Normal-phase LC method for simultaneous analysis of pseudophedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramine maleate, and paracetamol in tablet formulations

Saudi Pharmaceutical Journal

Volumn 18, Issue 2, 2010, Pages 103-106

  Al Rimawi, Fuad ^a  

^a AL QUDS UNIVERSITY   (Palestine)

Author keywords

Chlorpheniramine maleate; Dextromethorphan hydrobromide; Paracetamol; Pseudophedrine hydrochloride; Validation

Indexed keywords

CHLORPHENIRAMINE MALEATE; DECONGESTIVE AGENT; DEXTROMETHORPHAN; PARACETAMOL; PSEUDOPHEDRINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DRUG DETERMINATION; DRUG SELECTIVITY; LIQUID CHROMATOGRAPHY; REPRODUCIBILITY; TABLET FORMULATION;

EID: 77950516592     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsps.2010.02.006     Document Type: Article

References (8)

1. Biemer T.A. Simultaneous analysis of acetaminophen, pseudophedrine hydrochloride and chlorpheniramine maleate in a cold tablet using an isocratic, mixed micellar high-performance liquid chromatographic mobile phase. J. Chrom. 410 1 (1987) 206-210
2. Chen Z.L., Zhang L., Wang M., and Huang Y. Simultaneous determination of chlorpheniramine, paracetamol and pseudoephedrine hydrochloride in composite tablets by high performance liquid chromatography. Se Pu 19 3 (2001) 236-238
3. Das Gupta V., and Heble A.R. Quantitation of acetaminophen, chlorpheniramine maleate, dextromethorphen hydrobromide, and phenylpropanolamine hydrochloride in combination using high-performance liquid chromatography. J. Phar. Sci. 73 11 (1984) 1553-1556
4. De Orsi D., Gagliardi L., Bolasco A., and Tonelli D. Simultaneous determination of triprolidine, pseudophedrine, paracetamol and dextromethorphan by HPLC. Chromatographia 43 9-10 (1996) 496-500
5. Milenkova K., Dimitrovska A., Ugrinova L., and Trajkovic-Jolevska S. Simultaneous determination of paracetamol, pseudoephedrine hydrochloride and dextromethorphan hydrobromide in tablets by HPLC. Bullet. Chem. Technol. Macedonia 22 1 (2003) 33-37
6. Murtha J.L., Julian T.N., and Radebaugh G.W. Simultaneous determination of pseudophedrine hydrochloride, chlorpheniramine maleate, and dextromethorphan hydrobromide by second-derivative photodiode array spectroscopy. J. Pharm. Sci. 77 8 (2006) 715-718
7. Patil K.M., Bhoir I.C., Raman B., and Sundaresan M. Concurrent assay of acetaminophen, pseudophedrine, guaifenesin and dextromethorphan in formulations by packed column super-critical fluid chromatography. Ind. J. Pharm. Sci. 63 6 (2001) 468-472
8. United States Pharmacopeia 32, 2009. National Formulary 27, Rockville, MD.