Hypervitaminosis A Inducing Intra-hepatic Cholestasis-A Rare Case Report

Experimental and Molecular Pathology

Volumn 88, Issue 2, 2010, Pages 324-325

  Ramanathan, Vivek S ^a   Hensley, Gary ^a   French, Samuel ^b   Eysselein, Victor ^b   Chung, David ^b   Reicher, Sonya ^b   Pham, Binh ^b  

^a ST MARY MEDICAL CENTER   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Cholestasis; Herbalife; Toxicity; Vitamin A

Indexed keywords

ALKALINE PHOSPHATASE; BILIRUBIN; MULTIVITAMIN; RETINOL;

ADULT; ARTICLE; BILE DUCT OBSTRUCTION; CASE REPORT; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; HEPATOMEGALY; HUMAN; INTRAHEPATIC CHOLESTASIS; JAUNDICE; LIVER BIOPSY; LIVER NECROSIS; LIVER TOXICITY; MALE; PRURITUS; RETINOL INTOXICATION; VITAMIN SUPPLEMENTATION;

CHOLESTASIS, INTRAHEPATIC; EPHEDRA; HUMANS; HYPERVITAMINOSIS A; JAUNDICE; MALE; MIDDLE AGED; PRURITUS; VACUOLES; VITAMIN A; VITAMINS;

EID: 77950627143     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.11.007     Document Type: Article

References (12)

1. Abril E., Sim W., Earnest D. Lymphokines and not vitamin A cause direct activation of Kupffer cells in hypervitaminosis A. Gastroenterology 1989, 96:A569.
2. Ballardini G., Giostra F., Groff P., Mancini R., Jezequel A.M., Bianchi F.B. In vivo synthesis of laminin and type III collagen by Ito cells in dimethyl nitrosamin (DMN) induced rat liver cirrhosis. J. Hepatol. 1989, 9:S5.
3. Becker P., Maurer B., Schirmacher P., Waldherr R., et al. Vitamin A induced cholestatic hepatitis: a case report. Z. Gastroenterol. 2007, 45:1063-1066.
4. Cheruvattath R., Orrego M., Gautam M., et al. Vitamin A toxicity: when one a day doesn't keep the doctor away. Liver Transplatation 2006, 12:1888-1891.
5. Geubel A.P., De Galocsy, Alves, et al. Liver damage caused by therapeutic vitamin A administration: estimate of dose related toxicity in 41 cases. Gastroenterology 1991, 100:1701-1709.
6. Jacques E.A., Buschmann J., Layden T.J. The histopathological progression of vitamin a induced hepatic injury. Gastroenterology 1979, 76:599-602.
7. Kent F., Inouze T., Baker R., Minik D.T., Popper H. Vitamin A containing lipocytes and formation of type III collagen in liver injury. Proc. Natl. Acad. Sci. USA 1976, 73:3719-3722.
8. Kim C., Leo M.A., Lowe N., Lieber C.S. Effects of vitamin A and ethanol on liver plasma membrane fluidity. Hepatology 1988, 8:735-741.
9. Le Marchand P., Benatre A., Metman E.H., et al. Cirrhosis induced by vitamin A. Gastroenterol. Clin. Bio. 1984, 8:116-120.
10. Leo M.A., Arai M., Sato M., Lieber C.S. Hepatoxicity of vitamin A and ethanol in the rat. Gastroenterology 1982, 82:194-205.
11. Mobley S.A., Sim W., Sipes I.G. Repeated exposure to subclinical doses of hepatotoxicant enhances liver injury with hypervitaminosis A: a possible cause for chronic liver disease. Gastroenterology 1989, 96:A689.
12. Sim W., Abril E., Earnest D. Mechanisms of Kupffer cell activation in hypervitaminosis A. Cells of the hepatic sinusoid 1989, 91-93. The Kupffer cell foundation, Riiswijk. E. Wisse, D. Knook, K. Decker (Eds.).