Tumorigenicity of human induced pluripotent stem cells depends on the balance of gene expression between p21 and p53

Hepatology

Volumn 51, Issue 3, 2010, Pages 1088-1089

  Moriguchi, Hisashi ^a,b,c   Chung, Raymond T ^b   Sato, Chifumi ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; VIRUS VECTOR;

CARCINOGENICITY; CELL DENSITY; CELL DIFFERENTIATION; CELL TRANSFORMATION; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; LETTER; LIVER CELL; LIVER DISEASE; MICROVASCULATURE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; STEM CELL; TERATOMA; VIRUS GENE; WESTERN BLOTTING;

CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; ONCOGENE PROTEIN P21(RAS); TUMOR SUPPRESSOR PROTEIN P53;

EID: 77950620501     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23396     Document Type: Letter

References (5)

1. Si-Tayeb K, Noto FK, Nagaoka M, Li J, Battle MA, Duris C, et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. HEPATOLOGY 2009; doi:10.1002/hep.23354.
2. Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009;324:797-801.
3. Moriguchi H, Chung RT, Sato C. An indicator in order to evaluate the risk for cancerous transformations of human induced pluripotent stem cells. HEPATOLOGY 2009; doi:10.1002/hep.23379.
4. Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nature Biotechnol 2008;26:101-106.
5. Rowland BD, Bernards R, Peeper DS. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 2005;7:1074-1082.