Applications of HILIC for targeted and nontargeted LC/MS analyses in drug discovery

Journal of Separation Science

Volumn 33, Issue 6-7, 2010, Pages 923-929

  Onorato, Joelle M ^a   Langish, Robert ^a   Bellamine, Aouatef ^a   Shipkova, Petia ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Drug discovery; Endogenous profiling; Hydrophilic interaction LC MS; LC MS

Indexed keywords

BIOMOLECULES; DRUG PRODUCTS PLANTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; METABOLISM; METABOLITES; METHANOL; MOLECULES; ORGANIC SOLVENTS; PHARMACOKINETICS;

ANALYTICAL METHOD; ANALYTICAL TOOL; AQUEOUS SOLUBILITY; DRUG DISCOVERY; DRUG METABOLITES; DRUG MOLECULES; HYDROPHILIC INTERACTION; NEW APPLICATIONS; NON-TARGETED; PHARMACEUTICAL INDUSTRY; POLAR COMPOUNDS; POLAR MOLECULES; PURITY ASSESSMENT; RP-HPLC; SELECTED EXAMPLES; SMALL-MOLECULE DRUGS;

DRUG INTERACTIONS;

BIOLOGICAL MARKER;

ARTICLE; BLOOD SAMPLING; CELL ASSAY; DNA FINGERPRINTING; GLYCEMIC INDEX; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; METABOLITE; METABOLOME; NONHUMAN; PHARMACEUTICS; PHASE SEPARATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCREENING; SENSITIVITY AND SPECIFICITY; URINE; DRUG DEVELOPMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PROCEDURES;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DISCOVERY; MASS SPECTROMETRY; PHARMACOKINETICS;

EID: 77950821598     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200900659     Document Type: Article

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