Defining the contribution of non-benzene sources of benzene metabolites in urine: Implications for biomonitoring and risk assessment

Chemico-Biological Interactions

Volumn 184, Issue 1-2, 2010, Pages 299-301

  Arnold, Scott M ^a   Price, Paul S ^a   Dryzga, Mark D ^b  

^a DOW CHEMICAL COMPANY   (United States)

^b ENTRIX   (United States)

Author keywords

Benzene; Biomonitoring; Catechol; Hydroquinone; Phenol; S phenylmercapturic acid; T,t muconic acid

Indexed keywords

ACETYLCYSTEINE; BENZENE; CATECHOL; HYDROQUINONE; MUCONIC ACID; N ACETYL S PHENYLCYSTEINE; PHENOL; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL MONITORING; CONCENTRATION (PARAMETERS); ENVIRONMENTAL EXPOSURE; HUMAN; KIDNEY CONCENTRATING CAPACITY; METABOLITE; RISK ASSESSMENT;

ACETYLCYSTEINE; BENZENE; BENZENE DERIVATIVES; CATECHOLS; ENVIRONMENTAL EXPOSURE; HUMANS; HYDROQUINONES; PHENOL; RISK ASSESSMENT; SORBIC ACID;

EID: 77950628919     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.01.022     Document Type: Article

References (13)

1. McDonald T.A., Holland N.T., Skibola C., Duramad P., Smith M.T. Hypothesis: phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia. Leukemia 2001, 15:10-20.
2. American Conference of Governmental Industrial Hygienists (ACGIH), Benzene Biological Exposure Indices (BEIs), ACGIH, Cincinnati, OH, 2001.
3. Weaver V.M., Buckley T., Groopman J.D. Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods. Cancer Epidemiol. Biomarkers Prev. 2000, 9:749-755.
4. Agency for Toxic Substances and Disease Registry, Toxicological Profile for Benzene (Update), U.S. Department of Health and Human Services, Public Health Service, August 2007.
5. Kim S., Vermeulen R., Waidyanatha S., Johnson B.A., Lan Q., Rothman N., Smith M.T., Zhang L., Li G., Shen M., Yin S., Rappaport S.M. Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis 2006, 27:772-781.
6. United States Environmental Protection Agency (USEPA), Extrapolation of the Benzene Inhalation Unit Risk Estimate to the Oral Route of Exposure, NCEA-W-0517, USEPA, Washington, D.C., November 1999.
7. USEPA, Exposure Factors Handbook, 1997, http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm%3Fdeid=12464.
8. Guyton A.C., Hall J.H. Textbook of Medical Physiology 2000, W.B. Saunders Company, New York. tenth ed.
9. Kim S., Vermeulen R., Waidyanatha S., Johnson B.A., Lan Q., Smith M.T., Zhang L., Li G., Shen M., Yin S., Rothman N., Rappaport S.M. Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol. Biomarkers Prev. 2006, 15:2246-2252.
10. Boogaard P.J., van Sittert N.J. Biological monitoring of exposure to benzene: a comparison between S-phenylmercapturic acid, trans,trans-muconic acid, and phenol. Occup. Environ. Med. 1995, 52:611-620.
11. Ghittori S., Imbriani M., Maestri L., Capodaglio E., Cavalleri A. Determination of S-phenyl-mercapturic acid in urine as an indicator of exposure to benzene. Toxicol. Lett. 1999, 108:329-334.
12. Melikian A.A., Qu Q., Shore R., Li G., Li H., Jin X., Cohen B., Chen L., Li Y., Yin S., Mu R., Zhang X., Wang Y. Personal exposure to different levels of benzene and its relationships to the urinary metabolites S-phenylmercapturic acid and trans,trans-muconic acid. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 778:211-221.
13. Dor F., Dab W., Empereur-Bissonnet P., Zmirou D. Validity of biomarkers in environmental health studies: The case of PAHs and benzene. Crit. Rev. Toxicol. 1999, 29:129-168.