Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model

Medical Mycology

Volumn 48, Issue 3, 2010, Pages 491-497

  Ghannoum, M A ^a,b   Long, L ^a   Kim, H G ^a   Cirino, A J ^a   Miller, A R ^a   Mallefet, P ^c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c Department of Toxicology   (Switzerland)

Author keywords

Dermatomycoses; Guinea pig; Imidazoles; Terbinafine; Treatment outcome

Indexed keywords

ANTIFUNGAL AGENT; LANOCONAZOLE; LULICONAZOLE; TERBINAFINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DERMATOMYCOSIS; DRUG EFFICACY; GUINEA PIG; HAIR ANALYSIS; MALE; NONHUMAN; SCANNING ELECTRON MICROSCOPY; TRICHOPHYTON MENTAGROPHYTES;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIFUNGAL AGENTS; DERMATOMYCOSES; DISEASE MODELS, ANIMAL; GUINEA PIGS; IMIDAZOLES; MALE; NAPHTHALENES; TREATMENT OUTCOME; TRICHOPHYTON;

ANIMALIA; ARTHRODERMA BENHAMIAE; CAVIA; FUNGI;

EID: 77950558508     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693780903373811     Document Type: Article

References (14)

1. Weitzman I, Summerbell RC. The dermatophytes. Clin Microbiol Rev 1995; 8: 240-259.
2. Hossain MA, Ghannoum MA. New developments in chemotherapy for non-invasive fungal infections. Expert Opin Investig Drugs 2001; 10: 1501-1511. (Pubitemid 32717330)
3. Tosti A, Piraccini BM, Stinchi C, Colombo MD. Relapses of onychomycosis after successful treatment with systemic antifungals: a three-year follow-up. Dermatology 1998; 197: 162-166. (Pubitemid 28395845)
4. McClellan KJ, Wiseman LR, Markham A. Terbinafi ne: an update of its use in superfi cial mycoses. Drugs 1999; 58: 179-202. (Pubitemid 29373896)
5. Niwano Y, Tabuchi T, Kanai K, et al. Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent. Antimicrob Agents Chemother 1995; 39: 2353-2355.
6. Niwano Y, Kuzuhara N, Kodama H, et al. In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother 1998; 42: 967-970. (Pubitemid 28216395)
7. Ghannoum MA, Hossain MA, Long L, et al. Evaluation of antifungal effi cacy in an optimized animal model of Trichophyton mentagrophytes- dermatophytosis. J Chemother 2004; 16: 139-144. (Pubitemid 38756945)
8. Treiber A, Pitterman W, Schuppe H. Efficacy testing of antimycotic prophylactics in an animal model. Int J Hyg Environ Health 2001; 204: 239-243. (Pubitemid 34087355)
9. Petranyi G, Leitner I, Mieth H. The "hair root invasion test", a semiquantitative method for experimental evaluation of antimycotics in guinea-pigs. Sabouraudia 1982; 20: 101-108. (Pubitemid 12056150)
10. Hawser SP, Douglas J. Biofi lm formation by Candida species on the surface of catheter materials in vitro. Infect Immun 1994; 62: 915-921.
11. Ghannoum MA, Welshenbaugh A, Imamura Y, et al. Comparison of the in vitro activity of terbinafi ne and lanoconazole against dermatophytes. Mycoses 2009; [Epub ahead of print].
12. Ryder NS. Terbinafi ne: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol 1992; 126: 2-7.
13. Sud IJ, Feingold DS. Mechanisms of action of the antimycotic imidazoles. J Invest Dermatol 1981; 76: 438-441.
14. Sigurgeirsson B, Olafsson JH, Steinsson JP, et al. Long-term effectiveness of treatment with terbinafi ne vs itraconazole in onychomycosis: a 5-year blinded prospective follow-up study. Arch Dermatol 2002; 138: 353-357. (Pubitemid 34226333)