Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs

Anesthesiology

Volumn 112, Issue 4, 2010, Pages 892-899

  Sunaga, Hiroshi ^a   Zhang, Yi ^b   Savarese, John J ^a   Emala, Charles W ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ATROPINE; CISATRACURIUM; CW 002; GANTACURIUM; MUSCARINIC RECEPTOR; NEUROMUSCULAR BLOCKING AGENT; RAPACURONIUM BROMIDE; UNCLASSIFIED DRUG; URETHAN;

AIRWAY; AIRWAY PRESSURE; ANIMAL EXPERIMENT; ARTICLE; BRONCHOSPASM; DRUG EFFECT; GUINEA PIG; HEART RATE; LUNG PRESSURE; MALE; NEUROMUSCULAR BLOCKING; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SMOOTH MUSCLE CONTRACTION; VAGUS NERVE;

EID: 77950862818     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181d32016     Document Type: Article

References (24)

1. Moss J, Rosow CE: Histamine release by narcotics and muscle relaxants in humans. ANESTHESIOLOGY 1983; 59:330-339 (Pubitemid 13012523)
2. North FC, Kettelkamp N, Hirshman CA: Comparison of cutaneous and in vitro histamine release by muscle relaxants. ANESTHESIOLOGY 1987; 66:543-546 (Pubitemid 17051509)
3. Okanlami OA, Fryer AD, Hirshman CA: Interaction of nondepolarizing muscle relaxants with m2 and m3 muscarinic receptors in guinea pig lung and heart. ANESTHESIOLOGY 1996; 84:155-161
4. Jooste EH, Sharma A, Zhang Y, Emala CW: Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor. ANESTHESIOLOGY 2005; 103:1195-1203 (Pubitemid 41692503)
5. Jooste E, Zhang Y, Emala CW: Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways. ANESTHESIOLOGY 2007; 106:763-772 (Pubitemid 46555620)
6. Jooste E, Klafter F, Hirshman CA, Emala CW: A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism. ANESTHESIOLOGY 2003; 98:906-911 (Pubitemid 36373225)
7. Hou VY, Hirshman CA, Emala CW: Neuromuscular relaxants as antagonists for M2 and M3 muscarinic receptors. ANESTHESIOLOGY 1998; 88:744-750
8. Krombach J, Hunzelmann N, Koster F, Bischoff A, Hoffmann- Menzel H, Buzello W: Anaphylactoid reactions after cisatracurium administration in six patients. Anesth Analg 2001; 93:1257-1259, table of contents (Pubitemid 33021027)
9. Laxenaire MC: Drugs and other agents involved in anaphylactic shock occurring during anaesthesia. A French multicenter epidemiological inquiry. Annales Francaises d Anesthesie et de Reanimation 1993; 12:91-96
10. Fisher MM, Baldo BA: The incidence and clinical features of anaphylactic reactions during anesthesia in Australia. Ann Fr Anesth Reanim 1993; 12:97-104
11. Alam M, Anrep GV, Barsoum GS, Talaat M, Wieninger E: Liberation of histamine from the skeletal muscle by curare. J Physiol 1939; 95:148-158
12. Mongar JL, Whelan RF: Histamine release by adrenaline and D-tubocurarine in the human subject. J Physiol 1953; 120:146-154
13. Naguib M, Samarkandi AH, Bakhamees HS, Magboul MA, el Bakry AK: Histamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarine. Br J Anaesth 1995; 75:588-592
14. Coleridge HM, Coleridge JC, Schultz HD: Afferent pathways involved in reflex regulation of airway smooth muscle. Pharmacol Ther 1989; 42:1-63
15. Costello RW, Jacoby DB, Fryer AD: Pulmonary neuronal M2 muscarinic receptor function in asthma and animal models of hyperreactivity. Thorax 1998; 53:613-616 (Pubitemid 28335524)
16. Fryer AD, Wills-Karp M: Dysfunction of M2-muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge. J Appl Physiol 1991; 71:2255-2261
17. Fryer AD, Maclagan J: Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea pig lung. Naunyn Schmiedebergs Arch Pharmacol 1987; 335:367-371
18. Belmont MR, Lien CA, Tjan J, Bradley E, Stein B, Patel SS, Savarese JJ: Clinical pharmacology of GW280430A in humans. ANESTHESIOLOGY 2004; 100:768-773 (Pubitemid 38392561)
19. Heerdt PM, Kang R, The A, Hashim M, Mook RJ Jr, Savarese JJ: Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs. ANESTHESIOLOGY 2004; 100:846-851 (Pubitemid 38392571)
20. Savarese JJ, Belmont MR, Hashim MA, Mook RA Jr, Boros EE, Samano V, Patel SS, Feldman PL, Schultz JA, McNulty M, Spitzer T, Cohn DL, Morgan P, Wastila WB: Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: A comparison with mivacurium. ANESTHESIOLOGY 2004; 100:835-845 (Pubitemid 38392570)
21. Fryer AD, Maclagan J: Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig. Br J Pharmacol 1984; 83:973-978
22. Kron SS: Severe bronchospasm and desaturation in a child associated with rapacuronium. ANESTHESIOLOGY 2001; 94: 923-924 (Pubitemid 32429765)
23. Meakin GH, Pronske EH, Lerman J, Orr R, Joffe D, Savaree AM, Lynn AM: Bronchospasm after rapacuronium in infants and children. ANESTHESIOLOGY 2001; 94:926-927 (Pubitemid 32429767)
24. Jooste E, Zhang Y, Emala CW: Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle. ANESTHESIOLOGY 2005; 102:117-124 (Pubitemid 40082848)