Antigen identification and characterization of lung cancer specific monoclonal antibodies produced by mAb proteomics

Journal of Proteome Research

Volumn 9, Issue 4, 2010, Pages 1834-1842

  Wang, Dongdong ^a   Hincapie, Marina ^a   Guergova Kuras, Mariana ^b   Kadas, Janos ^c   Takacs, Laszlo ^b   Karger, Barry L ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b Biosystems International SAS   (France)

^c Biosystems International Kft   (Hungary)

Author keywords

Antibody characterization; Conformational epitope; Glycoprotein; Haptoglobin; Lung cancer; MAb proteomics; Monoclonal antibody

Indexed keywords

ANTIGEN; COMPLEMENT FACTOR H; GLYCOPROTEIN; HAPTOGLOBIN; MONOCLONAL ANTIBODY; PLASMA PROTEIN; POLYCLONAL ANTIBODY;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA CHAIN; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLYCOSYLATION; HUMAN; IMMUNIZATION; IMMUNOAFFINITY CHROMATOGRAPHY; LUNG NON SMALL CELL CANCER; MASS SPECTROMETRY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEOMICS; SURFACE PLASMON RESONANCE; WESTERN BLOTTING;

ADULT; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOPROTEINS; GLYCOSYLATION; HAPTOGLOBINS; HUMANS; LUNG NEOPLASMS; MALE; MASS SPECTROMETRY; MICE; MIDDLE AGED; PROTEOMICS; TUMOR MARKERS, BIOLOGICAL;

MUS;

EID: 77950669754     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr900997z     Document Type: Article

References (28)

1. Werner, Z. J.; Hanno, L. How industry is approaching the search for new diagnostic markers and biomarkers Mol. Cell. Proteomics 2004, 3, 345 - 354
2. Chen, R.; Pan, S.; Brentnall, T. A.; Aebersold, R. Proteomic profiling of pancreatic cancer for biomarker discovery Mol. Cell. Proteomics 2005, 4, 523 - 533 (Pubitemid 40590569)
3. Rifai, N.; Gillette, M. A.; Carr, S. A. Protein biomarker discovery and validation: the long and uncertain path to clinical utility Nat. Biotechnol. 2006, 24, 971 - 983 (Pubitemid 44215392)
4. Keshishian, H.; Addona, T.; Burgess, M.; Kuhn, E.; Carr, S. Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution Mol. Cell. Proteomics 2007, 6, 2212 - 2229
5. Goldsby, R.; Kindt, T.; Osborne, B. Kuby immunology, 4 th ed.; W.H. Freeman publishing: New York, 2002; chapter 6, pp 148 - 150.
6. Uhlen, M. Mapping the human proteome using antibodies Mol. Cell. Proteomics 2007, 6, 1455 - 1456 (Pubitemid 47365443)
7. Schofield, D.; Pope, A.; Clementel, V.; Buckell, J.; Chapple, S.; Clarke, K.; Conquer, J.; Crofts, A.; Crowther, S.; Dyson, M.; Flack, G.; Griffin, G.; Hooks, Y.; Howat, W.; Kolb-Kokocinski, A.; Kunze, S.; Martin, C.; Maslen, G.; Mitchell, J.; O?Sullivan, M.; Perera, R.; Roake, W.; Shadbolt, S.; Vincent, K.; Warford, A.; Wilson, W.; Xie, J.; Young, J.; McCafferty, J. Application of phage display to high throughput antibody generation and characterization Genome Biol. 2007, 8 (R254) 1 - 18 (Pubitemid 351917495)
8. Taussig, M.; Stoevesandt, O.; Borrebaeck, C.; Bradbury, A.; Cahill, D.; Cambillau, C.; Daruvar, A.; Dubel, S.; Eichler, J.; Frank, R. ProteomeBinders: planning a european resource of affinity reagents for analysis of the human proteome Nat. Methods 2007, 4, 13 - 17
9. Agaton, C.; Galli, J.; Guthenberg, I.; Janzon, L.; Hansson, M.; Asplund, A.; Brundell, E.; Lindberg, S.; Ruthberg, I.; Wester, K.; Wurtz, D.; Hǒǒg, C.; Lundeberg, J.; St hl, S.; Pontén, F.; Uhlén, M. Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues Mol. Cell. Proteomics 2003, 2, 405 - 414
10. Gao, J.; Gao, Y.; Ju, Y.; Yang, J.; Wu, Q.; Zhang, J.; Du, X.; Wang, Z.; Song, Y.; Li, H.; Luo, X.; Ren, F.; Li, J.; Chen, Y.; Wang, L.; Xu, H.; Liu, X.; Wang, J.; Zhang, Y.; Cai, Y.; Cui, Y.; Qian, X.; He, F.; Li, M.; Sun, Q. Proteomics-based generation and characterization of monoclonal antibodies against human liver mitochondrial proteins Proteomics 2006, 6, 427 - 437
11. Ning, Y.; Wang, Y.; Li, Y.; Hong, Y.; Peng, D.; Liu, Y.; Wang, J.; Hao, W.; Tian, X.; Wu, F.; Dong, W.; Wang, L.; Wu, Q.; Liu, X.; Gao, J.; He, F.; Qian, X.; Sun, Q.; Li, M. An alternative strategy for high throughput generation and characterization of monoclonal antibodies against human plasma proteins using fractionated native proteins as immunogens Proteomics 2006, 6, 438 - 448
12. Csanky, E.; Olivova, P.; Rajnavolgyi, E.; Hempel, W.; Tardieu, N.; Katalin, E.; Jullien, A.; Malderez-Bloes, C.; Kuras, M.; Duval, M.; Nagy, L.; Scholtz, B.; Hancock, W.; Karger, B. L.; Guttman, A.; Takacs, L. Monoclonal antibody proteomics: discovery and prevalidation of chronic obstructive pulmonary disease biomarkers in a single step Electrophoresis 2007, 28, 4401 - 4406
13. Plavina, T.; Wakshull, E.; Hancock, W. S.; Hincapie, M. Combination of abundant protein depletion and multi-lectin affinity chromatography (M-LAC) for plasma protein biomarker discovery J. Proteome Res. 2007, 6, 662 - 671
14. Takacs, L.; Guttman, A.; Kuras, M. Normalization of complex analyte mixtures. European Patent EP1907865, July 14, 2006.
15. Winter, G.; Milstein, C. Man-made antibodies Nature 1991, 349, 293 - 299
16. Hardonk, M.; Duijn, P. The Mechanism of the Schiff reaction as studied with histochemical model systems J. Histochem. Cytochem. 1964, 12, 748 - 751
17. Kurosky, A.; Barnett, D.; Lee, T.; Touchstone, B.; Hay, R.; Arnott, M.; Bowman, B.; Fitch, W. Covalent structure of human haptoglobin: a serine protease homolog Proc. Natl. Acad. Sci. U.S.A. 1980, 77, 3388 - 3392
18. Dixon, G.; Black, J. Amino-acid sequence of alpha chains of human haptoglobins Nature 1968, 218, 736 - 741
19. Maeda, N.; Yang, F.; Barnett, D.; Bowman, B.; Smithies, O. Duplication within the haptoglobin Hp2 gene Nature 1984, 309, 131 - 135
20. Ye, B.; Cramer, D.; Skates, S.; Gygi, S.; Pratomo, V.; Fu, L.; Horick, N.; Licklider, L.; Schorge, J.; Berkowitz, R.; Mok, S. Haptoglobin-α subunit As potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry Clin. Cancer Res. 2003, 9, 2904 - 2911
21. Saito, S.; Murayama, Y.; Pan, Y.; Taima, T.; Fujimura, T.; Murayama, K.; Sadilek, M.; Egawa, S.; Ueno, S.; Ito, A.; Ishidoya, S.; Nakagawa, H.; Kato, M.; Satoh, M.; Endoh, M.; Arai, Y. Haptoglobin-beta chain defined by monoclonal antibody RM2 as a novel serum marker for prostate cancer Int. J. Cancer 2008, 123, 633 - 640
22. Okuyama, N.; Ide, Y.; Nakano, M.; Nakagawa, T.; Yamanaka, K.; Moriwaki, K.; Murata, K.; Ohigashi, H.; Yokoyama, S.; Eguchi, H.; Ishikawa, O.; Ito, T.; Kato, M.; Kasahara, A.; Kawano, S.; Gu, J.; Taniguchi, N.; Miyoshi, E. Fucosylated haptoglobin is a novel marker for pancreatic cancer: A detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation Int. J. Cancer 2006, 118, 2803 - 2808
23. Fujimura, T.; Shinohara, Y.; Tissot, B.; Pang, P.; Kurogochi, M.; Saito, S.; Arai, Y.; Sadilek, M.; Murayama, K.; Dell, A.; Nishimura, S.; Hakomori, S. Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects Int. J. Cancer 2008, 122, 39 - 49
24. Hoagland, L.; Campa, M.; Gottlin, E.; Herndon, J.; Patz, E. Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer Cancer 2007, 110, 2260 - 2268
25. Katz, Y.; Guterman, M.; Lahat, E. Regulation of synthesis of complement proteins in HEp2 cells Clin. Immunol. Immunopathol. 1993, 67, 117 - 123
26. Milland, J.; Yuriev, E.; Xing, P.; McKenzie, I.; Ramsland, P.; Sandrin, M. Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies Immunol. Cell Biol. 2007, 85, 623 - 632
27. Van, P.; Rudd, P.; Dwek, R.; Opdenakker, G. Concepts and principles of O-linked glycosylation Crit. Rev. Biochem. Mol. Biol. 1998, 33, 151 - 208
28. Anderson, N. L.; Anderson, N. G. The human plasma proteome: history, character, and diagnostic prospects Mol. Cell. Proteomics 2002, 1, 845 - 867