Microscopic and electrophysiological changes on regenerating sciatic nerves of rats treated with simvastatin

Folia Neuropathologica

Volumn 48, Issue 1, 2010, Pages 49-56

  Daglioglu, Ergun ^a   Berker, Mustafa ^b   Demirci, Mehmet ^b   Tuncel, Mürvet ^b   Karabulut, Erdem ^b   Erbengi, Aykut ^b  

^a ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Experimental; Peripheral nerve; Peripheral neuropathy; Rat; Sciatic nerve; Simvastatin

Indexed keywords

SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXOPLASM; CELL DENSITY; CELL REGENERATION; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INDUCED DISEASE; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; HISTOPATHOLOGY; MALE; MUSCLE ACTION POTENTIAL; MYELIN SHEATH; MYELINATED NERVE; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PERIPHERAL NERVE; RAT; SCIATIC NERVE; WISTAR RAT;

EID: 77950828343     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Azzouz M, Kennel PF, Warter JM, Poindron P, Borg J. Enhancement of mouse sciatic nerve regeneration by the long chain fatty alcohol, N-hexacosanol. Exp Neurol 1996; 138: 189-197. (Pubitemid 26132708)
2. Bridge PM, Ball DJ, Mackinnon SE, Nakao Y, Brandt K, Hunter DA, Hertl C. Nerve crush injuries-a model for axonotmesis. Exp Neurol 1994; 127: 284-290. (Pubitemid 24247972)
3. Chong PH, Boskovich A, Stevkovic N, Bartt RE. Statin-associated peripheral neuropathy: review of the literature. Pharmacotherapy 2004; 24: 1194-1203. (Pubitemid 39128843)
4. England JD, Viles A, Walsh JC, Stewart PM. Muscle side effects associated with simvastatin therapy. Med J Aust 1990; 153: 562- 563. (Pubitemid 20387424)
5. Gaist D, Jeppesen U, Andersen M, Garcia Rodriguez LA, Hallas J, Sindrup SH. Statins and risk of polyneuropathy: a case-control study. Neurology 2002; 58: 1333-1337. (Pubitemid 34507158)
6. Kitao A, Hirata H, Morita A, Yoshida T, Uchida A. Transient damage to the axonal transport system without wallerian degeneration by acute nerve compression. Exp Neurol 1997; 147: 248-255. (Pubitemid 27497287)
7. Lo YL, Leoh TH, Loh LM, Tan CE. Statin therapy and small fibre neuropathy: a serial electrophysiological study. J Neurol Sci 2003; 208: 105-108.
8. Nakahara G, Kuriyama M, Yoshidome H, Nagata K, Nagado T, Nakagawa M, Arimura K, Higuchi I, Osame M. Experimental simvastatin-induced myopathy in rabbits. J Neurol Sci 1992; 113: 114-117.
9. Nakahara K, Kuriyama M, Sonoda Y, Yoshidome H, Nakagawa H, Fujiyama J, Higuchi I, Osame M. Myopathy induced by HMGCoA reductase inhibitors in rabbits: a pathological, electrophysiological, and biochemical study. Toxicol Appl Pharmacol 1998; 152: 99-106. (Pubitemid 28498678)
10. Phan T, McLead JG, Pollard JD, Peiris O, Rohan A, Halpern JP. Peripheral neuropathy associated with simvastatin. J Neurol Neurosurg Psychiatry 1995; 58: 625-628.
11. Rajabally YA, Varakantam V, Abbott RJ. Disorder resembling Guillain- Barre syndrome on initiation of statin therapy. Muscle Nerve 2004;. 30: 663-666 (Pubitemid 39447292)
12. Spencer PS, Lieberman AS. Scanning electron microscopy of isolated peripheral nerve fibres. Normal surface structure and alterations proximal to neuromas. Z Zellforsch Mikrosk Anat 1971; 119: 534-51.
13. Uchio Y. Pathogenesis of acute and chronic compression neuropathy. Nippon Seikeigeka Gakkai Zasshi 1995; 69: 342-357.
14. Ziajka PE, Wehmeier T. Peripheral neuropathy and lipid-lowering therapy. South Med J 1998; 91: 667-668. (Pubitemid 28328664)