T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner

Brain

Volumn 133, Issue 4, 2010, Pages 1054-1066

  Pinschewer, Daniel D ^a,b   Schedensack, Mariann ^c   Bergthaler, Andreas ^a,b,d   Horvath, Edit ^b   Brück, Wolfgang ^c   Löhning, Max ^e   Merkler, Doron ^c  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cellular immune response; Choriomeningitis; Cytotoxic T cell response; Infection of the nervous system; T cells; Virus

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEUTRALIZING ANTIBODY; NUCLEOPROTEIN; PERFORIN; RAG1 PROTEIN; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFECTION; BRAIN TISSUE; C57BL 6 MOUSE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM; CLEARANCE; CLINICAL ASSESSMENT; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EPENDYMA; GENE ACTIVATION; HISTOPATHOLOGY; IMMUNOPATHOLOGY; INOCULATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TISSUE INJURY; VIRAL CLEARANCE; VIRUS DETECTION; VIRUS INFECTION; VIRUS TITRATION;

EID: 77950823858     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq028     Document Type: Article

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