The sortilin-related receptor SORL1 and the amyloid cascade: A possible explanation for the concurrent elevation of CSF soluble APPα and APPβ in Alzheimer's disease

International Journal of Geriatric Psychiatry

Volumn 25, Issue 5, 2010, Pages 542-543

  Alexopoulos, P ^a   Kurz, A ^a   Lewczuk, P ^b   Kornhuber, J ^b   Wiltfang, J ^c   Maier, W ^d   Forstl H ^a   Perneczky, R ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PROTEIN ALPHA; SORL1 PROTEIN; SORTILIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BRAIN TISSUE; CEREBROSPINAL FLUID ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; HUMAN; LETTER; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; BRAIN; HUMANS; LDL-RECEPTOR RELATED PROTEINS; MEMBRANE TRANSPORT PROTEINS; RETROSPECTIVE STUDIES;

EID: 77950833469     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2349     Document Type: Letter

References (5)

1. Lewczuk P, Kamrowski-Kruck H, Peters O, et al. Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry 2008 (in press).
2. Minati L, Edginton T, Bruzzone MG, Giaccone G. Current concepts in Alzheimer's disease: a multidisciplinary review. Am J Alzheimers Dis Other Demen 2009. 24: 95-121.
3. Rohe M, Carlo AS, Breyhan H, et al. Sortilin-related receptor with Atype repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. J Biol Chem 2008. 283: 14826-14834.
4. Willnow TE, Petersen CM, Nykjaer A. VPS10P-domain receptors-regulators of neuronal viability and function. Nat Rev Neurosci 2008. 9: 899-909.
5. Zhao Y, Cui JG, Lukiw WJ. Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cells. Neuroreport 2007. 18: 1187-1191.