Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response

PLoS Computational Biology

Volumn 6, Issue 3, 2010, Pages

  Heo, Muyoung ^a   Shakhnovich, Eugene I ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONING; PROTEINS; STOCHASTIC SYSTEMS;

ADAPTIVE EVOLUTION; ASEXUAL POPULATION; MISMATCH REPAIR; MUTATION RATES; REPAIR PROTEINS; STATIONARY PHASE; STRESSES RESPONSE; TEMPERATURE JUMP; THREE ORDERS OF MAGNITUDE; WILD TYPES;

GENES;

HOMODIMER;

AB INITIO CALCULATION; ADAPTATION; ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; EVOLUTIONARY ADAPTATION; GENE OVEREXPRESSION; GENE REPLICATION; GENETIC MODEL; GENETIC STABILITY; GENOTYPE PHENOTYPE CORRELATION; HIGH TEMPERATURE; MISMATCH REPAIR; MOLECULAR CLONING; MUTATION RATE; MUTATOR GENE; NONHUMAN; PLEIOTROPY; POPULATION GENETICS; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; STARVATION; STRESS; ANIMAL; BASE MISPAIRING; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENETIC SELECTION; GENETICS; HUMAN; MUTATION; PHYSIOLOGICAL STRESS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BASE PAIR MISMATCH; COMPUTER SIMULATION; GENETICS, POPULATION; HUMANS; MODELS, GENETIC; MUTATION; SELECTION, GENETIC; STRESS, PHYSIOLOGICAL;

EID: 77950833498     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000710     Document Type: Article

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