MMP12, lung function, and COPD in high-risk populations

New England Journal of Medicine

Volumn 362, Issue 13, 2010, Pages 1241-1242

  Elkington, Paul T ^a   Cooke, Graham S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; MACROPHAGE ELASTASE; STROMELYSIN; INTERSTITIAL COLLAGENASE;

CHRONIC OBSTRUCTIVE LUNG DISEASE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HIGH RISK POPULATION; HUMAN; LETTER; LUNG FUNCTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; CARDIOVASCULAR DISEASE; DISEASE ASSOCIATION; GENE INTERACTION; LUNG BLOOD VESSEL; PASSIVE SMOKING; ADULT; ASTHMA; CHILD; FORCED EXPIRATORY VOLUME; GENETIC PREDISPOSITION; GENETICS; NOTE; PATHOPHYSIOLOGY; CHROMOSOME 11; GENE; MMP13 GENE; MMP3 GENE; PATHOGENESIS;

ADULT; ASTHMA; CARDIOVASCULAR DISEASES; CHILD; FORCED EXPIRATORY VOLUME; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MATRIX METALLOPROTEINASE 12; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; TOBACCO SMOKE POLLUTION; LINKAGE DISEQUILIBRIUM; MATRIX METALLOPROTEINASE 1; SMOKING;

EID: 77950506153     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1000959     Document Type: Letter

References (3)

1. Hunninghake GM, Cho MH, Tesfaigzi Y, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med 2009;361:2599-608.
2. D'Armiento J, Dalal SS, Okada Y, Berg RA, Chada K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 1992;71:955-61.
3. Ohta Y, Hayashi M, Kanemaru T, Abe K, Ito Y, Oike M. Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production. J Immunol 2008; 180 : 4191-9.