Platelet transfusion refractoriness in highly immunized beta thalassemia children undergoing stem cell transplantation

Pediatric Transplantation

Volumn 14, Issue 3, 2010, Pages 393-401

  Marktel, Sarah ^a,b   Napolitano, Sara ^a   Zino, Elisabetta ^a   Cappelli, Barbara ^a,b   Chiesa, Robert ^a,b   Poli, Francesca ^c   Crocchiolo, Roberto ^d   Ronchi, Paola ^a   Rossini, Silvano ^a   Ciceri, Fabio ^a   Roncarolo, Maria G ^a,b,e   Fleischhauer, Katharina ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Anti HLA antibodies; Children; Hematopoietic stem cell transplantation; Immunization; Thrombocytopenia; Transfusion

Indexed keywords

HLA ANTIBODY; HLA ANTIGEN CLASS 1; IMMUNOSUPPRESSIVE AGENT; BLOOD GROUP ABO SYSTEM; HLA ANTIGEN;

ACUTE GRAFT REJECTION; ADOLESCENT; ALLOIMMUNIZATION; ANTIBODY SCREENING; ANTIBODY SPECIFICITY; APLASIA; ARTICLE; BETA THALASSEMIA; BLEEDING TENDENCY; BLOOD COMPATIBILITY; BLOOD DONOR; BLOOD GROUP ABO INCOMPATIBILITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DONOR SELECTION; FEMALE; GRAFT FAILURE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA MATCHING; HUMAN; MALE; MIDDLE EAST; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PROGNOSIS; RISK FACTOR; SCHOOL CHILD; SPLENECTOMY; SPLENOMEGALY; THROMBOCYTE TRANSFUSION; THROMBOCYTOPHERESIS; ADVERSE EFFECTS; BETA-THALASSEMIA; BLOOD GROUP ABO SYSTEM; BLOOD GROUP TYPING; CHI SQUARE DISTRIBUTION; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFANT; PROCEDURES; STATISTICAL MODEL; STEM CELL TRANSPLANTATION; TRANSPLANTATION CONDITIONING;

ABO BLOOD-GROUP SYSTEM; ADOLESCENT; BETA-THALASSEMIA; BLOOD GROUPING AND CROSSMATCHING; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; FEMALE; HLA ANTIGENS; HUMANS; IMMUNOSUPPRESSION; INFANT; LINEAR MODELS; MALE; PLATELET TRANSFUSION; RISK FACTORS; STEM CELL TRANSPLANTATION; TRANSPLANTATION CONDITIONING;

EID: 77950634925     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2009.01282.x     Document Type: Article

References (21)

1. Sanz C, Freire C, Alcorta I, Ordinas A, Pereira A. Platelet-specific antibodies in HLA-immunized patients receiving chronic platelet support. Transfusion 2001 : 41 : 762 765.
2. van Marwijk Kooy M, Van Prooijen HC, Moes M, Bosma-Stants I, Akkerman JW. Use of leukocyte-depleted platelet concentrates for the prevention of refractoriness and primary HLA alloimmunization: A prospective, randomized trial. Blood 1991 : 77 : 201 205.
3. McFarland J, Menitove J, Kagen L, et al. Leukocytes reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. N Engl J Med 1997 : 337 : 1861 1870.
4. Lucarelli G, Clift RA. Marrow transplantation in thalassemia. In : Blume KG, Forman SJ, Appelbaum FR, eds. Thomas' Hematopoietic Cell Transplantation, 3rd edn.
5. Lucarelli G, Galimberti M. Marrow transplantation in patients with thalassemia responsive to iron chelation therapy. N Engl J Med 1993 : 329 : 840 844.
6. Petz LD, Garratty G, Calhoun L, et al. Selecting donors of platelets for refractory patients on the basis of HLA antibody specificity. Transfusion 2000 : 40 : 1446 1456.
7. Moroff G, Garatty G, Heal JM, et al. Selection of platelets for refractory patients by HLA matching and prospective crossmatching. Transfusion, 1992 : 32 : 633 640.
8. Delaflor-Weiss E, Mintz PD. The evaluation and management of platelet refractoriness and alloimmunization. Transfus Med Rev 2000 : 14 : 180 196.
9. Lucarelli G, Galimberti M, Polchi P, et al. Bone marrow transplantation in patients with thalassemia. N Engl J Med 1990 : 322 : 417 421.
10. Lucarelli G. Bone marrow transplantation for thalassaemia. J Intern Med Suppl 1997 : 740 : 49 52.
11. Sodani P, Gaziev D, Polchi P, et al. New approach for bone marrow transplantation in patients with class 3 thalassemia aged younger than 17 years. Blood 2004 : 104 : 1201 1203. Epub 2004 Mar 23.
12. Ishida A, Handa M, Wakui M, Okamoto S, Kamakura M, Ikeda Y. Clinical factors influencing post-transfusion platelet increment in patients undergoing hematopoietic progenitor cell transplantation - a prospective analysis. Transfusion 1998 : 38 : 839 847.
13. Colombo MB, Haworth SE, Poli F, et al. Luminex technology for anti-HLA antibody screening: Evaluation of performance and of impact on laboratory routine. Cytometry B Clin Cytom 2007 : 72 : 465 471.
14. Duguesnoy RJ, Anderson AJ, Tomasulo PA, Aster RH. ABO compatibility and platelet transfusions of alloimmunized thrombocytopenic patients. Blood 1979 : 54 : 595 599.
15. Slichter SJ. Evidence-based platelet transfusion guidelines. Hematology Am Soc Hematol Educ Program 2007 : 1 : 172 178.
16. Rebulla P. Refractoriness to platelet transfusion. Curr Opin Hematol 2002 : 9 : 516 520. Review.
17. Kekomaki R. Use of HLA- and HPA-matched platelets in alloimmunized patients. Vox Sang 1998 : 74 (Suppl. 2 359 363. Review.
18. Rebulla P. A mini review on platelet refractoriness. Haematologica 2005 : 90 : 247 253. Review.
19. Lo SC, Chang JS, Lin SW, Lin DT. Platelet alloimmunization after long-term red cell transfusion in transfusion-dependent thalassemia patients. Transfusion 2005 : 45 : 761 765.
20. Dutcher JP, Schiffer CA, Aisner J, Wiernik PH. Alloimmunization following platelet transfusion: The absence of a dose-response relationship. Blood 1981 : 57 : 395 398.
21. Lucarelli G, Clift RA, Galimberti M, et al. Marrow transplantation for patients with thalassemia: Results in class 3 patients. Blood 1996 : 87 : 2082 2088. (Pubitemid 26068926)