WT1 expression levels at diagnosis could predict long-term time-to-progression in adult patients affected by acute myeloid leukaemia and myelodysplastic syndromes

British Journal of Haematology

Volumn 149, Issue 3, 2010, Pages 451-454

  Galimberti, Sara ^a   Ghio, Francesco ^a   Guerrini, Francesca ^a   Ciabatti, Elena ^a   Grassi, Susanna ^a   Ferreri, Maria Immacolata ^b   Petrini, Mario ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY HOSPITAL OF PISA   (Italy)

Author keywords

AML; Myelodysplastic syndromes; WT1

Indexed keywords

AZACITIDINE; CYTARABINE; DOXORUBICIN; IDARUBICIN; MESSENGER RNA; RECOMBINANT ERYTHROPOIETIN; WT1 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; CANCER SURVIVAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE NUMBER; HIGH RISK POPULATION; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; MYELODYSPLASTIC SYNDROME; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; STEM CELL TRANSPLANTATION; THROMBOCYTE COUNT;

AGED; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; WT1 PROTEINS;

EID: 77950812367     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.08063.x     Document Type: Letter

References (7)

1. Candoni, A., Tiribelli, M., Toffoletti, E., Cilloni, D., Chiarvesio, A., Michelutti, A., Simeone, E., Pipan, C., Saglio, G. Fanin, R. (2009) Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia. European Journal of Haematology, 82, 61 68.
2. Cilloni, D., Gottardi, E., Messa, F., Fava, M., Scaravaglio, P., Bertini, M., Girotto, M., Marinone, C., Ferrero, D., Gallamini, A., Levis, A. Saglio, G. Group Piedmont Study on Syndromes, Myleodysplastic 2003) Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes. Journal of Clinical Oncology, 21, 1988 1995.
3. Cilloni, D., Messa, F., Arruga, F., Defilippi, I., Gottardi, E., Fava, M., Carturan, S., Catalano, R., Bracco, E., Messa, E., Nicoli, P., Diverio, D., Sanz, M.A., Martinelli, G., Lo-Coco, F. Saglio, G. (2008) Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy. Haematologica, 93, 921 924.
4. Malcovati, L., Germing, U., Kuendgen, A., Della Porta, M.G., Pascutto, C., Invernizzi, R., Giagounidis, A., Hildebrandt, B., Bernasconi, P., Knipp, S., Strupp, C., Lazzarino, M., Aul, C. Cazzola, M. (2007) Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. Journal of Clinical Oncology, 25, 3503 3510.
5. Rosenfeld, C., Cheever, M.A. Gaiger, A. (2003) WT1 in acute leukemia, chronic myelogenous leukemia and myelodysplastic syndrome: therapeutic potential of WT1 targeted therapies. Leukemia, 17, 1301 1312.
6. Tamaki, H., Ogawa, H., Ohyashiki, K., Ohyashiki, J.H., Iwama, H., Inoue, K., Soma, T., Oka, Y., Tatekawa, T., Oji, Y., Tsuboi, A., Kim, E.H., Kawakami, M., Fuchigami, K., Tomonaga, M., Toyama, K., Aozasa, K., Kishimoto, T. Sugiyama, H. (1999) The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes. Leukemia, 13, 393 399.
7. Virappane, P., Gale, R., Hills, R., Kakkas, I., Summers, K., Stevens, J., Allen, C., Green, C., Quentmeier, H., Drexler, H., Burnett, A., Linch, D., Bonnet, D., Lister, T.A. Fitzgibbon, J. (2008) Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party. Journal of Clinical Oncology, 26, 5429 5435.