Lithium time-to-event trial in amyotrophic lateral sclerosis stops early for futility

The Lancet Neurology

Volumn 9, Issue 5, 2010, Pages 449-451

  Swash, Michael ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; LITHIUM CARBONATE; RILUZOLE;

AMYOTROPHIC LATERAL SCLEROSIS; AUTOPHAGY; CLINICAL TRIAL; HUMAN; LETTER; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE;

AMYOTROPHIC LATERAL SCLEROSIS; CLINICAL TRIALS AS TOPIC; HUMANS; LITHIUM; MEDICAL FUTILITY;

EID: 77950630110     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(10)70085-5     Document Type: Letter

References (9)

1. Lacomblez L., Bensimon G., Leigh P.N., Guillet P., and Meininger V. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Lancet 347 (1996) 1425-1431
2. Zocolella S., Santamato A., and Lamberti P. Current and emerging treatments for amyotrophic lateral sclerosis. Neuropsychiat Dis Treat 5 (2009) 577-595
3. Scott S., Kranz J.E., Cole J., et al. Design, power, and interpretation of studies in the standard murine model of ALS. Amyotroph Lat Scler 9 (2008) 4-15
4. Fornai F., Longone P., Cafaro L., et al. Lithium delays progression of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 105 (2008) 2052-2057
5. Fornai F., Longone P., Ferrucci M., et al. Autophagy and amyotrophic lateral sclerosis; the multiple roles of lithium. Autophagy 4 (2008) 527-530
6. Pizzasegola C., Caron I., Daleno C., et al. Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice. Amyotroph Lat Scler 10 (2009) 221-228
7. Gill A., Kidd J., Vieira F., Thompson K., and Perrin S. No benefit from chronic lithium dosing in a sibling-matched, gender-balanced, investigator-blinded trial using a standard mouse model of familial ALS. PLoS One 4 (2009) e6489
8. Aggarwal S.P., Zinman L., Simpson E., et al., the Northeast and Canadian Amyotrophic Lateral Sclerosis Consortia. Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurology (2010) 10.1016/S1474-4422(10)70068-5 published online April 6.
9. Benatar M. Lost in translation; treatment trials in the SOD1 mouse and in human amyotrophic lateral sclerosis. Neurobiol Dis 26 (2007) 1-13