Direct HPLC enantioseparation of omeprazole and its chiral impurities: Application to the determination of enantiomeric purity of esomeprazole magnesium trihydrate

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 5, 2010, Pages 665-671

  Zanitti, Leo ^a   Ferretti, Rosella ^a   Gallinella, Bruno ^a   La Torre, Francesco ^a   Sanna, Maria Luisa ^a   Mosca, Antonina ^a   Cirilli, Roberto ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Chiralpak IA; Circular dichroism; Enantiomers; Esomeprazole; Impurities

Indexed keywords

ACETIC ACID ETHYL ESTER; ALCOHOL; DIETHYLAMINE; ESOMEPRAZOLE; OMEPRAZOLE; TERT BUTYL METHYL ETHER;

ANALYTIC METHOD; ARTICLE; CHIRALITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IMPURITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHYSICAL PHASE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; LIMIT OF DETECTION; OMEPRAZOLE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 77950810854     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.02.021     Document Type: Article

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