Symptomatic bradycardia with oral aripiprazole and oral ziprasidone

Annals of Pharmacotherapy

Volumn 44, Issue 4, 2010, Pages 760-763

  Snarr, Brian S ^a   Phan, Stephanie V ^b   Garner, Amy ^a   VandenBerg, Amy M ^b   Barth, Kelly S ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Acute manic episode; Antipsychotics; Aripiprazole; Bipolar disorder; Bradycardia; Mania; Ziprasidone

Indexed keywords

ARIPIPRAZOLE; LITHIUM CARBONATE; ZIPRASIDONE;

ADULT; ARTICLE; BIPOLAR MANIA; CASE REPORT; DELUSION; DIFFERENTIAL DIAGNOSIS; DIZZINESS; DRUG DOSE INCREASE; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; EMERGENCY WARD; EVENING DOSAGE; FEMALE; GRANDIOSE DELUSION; HEART RATE; HUMAN; MANIA; PATIENT COMPLIANCE; PATIENT REFERRAL; PRIORITY JOURNAL; QT INTERVAL; SINUS BRADYCARDIA; SYNCOPE;

ADOLESCENT; ANTIMANIC AGENTS; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; BRADYCARDIA; DELUSIONS; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; LITHIUM CARBONATE; PIPERAZINES; PSYCHOTIC DISORDERS; QUINOLONES; THIAZOLES;

EID: 77950621780     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1M621     Document Type: Article

References (17)

1. Pitner JK, Mintzer JE, Pennypacker LC, et al. Efficacy and adverse effects of clozapine in four elderly psychotic patients. J Clin Psychiatry 1995;56:180-185
2. Chen CC, Tsai JH, Yang P, et al. Bradyarrhythmic shock associated with olanzapine (letter). Aust N Z J Psychiatry 2007;41:89. (Pubitemid 46705587)
3. Markowitz JS, DeVane CL, Boulton DW, et al. Hypotension and brady- cardia in a healthy volunteer following a single 5 mg dose of olanzapine. J Clin Pharmacol 2002;42:104-106 DOI 10.1177/0091270002042001013 (Pubitemid 34038376)
4. Goyal RS, Goyal SB. Symptomatic bradyarrhythmia secondary to risperidone (letter). Am J Psychiatry 2003;160:2243. DOI 10.1176/appi.ajp.160.12.2243
5. Tran KT, Golden P, Lark T, et al. Bradycardia at low doses of risperidone (letter). Am J Psychiatry 2004;161:2325-2326 DOI 10.1176/appi.ajp.161.12.2325-a (Pubitemid 39587306)
6. Janse A, Marijnissen RM. Quetiapine-induced bradycardia without QT interval prolongation in an elderly woman (letter). Prim Care Companion J Clin Psychiatry 2009;11:172-173 DOI 10.4088/PCC.08l00683
7. Lee TW, Tsai SJ, Hwang JP. Severe cardiovascular side effects of olanza- pine in an elderly patient: case report. Int J Psychiatry Med 2003;33:399-401. DOI 10.2190/U99G-XDML-0GRG-BYE0 (Pubitemid 38580417)
8. Pedrosa Gil F, Grohmann R, Ruther E. Asymptomatic bradycardia associated with amisulpride. Pharmacopsychiatry 2001;34:259-261 (Pubitemid 33089241)
9. Goldberger ZD. Sinoatrial block in lithium toxicity. Am J Psychiatry 2007;164:831-832 DOI 10.1176/appi.ajp.164.5.831 (Pubitemid 46808548)
10. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-245 (Pubitemid 12149145)
11. Prescribing information. Abilify (aripiprazole). Tokyo: Bristol-Myers Squibb, Otsuka America Pharmaceutical, Inc., November 2009.
12. Prescribing information. Geodon (ziprasidone). New York: Roerig, Division of Pfizer Inc., November 2009.
13. Bentley ML, Biscardi FH, Butcher C, Levitov A. Inadvertent administration of intravenous ziprasidone leading to bradycardia and QT interval prolongation (letter). Ann Pharmacother 2008;42:902-903 DOI 10.1345/aph.1L170 (Pubitemid 351778099)
14. Haddad PM, Anderson IM. Antipsychotic-related QTc prolongation, tor- sade de pointes and sudden death. Drugs 2002;62:1649-1671 DOI 10.2165/00003495- 200262110-00006
15. Jordan D. Vagal control of the heart: central serotonergic (5-HT) mechanisms. Exp Physiol 2005;90:175-181 DOI 10.1113/expphysiol.2004.029058 (Pubitemid 40364795)
16. Meltzer HY, Sumiyoshi T. Does stimulation of 5-HT(1A) receptors improve cognition in schizophrenia? Behav Brain Res 2008;195:98-102. DOI 10.1016/j.bbr.2008.05.016
17. Hatab SA, Futuro-Neto HA, Pires JG. Are 5-HT1A receptors involved in the control of reflex bradycardia induced by intracoronary injection of contrast medium in humans? Braz J Med Biol Res 1996;29:769-772 (Pubitemid 26225693)