Visual assessment of perfusion-diffusion mismatch is inadequate to select patients for thrombolysis for the epithet investigators

Cerebrovascular Diseases

Volumn 29, Issue 6, 2010, Pages 592-596

  Campbell, Bruce C V ^a   Christensen, Søren ^a   Foster, Sarah J ^a   Desmond, Patricia M ^a   Parsons, Mark W ^c   Butcher, Kenneth S ^e   Barber, P Alan ^f   Levi, Christopher R ^c   Bladin, Christopher F ^d   Donnan, Geoffrey A ^b   Davis, Stephen M ^a,g  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY OF ALBERTA   (Canada)

^f UNIVERSITY OF AUCKLAND   (New Zealand)

^g ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Ischemic penumbra; Stroke; Tissue plasminogen activator

Indexed keywords

ALTEPLASE; PLACEBO;

AREA UNDER THE CURVE; ARTICLE; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; BRAIN MAPPING; BRAIN PERFUSION; CLINICAL TRIAL; CONE BEAM COMPUTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT SELECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; VISUAL ORIENTATION;

BRAIN; CEREBROVASCULAR CIRCULATION; DIFFUSION MAGNETIC RESONANCE IMAGING; DOUBLE-BLIND METHOD; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; OBSERVER VARIATION; PATIENT SELECTION; REPRODUCIBILITY OF RESULTS; STROKE; THROMBOLYTIC THERAPY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 77950619512     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000311080     Document Type: Article

References (14)

1. Donnan GA, Baron JC, Ma H, Davis SM: Penumbral selection of patients for trials of acute stroke therapy. Lancet Neurol 2009; 8: 261-269.
2. Davis SM, Donnan GA: Using mismatch on MRI to select thrombolytic responders: an attractive hypothesis awaiting confirmation. Stroke 2005; 36: 1106-1107.
3. Warach S: Thrombolysis in stroke beyond three hours: targeting patients with diffusion and perfusion MRI. Ann Neurol 2002; 51: 11-13.
4. Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, Bammer R, Kakuda W, Lansberg MG, Shuaib A, Coplin W, Hamilton S, Moseley M, Marks MP: Magnetic resonance imaging profiles predict clinical response to early reperfusion: the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) study. Ann Neurol 2006; 60: 508-517.
5. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, Barber PA, Bladin C, de Silva DA, Byrnes G, Chalk JB, Fink JN, Kimber TE, Schultz D, Hand PJ, Frayne J, Hankey G, Muir K, Gerraty R, Tress BM, Desmond PM: Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 2008; 7: 299-309.
6. Butcher KS, Parsons M, MacGregor L, Barber PA, Chalk J, Bladin C, Levi C, Kimber T, Schultz D, Fink J, Tress B, Donnan G, Davis S: Refining the perfusion-diffusion mismatch hypothesis. Stroke 2005; 36: 1153-1159.
7. Kim JT, Yoon W, Park MS, Nam TS, Choi SM, Lee SH, Kim BC, Kim MK, Cho KH: Early outcome of combined thrombolysis based on the mismatch on perfusion CT. Cerebrovasc Dis 2009; 28: 259-265.
8. Sølling C, Hjort N, Ashkanian M, Østergaard L, Andersen G: Safety and efficacy of MRI-based selection for recombinant tissue plasminogen activator treatment: responder analysis of outcome in the 3-hour time window. Cerebrovasc Dis 2009; 27: 223-229.
9. Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, Kaste M, Lipka LJ, Pedraza S, Ringleb PA, Rowley HA, Schneider D, Schwamm LH, Leal JS, Söhngen M, Teal PA, Wilhelm-Ogunbiyi K, Wintermark M, Warach S: Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol 2009; 8: 141-150.
10. Hjort N, Butcher K, Davis SM, Kidwell CS, Koroshetz WJ, Rother J, Schellinger PD, Warach S, Østergaard L: Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct. Stroke 2005; 36: 388-397.
11. Byrt T, Bishop J, Carlin JB: Bias, prevalence and kappa. J Clin Epidemiol 1993; 46: 423-429.
12. Coutts SB, Simon JE, Tomanek AI, Barber PA, Chan J, Hudon ME, Mitchell JR, Frayne R, Eliasziw M, Buchan AM, Demchuk AM: Reliability of assessing percentage of diffusion- perfusion mismatch. Stroke 2003; 34: 1681-1683.
13. Olivot JM, Mlynash M, Thijs VN, Kemp S, Lansberg MG, Wechsler L, Bammer R, Marks MP, Albers GW: Optimal T max threshold for predicting penumbral tissue in acute stroke. Stroke 2009; 40: 469-475.
14. Christensen S, Campbell B, Perez de la Ossa N, Lansberg M, Straka M, de Silva D, Nagakane Y, Ogata T, Mlynash M, Bammer R, Olivot JM, Desmond P, Albers GW, Donnan GA, Davis SM: Optimal perfusion thresholds for prediction of tissue destined for infarction in the combined EPITHET and DEFUSE dataset. Stroke 2010;41:e44.