Homogentisic acid interference in routine urine creatinine determination

Molecular Genetics and Metabolism

Volumn 100, Issue 1, 2010, Pages 103-104

  Loken, Perry R ^a   Magera, Mark J ^a   Introne, Wendy ^b   Tortorelli, Silvia ^a   Gavrilov, Dimitar ^a   Oglesbee, Devin ^a   Rinaldo, Piero ^a   Matern, Dietrich ^a   Raymond, Kimiyo ^a  

^a Mayo Clinic   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Alkaptonuria; Creatinine; Homogentisate 1,2 dioxygenase; Homogentisic acid; Interference; Jaffe reaction

Indexed keywords

CREATININE; HOMOGENTISIC ACID;

ALKAPTONURIA; ARTICLE; AUTOANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; ENZYME CHEMISTRY; HUMAN; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; URINALYSIS;

ALKAPTONURIA; ARTIFACTS; CREATININE; HOMOGENTISIC ACID; HUMANS;

EID: 77950518441     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2010.01.006     Document Type: Article

References (10)

1. Phornphutkul C., Introne W.J., Perry M.B., Bernardini I., Murphey M.D., Fitzpatrick D.L., et al. Natural history of alkaptonuria. N. Engl. J. Med. 347 (2002) 2111-2121
2. Morava E., Kosztolanyi G., Engelke U.F., and Wevers R.A. Reversal of clinical symptoms and radiographic abnormalities with protein restriction and ascorbic acid in alkaptonuria. Ann. Clin. Biochem. 40 (2003) 108-111
3. Wolff J.A., Barshop B., Nyhan W.L., Leslie J., Seegmiller J.E., Gruber H., et al. Effects of ascorbic acid in alkaptonuria: alterations in benzoquinone acetic acid and an ontogenic effect in infancy. Pediatr. Res. 26 (1989) 140-144
4. Anikster Y., Nyhan W.L., and Gahl W.A. NTBC and alkaptonuria. Am. J. Hum. Genet. 63 (1998) 920-921
5. Suzuki Y., Oda K., Yoshikawa Y., Maeda T., and Suzuki T. A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuria. J. Hum. Genet. 44 (1999) 79-84
6. P. Rinaldo, Organic acids, in: N. Blau, M. Duran, K.M. Gibson (Eds.), Laboratory Guide to the Methods in Biochemical Genetics, vol., Springer Verlag, Heidelberg, 2008, pp. 137-170.
7. Moriwaki Y., Yamamoto T., Nasako Y., Ohata H., Takahashi S., Tsutsumi Z., et al. 'Pseudohypouricosuria' in alcaptonuria: homogentisic acid interference in the measurement of urinary uric acid with the uricase-peroxidase reaction. Ann. Clin. Biochem. 36 Pt 4 (1999) 501-503
8. 2-producing reactions. I. The determination of the uric acid concentration. J. Clin. Chem. Clin. Biochem. 14 (1976) 101-107
9. Karon B.S., Daly T.M., and Scott M.G. Mechanisms of dopamine and dobutamine interference in biochemical tests that use peroxide and peroxidase to generate chromophore. Clin. Chem. 44 (1998) 155-160
10. Saenger A.K., Lockwood C., Snozek C.L., Milz T.C., Karon B.S., Scott M.G., and Jaffe A.S. Catecholamine interference in enzymatic creatinine assays. Clin. Chem. 55 (2009) 1732-1736