Cyclosporine blocks incorporation of HIV-1 envelope glycoprotein into virions

Journal of Virology

Volumn 84, Issue 9, 2010, Pages 4851-4855

  Sokolskaja, Elena ^a   Olivari, Silvia ^b   Zufferey, Madeleine ^c   Strambio De Castillia, Caterina ^b,c   Pizzato, Massimo ^c   Luban, Jeremy ^a,b,c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLOPHILIN B; ENVELOPE PROTEIN; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; SANGLIFEHRIN A; VIRUS FUSION PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VESICULAR STOMATITIS VIRUS; VIRION; VIRUS ENVELOPE; VIRUS INFECTIVITY;

ANTI-HIV AGENTS; CELL LINE; CYCLOSPORINE; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; HUMANS; T-LYMPHOCYTES; VIRION; VIRUS ASSEMBLY;

HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE; MURINE LEUKEMIA VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 77950809161     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01699-09     Document Type: Article

References (35)

1. Adachi, A., H. E. Gendelman, S. Koenig, T. Folks, R. Willey, A. Rabson, and M. A. Martin. 1986. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59:284-291. (Pubitemid 16013975)
2. Aiken, C. 1997. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. J. Virol. 71:5871-5877. (Pubitemid 27304923)
3. Berlioz-Torrent, C., B. L. Shacklett, L. Erdtmann, L. Delamarre, I. Bouchaert, P. Sonigo, M. C. Dokhelar, and R. Benarous. 1999. Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. J. Virol. 73:1350-1361. (Pubitemid 29036790)
4. Björndal, A., H. Deng, M. Jansson, J. R. Fiore, C. Colognesi, A. Karlsson, J. Albert, G. Scarlatti, D. R. Littman, and E. M. Fenyö. 1997. Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. J. Virol. 71:7478-7487. (Pubitemid 27391688)
5. Braaten, D., E. K. Franke, and J. Luban. 1996. Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription. J. Virol. 70:3551-3560. (Pubitemid 26157335)
6. Braaten, D., E. K. Franke, and J. Luban. 1996. Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses. J. Virol. 70:4220-4227. (Pubitemid 26187422)
7. Braaten, D., and J. Luban. 2001. Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. EMBO J. 20:1300-1309. (Pubitemid 32233970)
8. Brass, A. L., D. M. Dykxhoorn, Y. Benita, N. Yan, A. Engelman, R. J. Xavier, J. Lieberman, and S. J. Elledge. 2008. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319:921-926.
9. Bültmann, A., W. Muranyi, B. Seed, and J. Haas. 2001. Identification of two sequences in the cytoplasmic tail of the human immunodeficiency virus type 1 envelope glycoprotein that inhibit cell surface expression. J. Virol. 75: 5263-5276. (Pubitemid 32448549)
10. Fehr, T., J. Kallen, L. Oberer, J. J. Sanglier, and W. Schilling. 1999. Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical properties. J. Antibiot. (Tokyo) 52:474-479.
11. Franke, E. K., and J. Luban. 1996. Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction. Virology 222:279-282.
12. Franke, E. K., H. E. Yuan, and J. Luban. 1994. Specific incorporation of cyclophilin A into HIV-1 virions. Nature 372:359-362. (Pubitemid 24363437)
13. Freed, E. O., and M. A. Martin. 1995. Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix. J. Virol. 69:1984-1989.
14. Friedman, J., and I. Weissman. 1991. Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA. Cell 66:799-806. (Pubitemid 121001713)
15. Gurer, C., A. Hoglund, S. Hoglund, and J. Luban. 2005. ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity. J. Virol. 79:5557-5567. (Pubitemid 40548224)
16. Hatziioannou, T., D. Perez-Caballero, S. Cowan, and P. D. Bieniasz. 2005. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J. Virol. 79: 176-183. (Pubitemid 39648375)
17. He, J., S. Choe, R. Walker, P. Di Marzio, D. O. Morgan, and N. R. Landau. 1995. Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J. Virol. 69:6705-6711.
18. Herrera, C., P. J. Klasse, E. Michael, S. Kake, K. Barnes, C. W. Kibler, L. Campbell-Gardener, Z. Si, J. Sodroski, J. P. Moore, and S. Beddows. 2005. The impact of envelope glycoprotein cleavage on the antigenicity, infectivity, and neutralization sensitivity of Env-pseudotyped human immunodeficiency virus type 1 particles. Virology 338:154-172. (Pubitemid 40835934)
19. Hickenbottom, S. J., A. R. Kimmel, C. Londos, and J. H. Hurley. 2004. Structure of a lipid droplet protein; the PAT family member TIP47. Structure 12:1199-1207.
20. Kong, L. B., D. An, B. Ackerson, J. Canon, O. Rey, I. S. Chen, P. Krogstad, and P. L. Stewart. 1998. Cryoelectron microscopic examination of human immunodeficiency virus type 1 virions with mutations in the cyclophilin A binding loop. J. Virol. 72:4403-4407.
21. Land, A., D. Zonneveld, and I. Braakman. 2003. Folding of HIV-1 envelope glycoprotein involves extensive isomerization of disulfide bonds and conformation-dependent leader peptide cleavage. FASEB J. 17:1058-1067. (Pubitemid 36676392)
22. Liu, J., J. D. Farmer, Jr., W. S. Lane, J. Friedman, I. Weissman, and S. L. Schreiber. 1991. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807-815. (Pubitemid 121001714)
23. Lopez-Verges, S., G. Camus, G. Blot, R. Beauvoir, R. Benarous, and C. Berlioz-Torrent. 2006. Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions. Proc. Natl. Acad. Sci. U. S. A. 103:14947-14952.
24. Luban, J., K. L. Bossolt, E. K. Franke, G. V. Kalpana, and S. P. Goff. 1993. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 73:1067-1078. (Pubitemid 23180482)
25. Mammano, F., E. Kondo, J. Sodroski, A. Bukovsky, and H. G. Gottlinger. 1995. Rescue of human immunodeficiency virus type 1 matrix protein mutants by envelope glycoproteins with short cytoplasmic domains. J. Virol. 69:3824-3830.
26. Pizzato, M., E. Popova, and H. G. Gottlinger. 2008. Nef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles. J. Virol. 82:10811-10819. (Pubitemid 352691182)
27. Price, E. R., L. D. Zydowsky, M. J. Jin, C. H. Baker, F. D. McKeon, and C. T. Walsh. 1991. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Proc. Natl. Acad. Sci. U. S. A. 88:1903-1907.
28. Sanglier, J. J., V. Quesniaux, T. Fehr, H. Hofmann, M. Mahnke, K. Memmert, W. Schuler, G. Zenke, L. Gschwind, C. Maurer, and W. Schilling. 1999. Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity. J. Antibiot. (Tokyo) 52:466-473.
29. Sokolskaja, E., L. Berthoux, and J. Luban. 2006. Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J. Virol. 80:2855-2862. (Pubitemid 43346380)
30. Sokolskaja, E., D. M. Sayah, and J. Luban. 2004. Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity. J. Virol. 78: 12800-12808. (Pubitemid 39507788)
31. Staropoli, I., C. Chanel, M. Girard, and R. Altmeyer. 2000. Processing, stability, and receptor binding properties of oligomeric envelope glycoprotein from a primary HIV-1 isolate. J. Biol. Chem. 275:35137-35145.
32. Swanson, S. K., T. Born, L. D. Zydowsky, H. Cho, H. Y. Chang, C. T. Walsh, and F. Rusnak. 1992. Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B. Proc. Natl. Acad. Sci. U. S. A. 89:3741-3745.
33. Thali, M., A. Bukovsky, E. Kondo, B. Rosenwirth, C. T. Walsh, J. Sodroski, and H. G. Gottlinger. 1994. Functional association of cyclophilin A with HIV-1 virions. Nature 372:363-365. (Pubitemid 24363438)
34. Waheed, A. A., S. D. Ablan, M. K. Mankowski, J. E. Cummins, R. G. Ptak, C. P. Schaffner, and E. O. Freed. 2006. Inhibition of HIV-1 replication by amphotericin B methyl ester: selection for resistant variants. J. Biol. Chem. 281:28699-28711.
35. Wiegers, K., G. Rutter, U. Schubert, M. Grattinger, and H. G. Krausslich. 1999. Cyclophilin A incorporation is not required for human immunodeficiency virus type 1 particle maturation and does not destabilize the mature capsid. Virology 257:261-274. (Pubitemid 29391819)