Pemetrexed plus bevacizumab for second-line therapy of non-small-cell lung cancer: The importance of patient selection

Journal of Clinical Oncology

Volumn 28, Issue 8, 2010, Pages

  Araujo, Antonio M ^a,b  

^a PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^b Hospital So Sebastio   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CISPLATIN; DOCETAXEL; GEMCITABINE; PEMETREXED; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; GLUTAMIC ACID DERIVATIVE; GUANINE; MONOCLONAL ANTIBODY;

CANCER COMBINATION CHEMOTHERAPY; CONFOUNDING VARIABLE; HUMAN; LETTER; LUNG NON SMALL CELL CANCER; PATIENT SELECTION; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; SAMPLE SIZE; DRUG RESISTANCE; GENETIC POLYMORPHISM; GENETICS; LUNG TUMOR; NOTE; PATHOLOGY;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG RESISTANCE, NEOPLASM; GLUTAMATES; GUANINE; HUMANS; LUNG NEOPLASMS; PATIENT SELECTION; POLYMORPHISM, GENETIC;

EID: 77950503737     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2009.26.7351     Document Type: Letter

References (7)

1. Scagliotti G, Hanna N, Fossella F, et al: The differential efficacy of pemetrexed according to NSCLC histology: A review of two phase III studies. Oncologist 14:253-263, 2009
2. Hanna N, Shepherd FA, Fossella FV, et al: Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 22:1589-1597, 2004 (Pubitemid 41079796)
3. Sacgliotti G, Parikh P, von Pawel J, et al: Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naïve patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 26:3543-3551, 2008
4. Ciuleanu TE, Brodowicz T, Zielinski C, et al: Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomized, double-blind, phase 3 study. Lancet 24:1432-1440, 2009
5. Sandler A, Gray R, Perry MC, et al: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355:2542-2550, 2006 (Pubitemid 44917502)
6. Reck M, von Pawel J, Zatloukal P, et al: Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAIL. J Clin Oncol 27:1227-1234, 2009
7. Adjei AA, Mandrekar SJ, Dy GK, et al: Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. J Clin Oncol 28:614-619, 2010