PIM-1 gene RNA interference induces growth inhibition and apoptosis of prostate cancer cells and suppresses tumor progression in vivo

Journal of Surgical Oncology

Volumn 101, Issue 6, 2010, Pages 513-519

  Zhang, Tong ^a,b   Zhang, Xiaoguang ^a,c   Ding, Kejia ^b   Yang, Kou ^a   Zhang, Zhihong ^a   Xu, Yong ^a  

^a SECOND HOSPITAL OF TIANJIN MEDICAL UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c Tianjin Third Central Hospital   (China)

Author keywords

Apoptosis; PIM 1; Proliferation; Prostate cancer; RNAi

Indexed keywords

LIPOFECTAMINE; PROTEIN KINASE PIM 1; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; RNA INTERFERENCE; TECHNOLOGY; THERAPY EFFECT; TUMOR GROWTH; TUMOR MODEL; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; GENE SILENCING; HUMANS; INDICATORS AND REAGENTS; LIPIDS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 77950803910     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21524     Document Type: Article

References (19)

1. Wang Z, Bhattacharya N, Weaver M, et al.: Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis. J Vet Sci 2001;2:167-179.
2. Xu Y, Zhang T, Tang H, et al.: Overexpression of PIM-1 is a potential biomarker in prostate carcinoma. J Surg Oncol 2005;92:326-330. (Pubitemid 41779291)
3. Roh M, Gary B, Song C, et al.: Overexpression of the oncogenic kinase Pim-1 leads to genomic instability. Cancer Res 2003;63:8079-8084. (Pubitemid 37549449)
4. Burfeind P, Chernicky CL, Rininsland F, et al.: Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Proc Natl Acad Sci USA 1996;93:7263-7268. (Pubitemid 26243537)
5. Saris CJ, Domen J, Berns A: The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J 1991;10:655-664. (Pubitemid 21905520)
6. van Lohuizen M, Verbeek S, Krimpenfort P, et al.: Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell 1989;56:673-682. (Pubitemid 19065532)
7. Bachmann M, Möröy T: The serine/threonine kinase Pim-1. Int J Biochem Cell Biol 2005;37:726-730.
8. Mochizuki T, Kitanaka C, Noguchi K, et al.: Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem 1999;274:18659-18666. (Pubitemid 129519272)
9. Bachmann M, Hennemann H, Xing PX, et al.: The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): A novel role for Pim-1 at the G2/M cell cycle checkpoint. J Biol Chem 2004;279:48319-48328. (Pubitemid 39540988)
10. Lilly M, Kraft A: Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells. Cancer Res 1997;57:5348-5355. (Pubitemid 27516373)
11. Nosaka T, Kawashima T, Misawa K, et al.: STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J 1999;18:4754-4765. (Pubitemid 29415529)
12. Pircher TJ, Zhao S, Geiger JN, et al.: Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death. Oncogene 2000;19:3684-3692. (Pubitemid 30608490)
13. Wang Z, Bhattacharya N, Meyer MK, et al.: Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells. Arch Biochem Biophys 2001;390:9-18. (Pubitemid 32493565)
14. Möröy T, Grzeschiczek A, Petzold S, et al.: Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice. Proc Natl Acad Sci USA 1993;90:10734-10738. (Pubitemid 23347117)
15. Shirogane T, Fukada T, Muller JM, et al.: Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 1999;11:709-719. (Pubitemid 30030710)
16. Lilly M, Sandholm J, Cooper JJ, et al.: The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway. Oncogene 1999;18:4022-4031. (Pubitemid 29361341)
17. Dhanasekaran SM, Barrette TR, Ghosh D, et al.: Delineation of prognostic biomarkers in prostate cancer. Nature 2001;412:822-826. (Pubitemid 32801464)
18. Chen WW, Chan DC, Donald C, et al.: Pim family kinases enhance tumor growth of prostate cancer cells. Mol Cancer Res 2005;3:443-451. (Pubitemid 41232606)
19. Sui G, Soohoo C, Affar el B, et al.: A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA 2002;99:5515-5520.