Inhibitory effect of Crocus sativus (saffron) on histamine (H1) receptors of guinea pig tracheal chains

Pharmazie

Volumn 65, Issue 4, 2010, Pages 300-305

  Boskabady, M H ^a   Ghasemzadeh Rahbardar, M ^b   Nemati, H ^b   Esmaeilzadeh, M ^b  

^a Medical Science University   (Iran)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTIHISTAMINIC AGENT; ATROPINE; CHLORPHENIRAMINE; CROCUS SATIVUS EXTRACT; HISTAMINE H1 RECEPTOR; MUSCLE RELAXANT AGENT; PROPRANOLOL; SODIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG EFFECT; GUINEA PIG; MALE; MUSCLE RELAXATION; NONHUMAN; TRACHEA;

ALGORITHMS; ANIMALS; CHLORPHENIRAMINE; CROCUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GUINEA PIGS; HISTAMINE; HISTAMINE H1 ANTAGONISTS; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PLANT EXTRACTS; RECEPTORS, HISTAMINE H1; TRACHEA; WATER;

EID: 77950609653     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2010.9760     Document Type: Article

References (23)

1. Abdullaev FJ, Ferenkel GD (1992) Effects of saffron on cell colony formation and cellular nucleic acid and protein synthesis. Biofactors 3: 201-204.
2. Abdullaev FJ (1993) Biological effects of saffron. Biofactors 4: 83-86.
3. Abe K, Sugiura M,Yamaguchi,S, ShoyamaY, SaitoH(1999) Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo. Brain Res 851: 287-289. (Pubitemid 30038160)
4. Ariens EJ (1987) Pharmacology of the airway smooth muscle. In: Nadel JA, Pauwels R, Snashall PD (eds.), Bronchial hyperresponsiveness, London: Blackwell Scientific Publications, pp. 7-23.
5. Arunlakshana O, Schild HO (1959) Some quantitative use of drug antagonist. Br J Phamacol Chemother 14: 48-58.
6. Boskabady MH, Aslani MR (2006) Relaxant effect of Crocus sativus on guinea pig tracheal chains and its possible mechanisms. J Pharm Pharmacol 58: 1358-1390.
7. Escribano J, Alonso GL, Coca-Prados M, Fernandez JA (1996) Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 100: 23-30.
8. Fatehi M, Rashidabady T, Fatehi-Hassanabad Z (2003) Effects of Crocus sativus petals extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol 84: 199-203.
9. Holroyde MC (1986) The influence of epithelium on the responsiveness of guinea pig isolated trachea. Br J Phamacol 87: 501-507.
10. Hosseinzadeh H, Karimi GH, Niapoor M (2004) Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice. Acta Horticulturae (ISHS) 650: 435-434.
11. Hosseinzadeh H, Khosravan V (2002) Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch of Iran Med 5: 44-47. (Pubitemid 34591502)
12. Hosseinzadeh H, Younesi HM (2002) Antinociceptive and antiinflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol 2: 1-8.
13. Linden A, Bergendal A, Ullman A, Skoogh BE, Löfdahl CG (1993) Salmeterol, formoterol, and salbutamol in the isolated guinea-pig trachea: differences in maximum relaxant effect and potency but not in functional antagonism. Thorax 48: 547-553.
14. 3 muscarinic receptor inhibits smooth muscle contraction in rabbit trachea without increasing the release of acetylcholine. Br J Phamacol 263: 773-779.
15. 3 adrenoceptor agonists, BRL 37344 and SR 58611A do not induce relaxation of human, sheep and guinea pig airway smooth muscle in vitro. Eur Respir J 7: 1610-1615.
16. Nair SC, Kurumboor SK, Hasegawa JH (1995) Saffron chemoprevention in biology and medicine: a review. Cancer Biother 10: 257-264.
17. 2-adrnoceptors of guinea pig tracheal chains. Phytomed 15: 1038-1045.
18. Popa VT, Somani P, Simon P, and Simon V (1984) The effect of inhaled verapamil on resting bronchial tone and airway constriction by histamine and acetylcholine in normal and asthmatic subjects. Am Rev Respir Dis 130:106-113.
19. Premkumar K, Abraham SK, Santhiya ST, Gopinath PM, Ramesh A (2001) Inhibition of genotoxicity by saffron (Crocus sativus L.) in mice. Drug Chem Tox 24: 421-428.
20. Premkumar K, Abraham SK, Santhiya ST, Ramesh A (2003) Protective effects of saffron (Crocus sativus L.) on genotoxinsinduced oxidative stress in Swiss albino mice. Phytother Res 17: 614-617.
21. Rios JL, Recio MC, Giner RM, Manz S (1996) An update review of saffron and its active constituents. Phytother Res 10: 189-193.
22. Trantilis PA, Tsoupras G, Polissiou M (1995) Determination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatograghy-UV-visible photodiode- array detection-mass spectrometry. J Chromatogr 99: 107-111.
23. Zhang YX, Sugiura M, Saito H, Shoyama Y (1994) Acute effects of Crocus sativus L. on passive avoidance performance in mice. Biol Pharmacol Bull 17: 217-21.