Drugs with narrow therapeutic index as indicators in the risk management of hospitalised patients

Pharmacy Practice

Volumn 8, Issue 1, 2010, Pages 50-55

  Blix, Hege S ^a,b   Viktil, Kirsten K ^c   Moger, Tron A ^b   Reikvam, Aasmund ^c  

^a LOVISENBERG DIAKONALE HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Clinical pharmacy information systems; Drug toxicity; Inpatients; Norway

Indexed keywords

AMINOGLYCOSIDE; CARBAMAZEPINE; CYCLOSPORIN A; DIGITOXIN; DIGOXIN; FLECAINIDE; LITHIUM; PHENOBARBITAL; PHENYTOIN; RIFAMPICIN; THEOPHYLLINE; WARFARIN;

ADOLESCENT; ADULT; AGED; ANAMNESIS; ARTICLE; CLINICAL PHARMACY; CONTROLLED STUDY; DIABETES MELLITUS; DOSE TIME EFFECT RELATION; DRUG INDUCED DISEASE; DRUG INTERACTION; DRUG MONITORING; DRUG SAFETY; FEMALE; HEART FAILURE; HOSPITAL PATIENT; HUMAN; INFORMATION PROCESSING; INTERNAL MEDICINE; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NARROW THERAPEUTIC INDEX; NORWAY; OPTIMAL DRUG DOSE; PARAMETERS OF MEASUREMENT AND ANALYSIS; PREDICTOR VARIABLE; RHEUMATOLOGY; RISK ASSESSMENT; RISK MANAGEMENT; TEAMWORK;

EID: 77950524546     PISSN: None     EISSN: 18863655     Source Type: Journal    
DOI: 10.4321/S1886-36552010000100006     Document Type: Article

References (18)

1. Ernst FR, Grizzle AJ. Drug-related morbidity and mortality: updating the cost-of-illness model. J Am Pharm Assoc. 2001;41:192-199.
2. Winterstein AG, Sauer BC, Hepler CD, Poole C. Preventable drug-related hospital admissions. Ann Pharmacother. 2002;36:1238-1248.
3. Patel P, Zed PJ. Drug-related visits to the emergency department: how big is the problem? Pharmacotherapy. 2002;22:915-923.
4. Goodman & Gilman's. The Pharmacological Basis of Therapeutics. 11. Ed. Chapter 1 Pharmacokinetics and Pharmacodynamics. The McGraw-Hill Companies, Inc. (ISBN:0-07-142280-3), 2005.
5. Budnitz DS, Shehab N, Kegler SR, Richards CL. Medication use leading to emergency department visits for adverse drug events in older adults. Ann Intern Med. 2007;147:755-765.
6. MDRD calculator. National Kidney Foundation 2006. http://www.kidney.org/ professionals/kdoqi/gfr-calculator.cfm (last accessed 2009 May 22).
7. WHO Collaborating Centre for Drug Statistics Methodology. ATC Index with DDDs 2006. Oslo: WHO Collaborating Centre, 2005.
8. van Mil JW, Westerlund LO, Hersberger KE, Schaefer MA. Drug-related problem classification systems. Ann Pharmacother. 2004;38:859-867.
9. Pharmaceutical Care Network Europe (PCNE). http//www.pcne.org/) (last accessed 2009 Dec.8).
10. Blix HS, Viktil KK, Reikvam A, Moger TA, Hjemaas BJ, Pretsch P, Vraalsen TF, Walseth EK. The majority of hospitalised patients have drug-related problems: results from a prospective study in general hospitals. Eur J Clin Pharmacol. 2004;60:651-658.
11. Blix HS, Viktil KK, Moger TA, Reikvam A. Characteristics of drug-related problems discussed by hospital pharmacists in multidisciplinary teams. Pharm World Sci. 2006;28:152-158.
12. Norwegian prescription database, NorPD. http://www.norpd.no/ (last accessed 2009 May 22).
13. George J, Munro K, McCaig D, Stewart D. Risk factors for medication misadventure among residents in sheltered housing complexes. Br J Clin Pharmacol. 2007;63:171-176.
14. Viktil KK, Blix HS, Moger TA, Reikvam A. Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems. Br J Clin Pharmacol. 2007;63:187-195.
15. Blix HS, Viktil KK, Moger TA, Reikvam A. Use of renal risk drugs in hospitalized patients with impaired renal function--an underestimated problem? Nephrol Dial Transplant. 2006;21:3164-3171.
16. Björkman IK, Sanner MA, Bernsten CB. Comparing 4 classification systems for drug-related problems: processes and functions. Res Social Adm Pharm. 2008;4:320-331.
17. Blix HS, Viktil KK, Moger TA, Reikvam A. Risk of drug-related problems for various antibiotics in hospital: assessment by use of a novel method. Pharmacoepidemiol Drug Saf. 2008;8:834-841.
18. Donyai P, O'Grady K, Jacklin A, Barber N, Franklin BD. The effects of electronic prescribing on the quality of prescribing. Br J Clin Pharmacol. 2008;65:230-237