Plasma dispositions of ivermectin, doramectin and moxidectin following subcutaneous administration in rabbits

Laboratory Animals

Volumn 44, Issue 2, 2010, Pages 138-142

  Gokbulut, C ^a   Biligili, A ^b   Kart, A ^c   Turgut, C ^a  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c KAFKAS UNIVERSITY   (Turkey)

Author keywords

Doramectin; Endectocides; Ivermectin; Moxidectin; Pharmacokinetics; Rabbit

Indexed keywords

DORAMECTIN; IVERMECTIN; MOXIDECTIN; UNCLASSIFIED DRUG; VILMECTIN;

ABSENCE OF SIDE EFFECTS; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG HALF LIFE; FEMALE; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; RABBIT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTIPARASITIC AGENTS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FLUORESCENCE; HALF-LIFE; INJECTIONS, SUBCUTANEOUS; IVERMECTIN; MACROLIDES; MALE; RABBITS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 77950788198     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2009.009053     Document Type: Article

References (27)

1. Takiguchi Y, Mishna H, Okuda M, Terada M. Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties. J Antibiot 1980;33:1120-7. (Pubitemid 11201994)
2. McKellar QA, Benchaoui HA. Avermectins and milbemycins. J Vet Pharmacol Ther 1996;19:331-51.
3. Zulalian J, Stout SJ, Da Cunha AR, Garces T, Miller P. Absorption, tissue distribution, metabolism and excretion of moxidectin in cattle. J Agric Food Chem 1994;42:381-7.
4. Lanusse C, Lifschitz A, Virkel G, et al. Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. J Vet Pharmacol Ther 1997;20:91-9. (Pubitemid 27195765)
5. Curtis SK, Brooks DL. Eradication of ear mites from naturally infested conventional research rabbits using ivermectin. Lab Anim Sci 1990;40:406-8.
6. McKellar QA, Midgley DM, Galbraith EA, Scott EW, Bradley A. Clinical and pharmacological properties of ivermectin in rabbits and guinea-pigs. Vet Rec 1992;130:71-3.
7. Wagner R, Wendlberger U. Field efficacy of moxidectin in dogs and rabbits naturally infested with Sarcoptes spp, Demodex spp and Psoroptes spp mites. Vet Parasitol 2000;93:149-58.
8. Voyvoda H, Ulutas B, Eren H, Karagenc T, Bayramli G. Use of doramectin for treatment of sarcoptic mange in five Angora rabbits. Vet Dermatol 2005;16:285-8. (Pubitemid 41265200)
9. Pan BL, Wang M, Xu FR, Wang W, Dong YT, Pan ZD. Efficacy of an injectable formulation of eprinomectin against Psoroptes cuniculi, the ear mange mite in rabbits. Vet Parasitol 2006;137:386-90.
10. Kurtdede A, Karaer Z, Acar A, et al. Use of selamectin for the treatment of psoroptic and sarcoptic mite infestation in rabbits. Vet Dermatol 2007;18:18-22. (Pubitemid 46051381)
11. Kanbur M, Atalay O, Ica A, Eraslan G, Cam Y. The curative and antioxidative efficiency of doramectin and doramectin + vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits. Res Vet Sci 2008;85:291-3. (Pubitemid 351827795)
12. Mellgren M, Bergvall K. Treatment of rabbit cheyletiellosis with selamectin or ivermectin: a retrospective case study. Acta Vet Scand 2008;50:1. (Pubitemid 351237169)
13. Bassissi F, Lespine A, Alvinerie M. Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration. Parasitol Res 2006;98:244-9. (Pubitemid 43207316)
14. Gokbulut C, Nolan AM, McKellar QA. Plasma pharmacokinetics and faecal excretion of ivermectin, doramectin and moxidectin following oral administration in horses. Equine Vet J 2001;33:494-8. (Pubitemid 33662406)
15. Shoop WL, Micheal BF, Haines HW, Murphy TP, Faidley TP, Hajdu R, Thompson DR. Moxidectin and ivermectin in lambs: plasma depletion and efficacy against helminths. J Vet Pharmacol Ther 1997;20:10-19.
16. Bassissi MF, Lespine A, Alvinerie M. Enhancement of oral moxidectin bioavailability in rabbits by lipid co-administration. Parasitol Res 2004;94:188-92. (Pubitemid 39371715)
17. Dupuy J, Eeckhoutte C, Sutra JF, Mage C, Alvinerie M. Lack of sex-influence on the in vitro metabolism of ivermectin by hepatic microsomal preparations from cattle. Vet Res Commun 1999;23:223-7. (Pubitemid 129577152)
18. Dupuy J, Derlon AL, Sutra JF, Cadiergues MC, Franc M, Alvinerie M. Pharmacokinetics of selamectin in dogs after topical application. Vet Res Commun 2004;28:407-13. (Pubitemid 38992435)
19. Vanapalli SR, Hung YP, Fleckenstein L, Dzimianski MT, McCall JW. Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs. Biopharm Drug Dispos 2002;23:263-72. (Pubitemid 35203426)
20. Ndong TB, Kane Y, Diouf EH, Alvinerie M. Ivermectin in senegalese peulh sheep: influence of sex on plasma disposition. Vet Res Commun 2007;6:739-47. (Pubitemid 46951272)
21. Lo PKA, Fink DW, Williams JB, Bollinger J. Pharmacokinetic studies of ivermectin - effects of formulation. Vet Res Commun 1985;9:251-68.
22. Wicks SR, Kaye B, Weatherley AJ, et al. Effect of formulation on the pharmacokinetics and efficacy of doramectin. Vet Parasitol 1993;49:17-26. (Pubitemid 23228801)
23. Lifschitz A, Virkel G, Sallovitz J, et al. Comparative distribution of ivermectin and doramectin to parasite location tissues in cattle. Vet Parasitol 2000;87:327-38.
24. Zulalian J, Stout SJ, Da Cunha AR, Garces T, Miller P. Absorption, tissue distribution, metabolism and excretion of moxidectin in cattle. J Agric Food Chem 1994;42:381-7.
25. Hayes PW. Understanding the unique persistent anthelmintic activity of this second-generation macrocyclic lactones. Presented at the Australian Veterinarians in Industry Conference (Annual AVA Conference), Melbourne, Australia, 1994, pp 1-6.
26. Lanusse CF, Prichard P. Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics. Vet Parasitol 1993;49:123-58. (Pubitemid 23248689)
27. Fisher MH, Mrozik H. Chemistry. In: Campbell WC, ed. Ivermectin and Abamectin. New York: Springer-Verlag, 1989:1-24.