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Volumn 397, Issue 5, 2010, Pages 1121-1131

Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch

Author keywords

DNA architecture; Growth inhibition; Rexinoid; RXR; Tetramer

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 9; CYCLIN D1; DNA; GENE PRODUCT; PA 452; PROTEIN BTG2; RETINOID X RECEPTOR; RETINOID X RECEPTOR ANTAGONIST; SR 11345; UNCLASSIFIED DRUG;

EID: 77950521484     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.02.030     Document Type: Article
Times cited : (18)

References (29)
  • 2
    • 0035962669 scopus 로고    scopus 로고
    • Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription
    • Dilworth F.J., Chambon P. Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription. Oncogene 2001, 20:3047-3054.
    • (2001) Oncogene , vol.20 , pp. 3047-3054
    • Dilworth, F.J.1    Chambon, P.2
  • 3
    • 0030953793 scopus 로고    scopus 로고
    • The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state
    • Kersten S., Gronemeyer H., Noy N. The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state. J. Biol. Chem. 1997, 272:12771-12777.
    • (1997) J. Biol. Chem. , vol.272 , pp. 12771-12777
    • Kersten, S.1    Gronemeyer, H.2    Noy, N.3
  • 5
    • 0028887017 scopus 로고
    • Role of ligand in retinoid signaling. 9-cis-Retinoic acid modulates the oligomeric state of the retinoid X receptor
    • Kersten S., Pan L., Chambon P., Gronemeyer H., Noy N. Role of ligand in retinoid signaling. 9-cis-Retinoic acid modulates the oligomeric state of the retinoid X receptor. Biochemistry 1995, 34:13717-13721.
    • (1995) Biochemistry , vol.34 , pp. 13717-13721
    • Kersten, S.1    Pan, L.2    Chambon, P.3    Gronemeyer, H.4    Noy, N.5
  • 6
    • 0028786255 scopus 로고
    • On the role of ligand in retinoid signaling: positive cooperativity in the interactions of 9-cis retinoic acid with tetramers of the retinoid X receptor
    • Kersten S., Pan L., Noy N. On the role of ligand in retinoid signaling: positive cooperativity in the interactions of 9-cis retinoic acid with tetramers of the retinoid X receptor. Biochemistry 1995, 34:14263-14269.
    • (1995) Biochemistry , vol.34 , pp. 14263-14269
    • Kersten, S.1    Pan, L.2    Noy, N.3
  • 7
    • 0033855471 scopus 로고    scopus 로고
    • Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix
    • Gampe R.T., Montana V.G., Lambert M.H., Wisely G.B., Milburn M.V., Xu H.E. Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix. Genes Dev. 2000, 14:2229-2241.
    • (2000) Genes Dev. , vol.14 , pp. 2229-2241
    • Gampe, R.T.1    Montana, V.G.2    Lambert, M.H.3    Wisely, G.B.4    Milburn, M.V.5    Xu, H.E.6
  • 9
    • 0030669764 scopus 로고    scopus 로고
    • The tetramerization region of the retinoid X receptor is important for transcriptional activation by the receptor
    • Kersten S., Reczek P.R., Noy N. The tetramerization region of the retinoid X receptor is important for transcriptional activation by the receptor. J. Biol. Chem. 1997, 272:29759-29768.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29759-29768
    • Kersten, S.1    Reczek, P.R.2    Noy, N.3
  • 12
    • 0032006028 scopus 로고    scopus 로고
    • Beyond tamoxifen: the retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma
    • Bischoff E.D., Gottardis M.M., Moon T.E., Heyman R.A., Lamph W.W. Beyond tamoxifen: the retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma. Cancer Res. 1998, 58:479-484.
    • (1998) Cancer Res. , vol.58 , pp. 479-484
    • Bischoff, E.D.1    Gottardis, M.M.2    Moon, T.E.3    Heyman, R.A.4    Lamph, W.W.5
  • 13
    • 0037112520 scopus 로고    scopus 로고
    • The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice
    • Wu K., Zhang Y., Xu X.C., Hill J., Celestino J., Kim H.T., et al. The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice. Cancer Res. 2002, 62:6376-6380.
    • (2002) Cancer Res. , vol.62 , pp. 6376-6380
    • Wu, K.1    Zhang, Y.2    Xu, X.C.3    Hill, J.4    Celestino, J.5    Kim, H.T.6
  • 14
    • 0034326254 scopus 로고    scopus 로고
    • Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin)
    • Agarwal V.R., Bischoff E.D., Hermann T., Lamph W.W. Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin). Cancer Res. 2000, 60:6033-6038.
    • (2000) Cancer Res. , vol.60 , pp. 6033-6038
    • Agarwal, V.R.1    Bischoff, E.D.2    Hermann, T.3    Lamph, W.W.4
  • 15
    • 0036124124 scopus 로고    scopus 로고
    • Phase 1 and 2 trial of bexarotene gel for skin-directed treatment of patients with cutaneous T-cell lymphoma
    • Breneman D., Duvic M., Kuzel T., Yocum R., Truglia J., Stevens V.J. Phase 1 and 2 trial of bexarotene gel for skin-directed treatment of patients with cutaneous T-cell lymphoma. Arch. Dermatol. 2002, 138:325-332.
    • (2002) Arch. Dermatol. , vol.138 , pp. 325-332
    • Breneman, D.1    Duvic, M.2    Kuzel, T.3    Yocum, R.4    Truglia, J.5    Stevens, V.J.6
  • 16
    • 0034999546 scopus 로고    scopus 로고
    • Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma
    • Duvic M., Martin A.G., Kim Y., Olsen E., Wood G.S., Crowley C.A., Yocum R.C. Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma. Arch. Dermatol. 2001, 137:581-593.
    • (2001) Arch. Dermatol. , vol.137 , pp. 581-593
    • Duvic, M.1    Martin, A.G.2    Kim, Y.3    Olsen, E.4    Wood, G.S.5    Crowley, C.A.6    Yocum, R.C.7
  • 17
    • 0037445123 scopus 로고    scopus 로고
    • Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer
    • Esteva F.J., Glaspy J., Baidas S., Laufman L., Hutchins L., Dickler M., et al. Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer. J. Clin. Oncol. 2003, 21:999-1006.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 999-1006
    • Esteva, F.J.1    Glaspy, J.2    Baidas, S.3    Laufman, L.4    Hutchins, L.5    Dickler, M.6
  • 18
    • 20244375856 scopus 로고    scopus 로고
    • The retinoid X receptor-selective retinoid, LGD1069, down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk: implications for molecular-based chemoprevention
    • Kong G., Kim H.T., Wu K., DeNardo D., Hilsenbeck S.G., Xu X.C., et al. The retinoid X receptor-selective retinoid, LGD1069, down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk: implications for molecular-based chemoprevention. Cancer Res. 2005, 65:3462-3469.
    • (2005) Cancer Res. , vol.65 , pp. 3462-3469
    • Kong, G.1    Kim, H.T.2    Wu, K.3    DeNardo, D.4    Hilsenbeck, S.G.5    Xu, X.C.6
  • 20
    • 33746898960 scopus 로고    scopus 로고
    • Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein
    • Kawakubo H., Brachtel E., Hayashida T., Yeo G., Kish J., Muzikansky A., et al. Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein. Cancer Res. 2006, 66:7075-7082.
    • (2006) Cancer Res. , vol.66 , pp. 7075-7082
    • Kawakubo, H.1    Brachtel, E.2    Hayashida, T.3    Yeo, G.4    Kish, J.5    Muzikansky, A.6
  • 21
    • 33846697072 scopus 로고    scopus 로고
    • Suppression of mammary carcinoma cell growth by retinoic acid: the cell cycle control gene Btg2 is a direct target for retinoic acid receptor signaling
    • Donato L.J., Suh J.H., Noy N. Suppression of mammary carcinoma cell growth by retinoic acid: the cell cycle control gene Btg2 is a direct target for retinoic acid receptor signaling. Cancer Res. 2007, 67:609-615.
    • (2007) Cancer Res. , vol.67 , pp. 609-615
    • Donato, L.J.1    Suh, J.H.2    Noy, N.3
  • 22
    • 0041522463 scopus 로고    scopus 로고
    • Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors
    • Iwata M., Eshima Y., Kagechika H. Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int. Immunol. 2003, 15:1017-1025.
    • (2003) Int. Immunol. , vol.15 , pp. 1017-1025
    • Iwata, M.1    Eshima, Y.2    Kagechika, H.3
  • 23
    • 0029817636 scopus 로고    scopus 로고
    • Identification of a novel retinoic acid response element in the promoter region of the retinol-binding protein gene
    • Panariello L., Quadro L., Trematerra S., Colantuoni V. Identification of a novel retinoic acid response element in the promoter region of the retinol-binding protein gene. J. Biol. Chem. 1996, 271:25524-25532.
    • (1996) J. Biol. Chem. , vol.271 , pp. 25524-25532
    • Panariello, L.1    Quadro, L.2    Trematerra, S.3    Colantuoni, V.4
  • 24
    • 25144496222 scopus 로고    scopus 로고
    • Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling
    • Donato L.J., Noy N. Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005, 65:8193-8199.
    • (2005) Cancer Res. , vol.65 , pp. 8193-8199
    • Donato, L.J.1    Noy, N.2
  • 25
    • 0038332163 scopus 로고    scopus 로고
    • RAR antagonists diminish the level of DNA binding by the RAR/RXR heterodimer
    • Poujol N., Margeat E., Baud S., Royer C.A. RAR antagonists diminish the level of DNA binding by the RAR/RXR heterodimer. Biochemistry 2003, 42:4918-4925.
    • (2003) Biochemistry , vol.42 , pp. 4918-4925
    • Poujol, N.1    Margeat, E.2    Baud, S.3    Royer, C.A.4
  • 26
    • 0032983330 scopus 로고    scopus 로고
    • Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells
    • Li Y., Hashimoto Y., Agadir A., Kagechika H., Zhang X. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J. Biol. Chem. 1999, 274:15360-15366.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15360-15366
    • Li, Y.1    Hashimoto, Y.2    Agadir, A.3    Kagechika, H.4    Zhang, X.5
  • 27
    • 0029102106 scopus 로고
    • Conformational effects on retinoid receptor selectivity: 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity
    • Dawson M.I., Jong L., Hobbs P.D., Cameron J.F., Chao W.R., Pfahl M., et al. Conformational effects on retinoid receptor selectivity: 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. J. Med. Chem. 1995, 38:3368-3383.
    • (1995) J. Med. Chem. , vol.38 , pp. 3368-3383
    • Dawson, M.I.1    Jong, L.2    Hobbs, P.D.3    Cameron, J.F.4    Chao, W.R.5    Pfahl, M.6
  • 29
    • 6844255855 scopus 로고    scopus 로고
    • Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers
    • Umemiya H., Fukasawa H., Ebisawa M., Eyrolles L., Kawachi E., Eisenmann G., et al. Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J. Med. Chem. 1997, 40:4222-4234.
    • (1997) J. Med. Chem. , vol.40 , pp. 4222-4234
    • Umemiya, H.1    Fukasawa, H.2    Ebisawa, M.3    Eyrolles, L.4    Kawachi, E.5    Eisenmann, G.6


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