Targeted inactivation of EGF receptor inhibits renal collecting duct development and function

Journal of the American Society of Nephrology

Volumn 21, Issue 4, 2010, Pages 573-578

  Zhang, Zhao ^a   Pascuet, Elena ^b   Hueber, Pierre Alain ^c   Chu, Leelee ^a   Bichet, Daniel G ^d   Lee, Tang Cheng ^e   Threadgill, David W ^e   Goodyer, Paul ^a,b,c  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b Departments of Human Genetics   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; HOMOZYGOTE; KIDNEY COLLECTING TUBULE; KIDNEY CONCENTRATING CAPACITY; KIDNEY DEVELOPMENT; KIDNEY FUNCTION; KIDNEY MEDULLA; KIDNEY PAPILLA; KIDNEY TUBULE CELL; MALE; MOUSE; NONHUMAN; POLYURIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; WATER DEPRIVATION;

EID: 77950615161     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2009070719     Document Type: Article

References (26)

1. Cybulsky AV, Goodyer PR, McTavish AJ: Epidermal growth factor receptor activation in developing rat kidney. Am J Physiol 267: F428-F436, 1994
2. Sibilia M, Wagner EF: Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269: 234-238, 1995
3. Threadgill DW, Dlugosz AA, Hansen LA, Ten-nenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, et al.: Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant pheno-type. Science 269: 230-234, 1995
4. Bernardini N, Bianchi F, Lupetti M, Dolfi A: Immunohistochemical localization of the epidermal growth factor, transforming growth factor alpha, and their receptor in the human mesonephros and metanephros. Dev Dyn 206: 231-238, 1996
5. Sakurai H, Tsukamoto T, Kjelsberg CA, Cantley LG, Nigam SK: EGF receptor li-gands are a large fraction of in vitro branching morphogens secreted by embryonic kidney. Am J Physiol 273: F463-F472, 1997
6. Zhao H, Kegg H, Grady S, Truong HT, Robinson ML, Baum M, Bates CM: Role of fibro-blast growth factor receptors 1 and 2 in the ureteric bud. Dev Biol 276: 403-415, 2004
7. Shakya R, Watanabe T, Costantini F: The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis. Dev Cell 8: 65-74, 2005
8. Ishibe S, Karihaloo A, Ma H, Zhang J, Marlier A, Mitobe M, Togawa A, Schmitt R, Czyczk J, Kashgarian M, Geller DS, Thorgeirsson SS, Cantley LG: Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development 136: 337-345, 2009
9. Marquez MG, Cabrera I, Serrano DJ, Sterin-Speziale N: Cell proliferation and morpho-metric changes in the rat kidney during postnatal development. Anat Embryol (Berl) 205: 431-440, 2002
10. Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP: A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136: 161-171, 2009
11. Bichet DG, Birnbaumer M, Lonergan M, Arthus MF, Rosenthal W, Goodyer P, Nivet H, Benoit S, Giampietro P, Simonetti S, et al.: Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus. Am J Hum Genet 55: 278-286, 1994
12. Lin SH, Bichet DG, Sasaki S, Kuwahara M, Arthus MF, Lonergan M, Lin YF: Two novel aquaporin-2 mutations responsible for congenital nephrogenic diabetes insipidus in Chinese families. J Clin Endocrinol Metab 87: 2694-2700, 2002
13. Kihara M, Umemura S, Sumida Y, Yokoyama N, Yabana M, Nyui N, Tamura K, Murakami K, Fukamizu A, Ishii M: Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int 53: 548-555, 1998
14. Klein JD, Le Quach D, Cole JM, Disher K, Mongiu AK, Wang X, Bernstein KE, Sands JM: Impaired urine concentration and absence of tissue ACE: Involvement of medullary transport proteins. Am J Physiol Renal Physiol 283: F517-F524, 2002
15. Oliverio MI, Best CF, Kim HS, Arendshorst WJ, Smithies O, Coffman TM: Angiotensin II responses in AT1A receptor-deficient mice: A role for AT1B receptors in blood pressure regulation. Am J Physiol 272: F515-F520, 1997 (Pubitemid 27382231)
16. Oliverio MI, Delnomdedieu M, Best CF, Li P, Morris M, Callahan MF, Johnson GA, Smithies O, Coffman TM: Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. Am J Physiol Renal Physiol 278: F75-F82, 2000
17. Oliverio MI, Kim HS, Ito M, Le T, Audoly L, Best CF, Hiller S, Kluckman K, Maeda N, Smithies O, et al.: Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci USA 95: 15496-15501, 1998
18. Takahashi N, Lopez ML, Cowhig JE Jr, Taylor MA, Hatada T, Riggs E, Lee G, Gomez RA, Kim HS, Smithies O: Ren1c homozy-gous null mice are hypotensive and poly-uric, but heterozygotes are indistinguishable from wild-type. J Am Soc Nephrol 16: 125-132, 2005
19. Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, Fogo A, Ut-sunomiya H, Inagami T, Ichikawa I: Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest 101: 755-760, 1998
20. Yosypiv IV, Schroeder M, El-Dahr SS: Angio-tensin II type 1 receptor-EGF receptor crosstalk regulates ureteric bud branching morphogenesis. J Am Soc Nephrol 17: 1005-1014, 2006
21. Srinivas S, Goldberg MR, Watanabe T, D'Agati V, al-Awqati Q, Costantini F: Expression of green fluorescent protein in the ureteric bud of transgenic mice: A new tool for the analysis of ureteric bud morphogenesis. Dev Genet 24: 241-251, 1999
22. Lee TC, Threadgill DW: Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis 47: 85-92, 2009
23. Dziarmaga A, Eccles M, Goodyer P: Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice. J Am Soc Nephrol 17: 1568-1575, 2006
24. Chew JL, Chua KY: Collection of mouse urine for bioassays. Lab Anim (NY) 32: 48-50, 2003
25. Bichet DG, Arthus MF, Barjon JN, Lonergan M, Kortas C: Human platelet fraction argin-ine-vasopressin: Potential physiological role. J Clin Invest 79: 881-887, 1987
26. Kokubo T, Takahashi M, Furukawa F, Nagano K, Hayashi Y, Takahashi T: A comparative histometrical analysis of renal inner medulla of man, swine, dog and hamster. Tohoku J Exp Med 142: 77-88, 1984