Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid-induced apoptosis

Liver International

Volumn 30, Issue 2, 2010, Pages 284-297

  Zucchini Pascal, Nathalie ^a   de Sousa, Georges ^a   Pizzol, Jérôme ^a   Rahmani, Roger ^a  

^a CEMAGREF   (France)

Author keywords

Apoptosis; Cholestasis; DCA; Hepatocytes; Necrosis; PXR; Toxicology

Indexed keywords

BILE ACID; CASPASE; CLOTRIMAZOLE; COLLAGENASE; DEOXYCHOLIC ACID; GLYCOCHENODEOXYCHOLIC ACID; LACTATE DEHYDROGENASE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PREGNANE X RECEPTOR; PROPIDIUM IODIDE; PROTEIN BCL XL; PROTEIN KINASE B;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL ISOLATION; CELL PROTECTION; CHOLESTASIS; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; ENZYME SUBSTRATE; LIVER CELL; LIVER CELL CULTURE; LIVER PROTECTION; MALE; NONHUMAN; PHASE CONTRAST MICROSCOPY; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; STAINING; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CHOLAGOGUES AND CHOLERETICS; CLOTRIMAZOLE; CYTOPROTECTION; DEOXYCHOLIC ACID; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; GLYCOCHENODEOXYCHOLIC ACID; HEPATOCYTES; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, STEROID;

EID: 77950611899     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02108.x     Document Type: Article

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