A dual effect of porcine reproductive and respiratory syndrome virus replication on the phosphatidylinositol-3-kinase-dependent Akt pathway

Archives of Virology

Volumn 155, Issue 4, 2010, Pages 571-575

  Zhang, Hanmo ^a   Wang, Xiuqing ^a  

^a SOUTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTERIVIRUS; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUS;

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL; ARTERIVIRUS; ARTICLE; CELL CULTURE; DENDRITIC CELL; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SWINE; VIROLOGY; VIRUS LOAD; VIRUS REPLICATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; CHROMONES; DENDRITIC CELLS; ENZYME INHIBITORS; MORPHOLINES; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SIGNAL TRANSDUCTION; SWINE; VIRAL LOAD; VIRUS REPLICATION;

EID: 77950602315     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-010-0611-6     Document Type: Article

References (20)

1. Brazil DP, Yang ZZ, Hemmings BA (2004) Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29: 233-242.
2. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
3. Chugh P, Bradel-Tretheway B, Monteiro-Filho CM, Planelles V, Maggirwar SB, Dewhurst S, Kim B (2008) Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. Retrovirology 5: 11.
4. Costers S, Lefebvre DJ, Delputte PL, Nauwynck HJ (2008) Porcine reproductive and respiratory syndrome virus modulates apoptosis during replication in alveolar macrophages. Arch Virol 153: 1453-1465.
5. Dhand R, Hiles I, Panayotou G, Roche S, Fry MJ, Gout I, Totty NF, Truong O, Vicendo P, Yonezawa K et al (1994) PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J 13: 522-533.
6. Ehrhardt C, Marjuki H, Wolff T, Nurnberg B, Planz O, Pleschka S, Ludwig S (2006) Bivalent role of the phosphatidylinositol-3-kinase (PI3 K) during influenza virus infection and host cell defence. Cell Microbiol 8: 1336-1348.
7. Ehrhardt C, Wolff T, Pleschka S, Planz O, Beermann W, Bode JG, Schmolke M, Ludwig S (2007) Influenza A virus NS1 protein activates the PI3 K/Akt pathway to mediate antiapoptotic signaling responses. J Virol 81: 3058-3067.
8. Flores-Mendoza L, Silva-Campa E, Resendiz M, Osorio FA, Hernandez J (2008) Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production. Clin Vaccine Immunol 15: 720-725.
9. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C (2003) PI3K/Akt and apoptosis: size matters. Oncogene 22: 8983-8998.
10. Guiducci C, Ghirelli C, Marloie-Provost MA, Matray T, Coffman RL, Liu YJ, Barrat FJ, Soumelis V (2008) PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med 205: 315-322.
11. Halasz P, Holloway G, Turner SJ, Coulson BS (2008) Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield. J Virol 82: 148-160.
12. Vincent IE, Carrasco CP, Herrmann B, Meehan BM, Allan GM, Summerfield A, McCullough1 KC (2003) Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus. J Virol 77: 13288-13300.
13. Kaur S, Sassano A, Joseph AM, Majchrzak-Kita B, Eklund EA, Verma A, Brachmann SM, Fish EN, Platanias LC (2008) Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. J Immunol 181: 7316-7323.
14. Lee SM, Kleiboeker SB (2007) Porcine reproductive and respiratory syndrome virus induces apoptosis through a mitochondria-mediated pathway. Virology 365: 419-434.
15. Loving CL, Brockmeier SL, Sacco RE (2007) Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology 120: 217-229.
16. Mannova P, Beretta L (2005) Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replication. J Virol 79: 8742-8749.
17. Saeed MF, Kolokoltsov AA, Freiberg AN, Holbrook MR, Davey RA (2008) Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus. PLoS pathog 4: e1000141.
18. Shin YK, Liu Q, Tikoo SK, Babiuk LA, Zhou Y (2007) Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation. J Gen Virol 88: 942-950.
19. Soares JA, Leite FG, Andrade LG, Torres AA, De Sousa LP, Barcelos LS, Teixeira MM, Ferreira PC, Kroon EG, Souto-Padron T, Bonjardim CA (2009) Activation of the PI3 K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication. J Virol 83: 6883-6899.
20. Wang X, Eaton M, Mayer M, Li H, He D, Nelson E, Christopher-Hennings J (2007) Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability. Arch Virol 152: 289-303.