Implications of the HIV-1 Rev dimer structure at 3.2 Å resolution for multimeric binding to the Rev response element

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 13, 2010, Pages 5810-5814

  DiMattia, Michael A ^a,b   Watts, Norman R ^b   Stahl, Stephen J ^b   Rader, Christoph ^c   Wingfield, Paul T ^b   Stuart, David I ^a   Steven, Alasdair C ^b   Grimes, Jonathan M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Crystal structure; Fab cocrystallization; Nuclear export; Posttranscriptional regulation; Ribonucleoprotein structure

Indexed keywords

DIMER; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOMER; PROTEIN SUBUNIT; REV PROTEIN; VIRUS RNA;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; DIMERIZATION; DNA RESPONSIVE ELEMENT; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ANTIBODIES, MONOCLONAL; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GENES, ENV; HIV ANTIBODIES; HIV-1; IMMUNOGLOBULIN FAB FRAGMENTS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; REV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77950539375     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914946107     Document Type: Article

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