:101-112.
41. Robbe D., Kopf M., Remaury A., Bockaert J., Manzoni O.J. Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens. Proc Natl Acad Sci U S A 2002, 99:8384-8388.
42. Robinson T.E., Berridge K.C. The neural basis of drug craving: an incentive sensitization theory of addiction. Brain Res Rev 1993, 18:247-291.
43. Sari Y., Smith K.D., Ali P.K., Rebec G.V. Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. J Neurosci 2009, 29(29):9239-9243.
44. Soria G., Mendizabal V., Touriño C., Robledo P., Ledent C., Parmetier M., Maldonado R., Valverde O. Lack of CB1 cannabinoid receptor impairs cocaine self-administration. Neuropsychopharmacology 2005, 30:1670-1680.
45. Vlachou S., Nomikos G.G., Panagis G. WIN55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation. Behav Brain Res 2003, 141:215-222.
46. Vlachou S., Stamatopoulos F., Nomikos G.G., Panagis G. Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine. Int J Neuropsychopharmacol 2008, 11:905-923.
47. Ward S.J., Rosenberg M., Dykstra L.A., Walker E.A. The CB1 antagonist rimonabant (SR141716) blocks cue-induced reinstatement of cocaine seeking and other context and extinction phenomena. Drug Alcohol Depend 2009, 105(3):248-255.
48. Wiskerke J., Pattij T., Schoffelmeer A.N., De Vries T.J. The role of CB1 receptors in psychostimulant addiction. Addict Biol 2008, 13:225-238.
49. Xi Z.-X., Gilbert J.G., Peng X.-Q., Pak A.C., Li X., Gardner E.L. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. J Neurosci 2006, 26:8531-8536.
50. Xi Z.-X., Spiller K., Pak A.C., Gilbert J., Dillon C., Li X., Peng X.Q., Gardner E.L. Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology 2008, 33(7):1735-1745.