Cutting edge: Responder T cells regulate human DR+ effector regulatory T cell activity via Granzyme B

Journal of Immunology

Volumn 183, Issue 8, 2009, Pages 4843-4847

  Ashley, Charles W ^a   Baecher Allan, Clare ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GRANZYME B; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

APOPTOSIS; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL KILLING; CONTROLLED STUDY; EFFECTOR CELL; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD2; ANTIGENS, CD3; APOPTOSIS; CELLS, CULTURED; GRANZYMES; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGIC FACTORS; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL; RNA, SMALL INTERFERING; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 77950788914     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900845     Document Type: Article

References (18)

1. Brunkow, M. E., E. W. Jeffery, K. A. Hjerrild, B. Paeper, L. B. Clark, S. A. Yasayko, J. E. Wilkinson, D. Galas, S. F. Ziegler, and F. Ramsdell. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27: 68-73.
2. + regulatory T cells. Nat. Immunol. 4: 330-336.
3. + T cells. Eur. J. Immunol. 35: 1773-1785.
4. Baecher-Allan, C., E. Wolf, and D. A. Hafler. 2006. MHC class II expression identifies functionally distinct human regulatory T cells. J. Immunol. 176: 4622-4631.
5. + regulatory T cells. Immunol. Rev. 212: 60-73.
6. Roncarolo, M. G., S. Gregori, M. Battaglia, R. Bacchetta, K. Fleischhauer, and M. K. Levings. 2006. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212: 28-50.
7. Grossman, W. J., J. W. Verbsky, W. Barchet, M. Colonna, J. P. Atkinson, and T. J. Ley. 2004. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21: 589-601.
8. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J. Immunol. 174: 1783-1786.
9. + regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood 106: 3068-3073.
10. + lymphoproliferative disorders of the skin compared with systemic anaplastic large cell lymphomas: an immunohistochemical study. Br. J. Dermatol. 157: 41-48.
11. Parish, C. R. 1999. Fluorescent dyes for lymphocyte migration and proliferation studies. Immunol. Cell Biol. 77: 499-508.
12. Yang, J. J., Y. Ye, A. Carroll, W. Yang, and H. W. Lee. 2001. Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr. Protein Pept. Sci. 2: 1-17.
13. Arnold, R., D. Brenner, M. Becker, C. R. Frey, and P. H. Krammer. 2006. How T lymphocytes switch between life and death. Eur. J. Immunol. 36: 1654-1658.
14. Fritzsching, B., N. Oberle, E. Pauly, R. Geffers, J. Buer, J. Poschl, P. Krammer, O. Linderkamp, and E. Suri-Payer. 2006. Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death. Blood 108: 3371-3378.
15. + responder cells by Fas-mediated apoptosis. J. Immunol. 182: 1469-1480.
16. Hirst, C. E., M. S. Buzza, C. H. Bird, H. S. Warren, P. U. Cameron, M. Zhang, P. G. Ashton-Rickardt, and P. I. Bird. 2003. The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J. Immunol. 170: 805-815.
17. Yolcu, E. S., S. Ash, A. Kaminitz, Y. Sagiv, N. Askenasy, and S. Yarkoni. 2008. Apoptosis as a mechanism of T-regulatory cell homeostasis and suppression. Immunol. Cell Biol. 86: 650-658.
18. + regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death. J. Immunol. 180: 8316-8326.