G-CSF administration is neuroprotective following transient cerebral ischemia even in the absence of a functional NOS-2 gene

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 4, 2010, Pages 739-743

  Gibson, Claire L ^a,b   Bath, Philip Mw ^b   Murphy, Sean P ^a,b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Focal ischemia; G CSF; Neuroprotection; Nitric oxide; NOS 2

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PERFUSION; CELL LOSS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; GENE DELETION; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; GRANULOCYTE COLONY-STIMULATING FACTOR; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE II; ROTAROD PERFORMANCE TEST;

EID: 77950519158     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.12     Document Type: Article

References (14)

1. Gibson CL, Bath PMW, Murphy SP (2005a) G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 25:431-439 (Pubitemid 40502992)
2. Gibson CL, Jones NC, Prior MJW, Bath PMW, Murphy DP (2005b) G-CSF suppresses edema formation and reduces interleukin-1b expression after cerebral ischemia in mice. J Neuropath Exp Neurol 64:1-7
3. Iadecola C, Zhang F, Casey R, Nagayama M, Ross ME (1997) Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 17:9157-9164 (Pubitemid 27498443)
4. Jones NC, Constantin D, Gibson CL, Prior MJW, Morris PG, Marsden CA, Murphy SP (2004) A detrimental role for nitric oxide synthase-2 in the pathology resulting from acute cerebral injury. J Neuropath Exp Neurol 63:708-720 (Pubitemid 38891087)
5. Komine-Kobayashi M, Zhang N, Liu M, Tanaka R, Hara H, Osaka A, Mochizuki H, Mizuno Y, Urabe T (2006) Neuroprotective effect of recombinant human granulo-cyte-colony stimulating factor in transient focal ischemia of mice. J Cereb Blood Flow Metab 26:402-413 (Pubitemid 43297921)
6. Loihl AK, Asensio V, Campbell IL, Murphy SP (1999a) Expression of nitric oxide synthase (NOS)-2 following permanent focal ischemia and the role of nitric oxide in infarct generation in male, female and NOS-2 gene deficient mice. Brain Res 830:155-164 (Pubitemid 29251722)
7. Loihl AK, Whalen S, Campbell IL, Mudget JS, Murphy SP (1999b) Transcriptional activation following cerebral ischemia in mice of a promoter-deleted NOS-2 gene. J Biol Chem 274:8844-8849 (Pubitemid 29164684)
8. MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson H, Chen H, Mudgett JS (1995) Altered responses to bacterial-infection and endotoxic-shock in mice lacking inducible nitric-oxide synthase. Cell 81:641-650
9. Napieralski JA, Banks RJ, Chesselet MF (1998) Motor and somatosensory deficits following uni-and bilateral lesions of the cortex induced by aspiration or thermo-coagulation in the adult rat. Exp Neurol 154:80-88
10. Rogers DC, Campbell JA, Stretton JL, Mackay KB (1997) Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke 28:2060-2066 (Pubitemid 27459019)
11. Schabitz W-R, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Scholzke MN, Sommer C, Schwab M (2003) Neuroprotective effect of granulocyte-stimulating factor after focal cerebral ischemia. Stroke 34:745-751 (Pubitemid 36307405)
12. Schneider A, Kruger C, Steigleder T, Weber D, Pitzer C, Laage R, Aronowski J, Maurer MH, Gassler N, Mier W, Hasselblatt M, Kollmar R, Schwab S, Sommer C, Bach A, Kuhn H-G, Schabitz W-R (2005) The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 115:2083-2098 (Pubitemid 41134150)
13. Sehara Y, Hayashi T, Deguchi K, Zhang H, Tsuchiya A, Yamashita T, Lukic V, Nagai M, Kamiya T, Abe K (2007) Decreased focal inflammatory response by G-CSF may improve stroke outcome after transient middle cerebral artery occlusion in rats. J Neurosci Res 85:2167-2174 (Pubitemid 47172148)
14. Yager JY, Wright S, Armstrong EA, Jahraus CM, Saucier DM (2006) The influence of aging on recovery following ischemic brain damage. Behav Brain Res 173:171-180 (Pubitemid 44291821)