Online measurement of particle size distribution during crystallization using ultrasonic spectroscopy

Chemical Engineering Science

Volumn 65, Issue 10, 2010, Pages 3072-3079

  Shukla, Abhishek ^a   Prakash, Anand ^a   Rohani, Sohrab ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Crystallization; Particle size distribution; Particulate processes; Pharmaceuticals; Powder technology; Ultrasonic attenuation spectroscopy

Indexed keywords

ACOUSTIC VELOCITY; CALIBRATION PROCEDURE; DECONVOLUTION ALGORITHM; GRAPHIC USER INTERFACE; INERT PARTICLE; ISOPROPANOL-WATER; LASER DIFFRACTIONS; LOW-ANGLE SCATTERING; MODEL-BASED; OFFLINE; ON-LINE MEASUREMENT; PARACETAMOL; PARTICLE GROWTH; PARTICULATE PROCESS; POWDER TECHNOLOGY; PROBE GEOMETRY; REAL-TIME DATA ACQUISITION; SOLUTION PROPERTY; ULTRASONIC ATTENUATION SPECTROSCOPY; ULTRASONIC SPECTROSCOPY;

ACOUSTIC WAVE VELOCITY MEASUREMENT; CRYSTALLIZATION; DECONVOLUTION; DRUG PRODUCTS; GRAIN BOUNDARIES; PARTICLE SIZE; SIZE DISTRIBUTION; SPECTRUM ANALYSIS; ULTRASONIC WAVES; ULTRASONICS;

PARTICLE SIZE ANALYSIS;

EID: 77950594957     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2010.01.034     Document Type: Article

References (26)

1. Alizadeh-Khaivi, S., 2002. Ultrasonic measurement techniques in slurries. M.E.Sc Thesis, University of Western Ontario.
2. Allegra J.R., and Hawley S.A. Attenuation of sound in suspensions and emulsions. Journal of the Acoustical Society of America 51 (1972) 1545-1564
3. Ament W.S. Sound propagation in gross mixtures. Journal of the Acoustical Society of America 25 (1953) 638-641
4. Barthe S.C., Grover M.A., and Rousseau R.W. Observation of polymorphic change through analysis of fbrm data: transformation of paracetamol from form ii to form i. Crystal Growth and Design 8 9 (2008) 3316-3322
5. Di Martino P., Conflant P., Drache M., Huvenne J.-P., and Guyot-Hermann A.-M. Preparation and physical characterization of forms ii and iii of paracetamol. Journal of Thermal Analysis and Calorimetry 48 3 (1997) 447-458
6. In: Dukhin A.S., and Goetz P.J. (Eds). Ultrasound for Characterizing Colloids-Particle Sizing, Zeta Potential, Rheology (Studies in Interface Science, vol. 15 (2002), Elsevier, Boston
7. Epstein P.S., and Carhart R.R. The absorption of sound in suspensions and emulsions. I. Water fog in air. Journal of the Acoustical Society of America 25 (1941) 553
8. Gibson R.L., and Toksoz M.N. Viscous attenuation of acoustic waves in suspensions. Journal of the Acoustical Society of America 85 (1989) 1925-1934
9. Gron H., Mougin P., Thomas A., White G., Wilkinson D., Hammond R.B., Lai X., and Roberts K.J. Dynamic in-process examination of particle size and crystallographic form under defined conditions of reactant supersaturation as associated with the batch crystallization of monosodium glutamate from aqueous solution. Industrial and Engineering Chemistry Research 42 (2003) 4888-4898
10. Harker A.H., and Temple J.A.G. Velocity and attenuation of ultrasound in suspensions of particles in fluids. Journal of Physics D: Applied Physics 21 (1988) 1576-1588
11. Hay A.E., and Mercer D.G. On the theory of sound scattering and viscous absorption in aqueous suspensions at medium and short wavelength. Journal of the Acoustical Society of America 78 5 (1985) 1761-1771
12. Heath A.R., Fawell P.D., Bahri P.A., and Swift J.D. Estimating average particle size by focused beam reflectance measurement (FBRM). Particle and Particle Systems Characterization 19 (2002) 84-95
13. Hojjati H., and Rohani S. Measurement and prediction of solubility of paracetamol in water-isopropanol solution. Part 1. Measurement and data analysis. Organic Process Research and Development 10 (2006) 1101-1109
14. Lloyd P., and Berry M.V. Wave propagation through an assembly of spheres. Proceedings of the Physical Society 91 (1967) 678-688
15. McClements J.D., Hemar Y., and Herrmann N. Incorporation of thermal overlap effects into multiple scattering theory. Journal of the Acoustical Society of America 105 2 (1999) 915-918
16. Morse P.M., and Ingard K.U. Theoretical Acoustics (1968), McGraw-Hill, New York
17. Mougin P., Wilkinson D., Roberts K.J., and Tweedie R. Characterization of particle size and its distribution during crystallization of organic fine chemical products as measured in situ using ultrasonic attenuation spectroscopy. Journal of the Acoustical Society of America 109 1 (2001) 274-282
18. Nichols G., and Frampton C.S. Physiochemical characterization of the orthorhombic polymorph of paracetamol crystallized from solution. Journal of Pharmaceutical Sciences 87 6 (1998) 684-693
19. Prakash, A., Shukla, A., Rohani, S., 2009. Method and apparatus for ultrasound monitoring of particle size distribution. US Patent Application 61/177029.
20. Richter A., Babick F., and Ripperger S. Polydisperse particle size characterization by ultrasonic attenuation spectroscopy for systems of diverse acoustic contrast in the large particle limit. Journal of the Acoustical Society of America 118 3 (2005) 1394-1405
21. Shukla, A., Prakash, A., Rohani, S., 2010. Particle size distribution measurements in dense suspensions using ultrasonic spectroscopy with an improved model accounting for low angle scattering. AIChE Journal, doi:10.1002/aic.12182.
22. Stolojanu V., and Prakash A. Characterization of slurry systems by ultrasonic techniques. Chemical Engineering Journal 84 (2001) 215-222
23. Taddayon A., and Rohani S. Determination of particle size distribution by par-tec® 100: modelling and experimental results. Particle and Particle Systems Characterization 15 (1998) 127-135
24. Temkin S. Viscous attenuation of sound in dilute suspensions of rigid particles. Journal of the Acoustical Society of America 100 2 (1996) 825-831
25. Waterman P.S., and Truell R. Multiple scattering of waves. Journal of Mathematical Physics 2 (1961) 512-537
26. Wood A.B. A Textbook of Sound (1941), Bell and Sons, London