Intravenous administration of flecainide or propafenone in patients with recent-onset atrial fibrillation does not predict adverse effects during 'pill-in-the-pocket' treatment

Heart

Volumn 96, Issue 7, 2010, Pages 546-549

  Alboni, Paolo ^a   Botto, Giovanni L ^b   Boriani, Giuseppe ^c   Russo, Giovanni ^b   Pacchioni, Federico ^a   Iori, Matteo ^d   Pasanisi, Giovanni ^e   Mancini, Marina ^f   Mariconti, Barbara ^b   Capucci, Alessandro ^g  

^a Ospedale Civile   (Italy)

^b SANT ANNA HOSPITAL   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d S MARIA NUOVA HOSPITAL   (Italy)

^e Delta Hospital   (Italy)

^f Civil Hospital   (Italy)

^g UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FLECAINIDE; PROPAFENONE;

ADULT; AGED; ARTICLE; ATRIOVENTRICULAR BLOCK; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART PALPITATION; HUMAN; HYPOTENSION; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRESYNCOPE; PRIORITY JOURNAL; SINUS ARREST; SYNCOPE;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AMBULATORY CARE; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; DRUG THERAPY, COMBINATION; FLECAINIDE; HOSPITALIZATION; HUMANS; INFUSIONS, INTRAVENOUS; MIDDLE AGED; PROPAFENONE; SELF ADMINISTRATION; TABLETS; YOUNG ADULT;

EID: 77950577970     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2009.187963     Document Type: Article

References (21)

1. Capucci A, Lenzi T, Boriani G, et al. Effectiveness of loading oral flecainide for converting recent-onset atrial fibrillation to sinus rhythm in patients without organic heart disease or with only systemic hypertension. Am J Cardiol 1992;70:69-72.
2. Botto GL, Bonini W, Broffoni T, et al. Regular ventricular rhythms before conversion of recent onset atrial fibrillation to sinus rhythm. Pacing Clin Electrophysiol 1994;17:2114-2117 (Pubitemid 24362959)
3. Capucci A, Boriani G, Botto GL, et al. Conversion of recent onset atrial fibrillation by a single oral loading dose of propafenone or flecainide. Am J Cardiol 1994;74:503-505 (Pubitemid 24269976)
4. Capucci A, Boriani G, Rubino I, et al. A controlled study on oral propafenone versus digoxin plus quinidine in converting recent-onset atrial fibrillation to sinus rhythm. Int J Cardiol 1994;43:305-313 (Pubitemid 24078757)
5. Boriani G, Capucci A, Lenzi T, et al. Propafenone for conversion of recent-onset atrial fibrillation; a controlled comparison between oral loading dose and intravenous administration. Chest 1995;108:355-358
6. Botto GL, Bonini W, Broffoni T, et al. Conversion of recent onset atrial fibrillation with single oral dose of propafenone: is in-hospital admission absolutely necessary? Pacing Clin Electrophysiol 1996;19:1939-1943
7. Azpitarte J, Alvarez M, Baun O, et al. Value of single oral loading dose of propafenone in converting recent onset atrial fibrillation: results of a randomized, double-blind, controlled study. Eur Heart J 1997;18:1649-1654 (Pubitemid 27412422)
8. Boriani G, Biffi M, Capucci A, et al. Oral propafenone to convert recent-onset atrial fibrillation in patients with and without underlying heart disease: a randomized, controlled trial. Ann Intern Med 1997;126:621-625 (Pubitemid 27172189)
9. Botto GL, Capucci A, Bonini W, et al. Conversion of recent onset atrial fibrillation to sinus rhythm using a single loading oral dose of propafenone: comparison of two regimens. Int J Cardiol 1997;58:55-61. (Pubitemid 27047012)
10. Botto GL, Bonini W, Broffoni T, et al. A randomized, crossover, controlled comparison of oral loading versus intravenous infusion of propafenone in recent-onset atrial fibrillation. Pacing Clin Electrophysiol 1998;21:240-244 (Pubitemid 28522887)
11. Blanc JJ, Voinov C. Maarek M for the PARSIFAL Study Group. Comparison of oral loading dose of propafenone and amiodarone for converting recent-onset atrial fibrillation. Am J Cardiol 1999;84:1029-1032
12. Khan IA. Single oral loading dose of propafenone for pharmacological cardioversion of recent onset atrial fibrillation. J Am Coll Cardiol 2001;37:542-547 (Pubitemid 32147267)
13. Capucci A, Villani GQ, Piepoli MF. Reproducible efficacy of loading oral propafenone in restoring sinus rhythm in patients with paroxysmal atrial fibrillation. Am J Cardiol 2003;92:1345-1347 (Pubitemid 37431150)
14. Alboni P, Botto GL, Baldi N, et al. Outpatient treatment of recent onset atrial fibrillation with the "pill-in-the-pocket" approach. N Engl J Med 2004;351:2384-2391
15. Fuster V, Rydén LE, Cannom DS, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology for practice guidelines (writing committee to revise the 2001 guidelines for the management of patients with atrial fibrillation). Eur Heart J 2006;27:1979-2030.
16. Haefeli EW, Vozeh S, Ha HR, et al. Comparison of the pharmacodynamic effects of intravenous and oral propafenone. Clin Pharmacol Ther 1990;48:245-254 (Pubitemid 20323650)
17. Falk RH, Fogel RI. Flecainide. J Cardiovasc Electrophysiol 1994;5:964-981
18. Alp NJ, Bell JA, Shahi M. Randomised double blind trial of oral versus intravenous flecainide for the conversion of acute atrial fibrillation. Heart 2000;84:37-40. (Pubitemid 30429218)
19. Frabetti L, Marchesini B, Capucci A, et al. Antiarrhythmic efficacy of propafenone: evaluation of effective plasma levels following single and multiple doses. Eur J Clin Pharmacol 1986;30:665-667 (Pubitemid 16018944)
20. Capucci A, Boriani G, Marchesini B, et al. Minimal effective concentration values of propafenone and 5-hydroxy-propafenone in acute and chronic therapy. Cardiovasc Drug Ther 1990;4:281-287 (Pubitemid 20108761)
21. Boriani G, Strocchi E, Capucci A, et al. Flecainide: evidence of non-linear kinetics. Eur J Clin Pharmacol 1991;41:57-59