-
1
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2009. CA Cancer J Clin 2009, 59:225-249.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
2
-
-
77950803748
-
-
National Comprehensive Cancer Network (NCCN) Available at:, Accessed November 3, 2009
-
National Comprehensive Cancer Network (NCCN) Available at:, Accessed November 3, 2009. http://www.nccn.org/professionals/physcian_gls/f_guidelines.asp.
-
-
-
-
3
-
-
42349093032
-
Meta-analysis of randomized trials: evaluation of benefit form gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
-
Heinemann V., Boeck S., Hinke A., et al. Meta-analysis of randomized trials: evaluation of benefit form gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer 2008, 8:82.
-
(2008)
BMC Cancer
, vol.8
, pp. 82
-
-
Heinemann, V.1
Boeck, S.2
Hinke, A.3
-
4
-
-
38549113698
-
Chemotherapy for pancreatic cancer: from metastatic disease to adjuvant therapy
-
Wolff R. Chemotherapy for pancreatic cancer: from metastatic disease to adjuvant therapy. Cancer J 2007, 13(3):175-181.
-
(2007)
Cancer J
, vol.13
, Issue.3
, pp. 175-181
-
-
Wolff, R.1
-
6
-
-
0036137690
-
Phase II study of oral capecitabine on patients with advanced or metastatic pancreatic cancer
-
Cartwright T.H., Cohn A., Varkey J., et al. Phase II study of oral capecitabine on patients with advanced or metastatic pancreatic cancer. J Clin Oncol 2002, 20(1):160-164.
-
(2002)
J Clin Oncol
, vol.20
, Issue.1
, pp. 160-164
-
-
Cartwright, T.H.1
Cohn, A.2
Varkey, J.3
-
7
-
-
34247188535
-
Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer
-
Sultana A., Smith C.T., Cunningham D., et al. Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. J Clin Oncol 2007, 25(18):2607-2615.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18
, pp. 2607-2615
-
-
Sultana, A.1
Smith, C.T.2
Cunningham, D.3
-
8
-
-
33750106459
-
Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer
-
CD002093
-
Yip D., Karapetis C., Strickland A., et al. Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer. Cochrane Database Syst Rev 2006, (3). CD002093.
-
(2006)
Cochrane Database Syst Rev
, Issue.3
-
-
Yip, D.1
Karapetis, C.2
Strickland, A.3
-
9
-
-
33645051717
-
Multicenter phase I/II study using combination of gemcitabine and docetaxel in metastasized and unresectable, locally advanced pancreatic carcinoma
-
Ridwelski K., Fahlke J., Kuhn R., et al. Multicenter phase I/II study using combination of gemcitabine and docetaxel in metastasized and unresectable, locally advanced pancreatic carcinoma. Eur J Surg Oncol 2006, 32(3):297-302.
-
(2006)
Eur J Surg Oncol
, vol.32
, Issue.3
, pp. 297-302
-
-
Ridwelski, K.1
Fahlke, J.2
Kuhn, R.3
-
10
-
-
8644240004
-
Gemcitabine combined with docetaxel for the treatment of unresectable pancreatic carcinoma
-
Jacobs A.D., Otero H., Picozzi V.J., et al. Gemcitabine combined with docetaxel for the treatment of unresectable pancreatic carcinoma. Cancer Invest 2004, 22(4):505-514.
-
(2004)
Cancer Invest
, vol.22
, Issue.4
, pp. 505-514
-
-
Jacobs, A.D.1
Otero, H.2
Picozzi, V.J.3
-
11
-
-
0344305656
-
Phase II study of gemcitabine plus docetaxel in advanced pancreatic cancer: a Hoosier Oncology Group study
-
Schneider B.P., Ganjoo K.N., Seitz D.E., et al. Phase II study of gemcitabine plus docetaxel in advanced pancreatic cancer: a Hoosier Oncology Group study. Oncology 2003, 65(3):218-223.
-
(2003)
Oncology
, vol.65
, Issue.3
, pp. 218-223
-
-
Schneider, B.P.1
Ganjoo, K.N.2
Seitz, D.E.3
-
12
-
-
77950830854
-
-
Lippincott, Williams, and Wilkins, Philadelphia
-
Skeel R. Gemcitabine: handbook of cancer chemotherapy 2003, Lippincott, Williams, and Wilkins, Philadelphia, p. 116-7. 6th edition.
-
(2003)
Gemcitabine: handbook of cancer chemotherapy
, pp. 116-117
-
-
Skeel, R.1
-
13
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
-
Burris H.A., Moore M.J., Andersen J., et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997, 15(6):2403-2413.
-
(1997)
J Clin Oncol
, vol.15
, Issue.6
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
-
14
-
-
0142121290
-
Randomized phase II comparison of dose intense gemcitabine: thirty minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
-
Tempero M., Plunkett W., Van Haperen Ruiz, et al. Randomized phase II comparison of dose intense gemcitabine: thirty minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 2003, 21(18):3402-3408.
-
(2003)
J Clin Oncol
, vol.21
, Issue.18
, pp. 3402-3408
-
-
Tempero, M.1
Plunkett, W.2
Van Haperen, R.3
-
15
-
-
20644464360
-
Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer; results of a GERCOR and GISCAD phase III trial
-
Louvet C., Labianca R., Hammel P., et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer; results of a GERCOR and GISCAD phase III trial. J Clin Oncol 2005, 23(15):3509-3516.
-
(2005)
J Clin Oncol
, vol.23
, Issue.15
, pp. 3509-3516
-
-
Louvet, C.1
Labianca, R.2
Hammel, P.3
-
16
-
-
68949114505
-
Phase III randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group
-
Poplin E., Feng Y., Berlin J., et al. Phase III randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2009, 27(23):3778-3785.
-
(2009)
J Clin Oncol
, vol.27
, Issue.23
, pp. 3778-3785
-
-
Poplin, E.1
Feng, Y.2
Berlin, J.3
-
18
-
-
33748297529
-
A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer
-
Stathopoulos G.P., Syrigos K., Aravantinos G., et al. A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer. Br J Cancer 2006, 95(5):587-592.
-
(2006)
Br J Cancer
, vol.95
, Issue.5
, pp. 587-592
-
-
Stathopoulos, G.P.1
Syrigos, K.2
Aravantinos, G.3
-
19
-
-
33748445708
-
Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer
-
Heinemann V., Quietzsh D., Gieseler F., et al. Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol 2006, 24(24):3946-3952.
-
(2006)
J Clin Oncol
, vol.24
, Issue.24
, pp. 3946-3952
-
-
Heinemann, V.1
Quietzsh, D.2
Gieseler, F.3
-
20
-
-
36049018883
-
Role of platinum agents in the management of advanced pancreatic cancer
-
Saif M.W., Kim R. Role of platinum agents in the management of advanced pancreatic cancer. Expert Opin Pharmacother 2007, 8(16):2719-2727.
-
(2007)
Expert Opin Pharmacother
, vol.8
, Issue.16
, pp. 2719-2727
-
-
Saif, M.W.1
Kim, R.2
-
21
-
-
34948888231
-
Increased survival using platinum analog combined with gemcitabine as compared to single agent gemcitabine in advanced pancreatic cancer: pooled analysis of two randomized trials the GERCOR/GISCAD intergroup study and a German multicenter study
-
Heinemann V., Labianca R., Hinke A., et al. Increased survival using platinum analog combined with gemcitabine as compared to single agent gemcitabine in advanced pancreatic cancer: pooled analysis of two randomized trials the GERCOR/GISCAD intergroup study and a German multicenter study. Ann Oncol 2007, 18(10):1652-1659.
-
(2007)
Ann Oncol
, vol.18
, Issue.10
, pp. 1652-1659
-
-
Heinemann, V.1
Labianca, R.2
Hinke, A.3
-
22
-
-
34250180939
-
Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer. A randomized multicenter, phase III trial of the Swiss Group for Clinical Cancer research and the Central European Cooperative Oncology Group
-
Hermann R., Bodoky G., Ruhstaller B., et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer. A randomized multicenter, phase III trial of the Swiss Group for Clinical Cancer research and the Central European Cooperative Oncology Group. J Clin Oncol 2007, 25:2212-2217.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2212-2217
-
-
Hermann, R.1
Bodoky, G.2
Ruhstaller, B.3
-
23
-
-
29344476191
-
Phase III randomized comparison of gemcitabine (GEM) versus gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer
-
Cunningham D., Chau I., Stocken D., et al. Phase III randomized comparison of gemcitabine (GEM) versus gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer. Eur J Cancer Suppl 2005, 3:4.
-
(2005)
Eur J Cancer Suppl
, vol.3
, pp. 4
-
-
Cunningham, D.1
Chau, I.2
Stocken, D.3
-
24
-
-
45749089796
-
Metastatic pancreatic cancer 2008: is the glass less empty?
-
Nieto J., Grossbard M., Kozuch P. Metastatic pancreatic cancer 2008: is the glass less empty?. Oncologist 2008, 13:562-576.
-
(2008)
Oncologist
, vol.13
, pp. 562-576
-
-
Nieto, J.1
Grossbard, M.2
Kozuch, P.3
-
25
-
-
67649386620
-
Emerging drugs in the treatment of pancreatic cancer
-
Mahalingam D., Kelly K., Swords R., et al. Emerging drugs in the treatment of pancreatic cancer. Expert Opin Emerg Drugs 2009, 14(2):311-328.
-
(2009)
Expert Opin Emerg Drugs
, vol.14
, Issue.2
, pp. 311-328
-
-
Mahalingam, D.1
Kelly, K.2
Swords, R.3
-
26
-
-
56249104160
-
Challenges in developing targeted therapies for pancreatic adnenocarcinoma
-
Mahalingam D., Giles F. Challenges in developing targeted therapies for pancreatic adnenocarcinoma. Expert Opin Ther Targets 2008, 12(11):1389-1401.
-
(2008)
Expert Opin Ther Targets
, vol.12
, Issue.11
, pp. 1389-1401
-
-
Mahalingam, D.1
Giles, F.2
-
28
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore M.J., Goldstein D., Hamm J., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007, 25(15):1960-1966.
-
(2007)
J Clin Oncol
, vol.25
, Issue.15
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
29
-
-
38049041406
-
Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas
-
Senderowicz A., Johnson J., Sridhara R., et al. Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas. Oncology (Williston Park). (FDA Approval Summary) 2007, 21(14):1696-1706.
-
(2007)
Oncology (Williston Park). (FDA Approval Summary)
, vol.21
, Issue.14
, pp. 1696-1706
-
-
Senderowicz, A.1
Johnson, J.2
Sridhara, R.3
-
30
-
-
77950789069
-
-
Erlotinib as a single agent therapy in patients with advanced pancreatic cancer. Presented at the ,ASCO GI Cancer Symposium. Orlando (FL), January 19-21, 2007.
-
Epelbaum R, Schnaider J, Gluzman A, et al. Erlotinib as a single agent therapy in patients with advanced pancreatic cancer. Presented at the 2007 ASCO GI Cancer Symposium. Orlando (FL), January 19-21, 2007.
-
(2007)
-
-
Epelbaum, R.1
Schnaider, J.2
Gluzman, A.3
et al4
-
32
-
-
35548941394
-
Cancer and Leukemia group B A Double blind, placebo controlled randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in pts with advanced pancreatic cancer (PC); a preliminary analysis of CALGB
-
(meeting abstracts) [abstract 4508], s
-
Kindler H.L., Niedzwiecki D., Hollis D., et al. Cancer and Leukemia group B A Double blind, placebo controlled randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in pts with advanced pancreatic cancer (PC); a preliminary analysis of CALGB. J Clin Oncol 2007, 25(18s). (meeting abstracts) [abstract 4508].
-
(2007)
J Clin Oncol
, vol.25
, Issue.18
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
-
33
-
-
32944478346
-
Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
-
Kindler H.L., Friberg G., Singh D.A., et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 2005, 23:8033-8040.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8033-8040
-
-
Kindler, H.L.1
Friberg, G.2
Singh, D.A.3
-
34
-
-
65549150854
-
Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in metastatic pancreatic cancer
-
Van Cutsem E., Ververnne W.L., Bennouna J., et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in metastatic pancreatic cancer. J Clin Oncol 2009, 27(13):2231-2237.
-
(2009)
J Clin Oncol
, vol.27
, Issue.13
, pp. 2231-2237
-
-
Van Cutsem, E.1
Ververnne, W.L.2
Bennouna, J.3
-
35
-
-
48949095510
-
A randomized, double-blind, placebo (P) controlled, multicenter phase III trial to evaluate the efficacy and safety of adding bevacizumab (B) to erlotinib (E) and gemcitabine (G) in patients (pts) with metastatic pancreatic cancer [abstract 4507]
-
2008 ASCO Annual Meeting Proceedings,
-
Vervenne W., Bennouna Y., Humblet S., et al. A randomized, double-blind, placebo (P) controlled, multicenter phase III trial to evaluate the efficacy and safety of adding bevacizumab (B) to erlotinib (E) and gemcitabine (G) in patients (pts) with metastatic pancreatic cancer [abstract 4507]. J Clin Oncol 2008, 26(15S). 2008 ASCO Annual Meeting Proceedings.
-
(2008)
J Clin Oncol
, vol.26
, Issue.15
-
-
Vervenne, W.1
Bennouna, Y.2
Humblet, S.3
-
36
-
-
39149112958
-
Sorafenib plus gemcitabine for advanced pancreatic cancer (PC): a phase II trial of the University of Chicago Phase II Consortium. 2007 ASCO Annual Meeting Proceedings Part I [abstract 4608]
-
Wallace J.A., Locker G., Nattam S., et al. Sorafenib plus gemcitabine for advanced pancreatic cancer (PC): a phase II trial of the University of Chicago Phase II Consortium. 2007 ASCO Annual Meeting Proceedings Part I [abstract 4608]. J Clin Oncol 2007, 25(18S (Suppl 20)).
-
(2007)
J Clin Oncol
, vol.25
, Issue.20 SUPPL
-
-
Wallace, J.A.1
Locker, G.2
Nattam, S.3
-
37
-
-
67649377832
-
Phase I dose findings study of sunitinib (SU) in combination with gemcitabine (G) in patients (pts) with advanced solid tumors [abstract 14522]
-
Michaelson M.D., Schwarzberg A., Ryan D.P., et al. Phase I dose findings study of sunitinib (SU) in combination with gemcitabine (G) in patients (pts) with advanced solid tumors [abstract 14522]. Clin Oncol 2008, 26(Suppl 20).
-
(2008)
Clin Oncol
, vol.26
, Issue.20 SUPPL.
-
-
Michaelson, M.D.1
Schwarzberg, A.2
Ryan, D.P.3
-
38
-
-
33750903161
-
A randomized phase II study of bevacizumab (B) and gemcitabine (G) plus cetuximab (C) or erlotinib (E) in patients (pts) with advanced pancreatic cancer (PC) [abstract 4502]. ASCO Annual Meeting Proceedings
-
S
-
Kindler H.L., Bylow K.A., Hoschester G., et al. A randomized phase II study of bevacizumab (B) and gemcitabine (G) plus cetuximab (C) or erlotinib (E) in patients (pts) with advanced pancreatic cancer (PC) [abstract 4502]. ASCO Annual Meeting Proceedings. J Clin Oncol 2006, 26(15S).
-
(2006)
J Clin Oncol
, vol.26
, Issue.15
-
-
Kindler, H.L.1
Bylow, K.A.2
Hoschester, G.3
-
39
-
-
0037280222
-
Metastatic pancreatic cancer; emerging strategies in chemotherapy and palliative care
-
El Kamar F., Grossbard M., Kozuch P. Metastatic pancreatic cancer; emerging strategies in chemotherapy and palliative care. Oncologist 2003, 8:18-34.
-
(2003)
Oncologist
, vol.8
, pp. 18-34
-
-
El Kamar, F.1
Grossbard, M.2
Kozuch, P.3
-
40
-
-
58249085318
-
Oral mTOR Inhibitor Everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
-
Wolpin B., Hezel A., Abrams T., et al. Oral mTOR Inhibitor Everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J Clin Oncol 2009, 27(2):193-198.
-
(2009)
J Clin Oncol
, vol.27
, Issue.2
, pp. 193-198
-
-
Wolpin, B.1
Hezel, A.2
Abrams, T.3
-
41
-
-
77950810103
-
Inhibition of mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: the results of two prospective studies [abstract 4621]. ASCO Annual Meeting Proceedings
-
S
-
Javle M.M., Xiong H., Reddy S., et al. Inhibition of mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: the results of two prospective studies [abstract 4621]. ASCO Annual Meeting Proceedings. J Clin Oncol 2009, 27(15S).
-
(2009)
J Clin Oncol
, vol.27
, Issue.15
-
-
Javle, M.M.1
Xiong, H.2
Reddy, S.3
-
42
-
-
36549083856
-
Phase III study of gemcitabine (G) plus cetuximab (C) versus gemcitabine in patients (pts) with locally advanced or metastatic pancreatic adenocarcinoma (PC): SWOG S0205 study [abstract LBA4509]
-
Annual Meeting Proceedings, S
-
Phillip P.A., Benedetti C., Fenoglio-Preiser M., et al. Phase III study of gemcitabine (G) plus cetuximab (C) versus gemcitabine in patients (pts) with locally advanced or metastatic pancreatic adenocarcinoma (PC): SWOG S0205 study [abstract LBA4509]. J Clin Oncol 2007, 25(18S). Annual Meeting Proceedings.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18
-
-
Phillip, P.A.1
Benedetti, C.2
Fenoglio-Preiser, M.3
-
44
-
-
54949112461
-
Second-line therapy for gemcitabine-refractory pancreatic cancer: is there a standard?
-
Almhanna K., Kim R. Second-line therapy for gemcitabine-refractory pancreatic cancer: is there a standard?. Oncology 2008, 22(10):1176-1183.
-
(2008)
Oncology
, vol.22
, Issue.10
, pp. 1176-1183
-
-
Almhanna, K.1
Kim, R.2
-
45
-
-
63849329062
-
Second-line therapy in refractory pancreatic cancer: results of a phase II study
-
Pelzer U., Stieler J., Roll L., et al. Second-line therapy in refractory pancreatic cancer: results of a phase II study. Onkologie 2009, 32(3):99-102.
-
(2009)
Onkologie
, vol.32
, Issue.3
, pp. 99-102
-
-
Pelzer, U.1
Stieler, J.2
Roll, L.3
-
46
-
-
52249103952
-
Weekly docetaxel as salvage therapy in patients with gemcitabine refractory metastatic pancreatic cancer
-
Cereda S., Reni M. Weekly docetaxel as salvage therapy in patients with gemcitabine refractory metastatic pancreatic cancer. J Chemother 2008, 20(4):509-512.
-
(2008)
J Chemother
, vol.20
, Issue.4
, pp. 509-512
-
-
Cereda, S.1
Reni, M.2
-
47
-
-
37849031303
-
Excess toxicity associated with docetaxel and irinotecan in patients with metastatic gemcitabine-refractory pancreatic cancer: results of a phase II study
-
Ko A.H., Dito E., Schillinger B., et al. Excess toxicity associated with docetaxel and irinotecan in patients with metastatic gemcitabine-refractory pancreatic cancer: results of a phase II study. Cancer Invest 2008, 26(1):47-52.
-
(2008)
Cancer Invest
, vol.26
, Issue.1
, pp. 47-52
-
-
Ko, A.H.1
Dito, E.2
Schillinger, B.3
|