The effect of nasal oxytocin on pregnancy rates following intrauterine insemination: Double-blind, randomized, clinical pilot study

Archives of Gynecology and Obstetrics

Volumn 281, Issue 4, 2010, Pages 753-759

  Ochsenkühn, Robert ^a   Pavlik, Roman ^a   Hecht, Stephanie ^a   Von Schönfeldt, Viktoria ^a   Rogenhofer, Nina ^a   Thaler, Christian J ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Infertility; Intranasal; Intrauterine insemination; Oxytocin; Pregnancy rate

Indexed keywords

CHORIONIC GONADOTROPIN; ESTRADIOL; LUTEINIZING HORMONE; OXYTOCIN; PLACEBO; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FEMALE SUBFERTILITY; HUMAN; INFERTILITY; INTRAUTERINE INSEMINATION; MAJOR CLINICAL STUDY; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PILOT STUDY; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL; TERTIARY HEALTH CARE;

ADMINISTRATION, INTRANASAL; ADOLESCENT; ADULT; DOUBLE-BLIND METHOD; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; INSEMINATION, ARTIFICIAL, HOMOLOGOUS; LOGISTIC MODELS; MALE; OXYTOCICS; OXYTOCIN; PILOT PROJECTS; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY RATE; YOUNG ADULT;

EID: 77950627734     PISSN: 09320067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00404-009-1284-9     Document Type: Article

References (26)

1. Goverde AJ, McDonnell J, Vermeiden JP, Schats R, Rutten FF, Schoemaker J (2000) Intrauterine insemination or in vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-eVectiveness analysis. Lancet 355:13-18
2. Duran HE, Morshedi M, Kruger T, Oehninger S (2002) Intrauterine insemination: a systematic review on determinants of success. Hum Reprod Update 8:373-384
3. Allen NC, Herbert CM III, Maxson WS, Rogers BJ, Diamond MP, Wentz AC (1985) Intrauterine insemination: a critical review. Fertil Steril 44:569-580
4. Kunz G, Beil D, Deininger H, Wildt L, Leyendecker G (1996) The dynamics of rapid sperm transport through the female genital tract: evidence from vaginal sonography of uterine peristalsis and hysterosalpingoscintigraphy. Hum Reprod 11:627-632
5. Kunz G, Beil D, Deininger H, Einspanier A, Mall G, Leyendecker G (1997) The uterine peristaltic pump. Normal and impeded sperm transport within the female genital tract. Adv Exp Med Biol 424:267-277
6. Leyendecker C, Kunz G, Wildt L, Beil D, Deininger H (1996) Uterine hyperperistalsis and dysperistalsis as dysfunctions of the mechanism of rapid sperm transport in patients with endometriosis and infertility. Hum Reprod 11:1542-1551
7. Wildt L, Kissler S, Licht P, Becker W (1998) Sperm transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy and Doppler sonography. Hum Reprod Update 4:655-666
8. Kunz G, Noe M, Herbertz M, Leyendecker G (1998) Uterine peristalsis during the follicular phase of the menstrual cycle: effect of oestrogen, antioestrogen and oxytocin. Hum Reprod Update 4:647-654
9. Gimpl G, Fahrenholz F (2001) The oxytocin receptor system: structure, function and regulation. Physiol Rev 81:629-683
10. Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W, Davidson JM (1987) Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab 64:27-31
11. Kunz G (2007) Oxytocin-a stimulator of directed sperm transport in humans. Reprod Biomed Online 14:32-39
12. Zervomanolakis I, Ott HW, Hadziomerovic D, Mattle V, Seeber BE, Virgolini I, Heute D, Kissler S, Leyendecker G, Wildt L (2007) Physiology of upward transport in the human female genital tract. Ann NY Acad Sci 1101:1-20
13. Du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG, Gordon S (1953) The synthesis of oxytocin. J Am Chem Soc 75:4879-4880
14. Zingg HH, Rozen F, Chu K, Larcher A, Arslan A, Richard S, Lefèbvre D (1995) Oxytocin and oxytocin receptor gene expression in the uterus. Recent Prog Horm Res 50:255-273
15. Takeda S, Kuwabara Y, Mizuno M (1989) Metabolic clearance rate of oxytocin in human subjects. Nippon Naibunpi Gakkai Zasshi 65:182-189
16. Reyden G, Sjöholm I (1971) The metabolism of oxytocin in pregnant and non-pregnant women. Acta Obstet Gynecol Scand Suppl Suppl 9:37
17. Baumgarten K, Hofhansl W (1959) Synthocinon in the therapy and prophylaxis of mastitis puerperalis. Geburtshilfe Frauenheilk 19:913-921
18. Hendricks CH, Pose SV (1961) Intranasal oxytocin in obstetrics. JAMA 175:384-387
19. Pena FJ, Dominguez JC, Carbajo M, Anel L, Alegre B (1998) Treatment of swine summer infertility syndrome by means of oxytocin under Weld conditions. Theriogenology 49:829-836
20. Rasch K, Schoon HA, Sieme H, Klug E (1996) Histomorphological endometrial status and influence of oxytocin in the uterine drainage and pregnancy rate in mares. Equine Vet J 28:455-460
21. Landgraf R (1985) Plasma oxytocin concentration in man after different routes of administration of synthetic oxytocin. Exp Clin Endocrinol 85:245-248
22. Blaicher W, Gruber D, Bieglmayer C, Blaicher AM, Knogler W, Huber JC (1999) The role of oxytocin in relation to female sexual arousal. Gynecol Obstet Invest 47:125-126
23. HO W (1999) Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge University Press, Cambridge
24. Tomlinson MJ, Amissah-Arthur JB, Thompson KA, Kasraie JL, Bentick B (1996) Prognostic indicators for intrauterine insemination (IUI): statistical model for IUI success. Hum Reprod 11:1892-1896
25. Ombelet W, Vandeput H, Van der Putte G, Cox A, Janssen M, Jacobs P, Bosmans E, Steeno O, Kruger T (1997) Intrauterine insemination after ovarian stimulation with clomiphene citrate: predictive potential of inseminating motile count and sperm morphology. Hum Reprod 12:1458-1463
26. Campana A, Sakkas D, Stalberg A, Bianchi PG, Comte I, Pache T, Walker D (1996) Intrauterine insemination: evaluation of the results according to woman's age, sperm quality, total sperm count per insemination and life table analysis. Hum Reprod 11:732-736