Clonality of nodular lesions in liver cirrhosis and chromosomal abnormalities in monoclonal nodules of altered hepatocytes

Histopathology

Volumn 56, Issue 5, 2010, Pages 589-599

  Gong, Li ^a   Li, Yan Hong ^a   Su, Qin ^a,b   Chu, Xia ^a   Zhang, Wei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b CANCER HOSPITAL   (China)

Author keywords

Chromosomal abnormalities; Clonality; Liver cirrhosis; Nodules of altered hepatocytes; Small cell change

Indexed keywords

ANDROGEN RECEPTOR; GENOMIC DNA; PHOSPHOGLYCERATE KINASE;

ADULT; AGED; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME LOSS; CLINICAL ARTICLE; CLONAL VARIATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DISEASE COURSE; DNA EXTRACTION; FEMALE; GENE AMPLIFICATION; GENETIC LINKAGE; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; LASER MICRODISSECTION; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEX CHROMOSOME MOSAICISM; SINGLE NUCLEOTIDE POLYMORPHISM; X CHROMOSOME INACTIVATION;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CHROMOSOME ABERRATIONS; CLONE CELLS; DISEASE PROGRESSION; DNA, NEOPLASM; FEMALE; FOCAL NODULAR HYPERPLASIA; HEPATITIS B, CHRONIC; HEPATOCYTES; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; PRECANCEROUS CONDITIONS;

HEPATITIS B VIRUS;

EID: 77950490900     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2010.03523.x     Document Type: Article

References (31)

1. Bannasch P. Pathogenesis of hepatocellular carcinoma: sequential cellular, molecular, and metabolic changes. In Boyer JL, Ockner PK eds. Progress in liver disease.
2. Anthony PP, Vogel CL, Barker LE. Liver cell dysplasia: a premalignant condition. J. Clin. Pathol. 1973 26 217 223.
3. Watanable S, Okita K, Harada T et al. Morphologic studies of the liver cell dysplasia. Cancer 1983 51 2197 2205.
4. Marchio A, Terris B, Meddeb M et al. Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridisation. Mol. Pathol. 2001 54 270 274.
5. Llovet JM, Chen Y, Wurmbach E et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 2006 131 1758 1767.
6. Nam SW, Park JY, Ramasamy A et al. Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling. Hepatology 2005 42 809 818.
7. Wurmbach E, Chen YB, Khitrov G et al. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 2007 45 938 947.
8. Plentz RR, Park YN, Lechel A et al. Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis. Hepatology 2007 45 968 976.
9. Su Q, Bannasch P. Relevance of hepatic preneoplasia for human hepatocarcinogenesis. Toxicol. Pathol. 2003 31 126 133.
10. Altmann HW. Hepatic neoformations. Pathol. Res. Pract. 1994 190 513 577.
11. Fischer G, Hartmann H, Droese M et al. Histochemical and immunohistochemical detection of putative preneoplastic liver foci in woman after long-term use of oral contraceptives. Virchows Arch. B Cell Pathol. 1986 50 321 337.
12. Hirota N, Hamazaki M, Williams GM. Resistance to iron accumulation and presence of hepatitis B surface antigen in preneoplastic and neoplastic lesions in human haemochromatotic livers. Hepatogastroenterology 1982 29 49 51.
13. Karhunen PJ, Penttila A. Preneoplastic lesions of human liver. Hepatogastroenterology 1987 34 10 15.
14. Deugnier YM, Charalambous P, Le Quilleuc D et al. Preneoplastic significance of hepatic iron-free foci in genetic haemochromatosis: a study of 185 patients. Hepatology 1993 18 1363 1369.
15. Bannasch P, Jahn U-R, Hacker HJ et al. Focal hepatic glycogenosis: a putative preneoplastic lesion associated with neoplasia and cirrhosis in explanted human livers. Int. J. Oncol. 1997 10 261 268.
16. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48900 necropsies. Cancer 1954 7 462 503.
17. Su Q, Benner A, Hofmnn WJ et al. Human hepatic preneoplasia: phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia. Virchows Arch. 1997 431 391 406.
18. Gong L, Zhang W, Su Q. Clonal status of fibrous dysplasia. Pathology 2008 40 392 395.
19. Wang SF, Su Q, Zhu SJ et al. Clonality of multiple uterine leiomyomas. Zhonghua Bing Li Xue Za Zhi 2002 31 107 111.
20. Su Q, Liu Q, Wang SF. Clonality analysis technology based on X chromosome genetic polymorphism and application. Zhonghua Bing Li Xue Za Zhi 2002 31 162 164.
21. Aoki N, Robinson WS. State of hepatitis B viral genomes in cirrhotic and hepatocellular carcinoma nodules. Mol. Biol. Med. 1989 6 395 408.
22. Yasui H, Hino O, Ohtake K et al. Clonal growth of hepatitis B virus-integrated hepatocytes in cirrhotic liver nodules. Cancer Res. 1992 52 6810 6814.
23. Aihara T, Noguchi S, Sasaki Y et al. Clonal analysis of regenerative nodules in hepatitis C virus-induced liver cirrhosis. Gastroenterology 1994 107 1805 1811.
24. Ochiai T, Urata Y, Yamano T et al. Clonal expansion in evolution of chronic hepatitis to hepatocellular carcinoma as seen at an X-chromosome locus. Hepatology 2000 31 615 621.
25. Piao Z, Park YN, Kim H et al. Clonality of large regenerative nodules in liver cirrhosis. Liver 1997 17 251 256.
26. Paradis V, Dargere D, Bonvoust F et al. Clonal analysis of micronodules in virus C-induced liver cirrhosis using laser capture microdissection (LCM) and HUMARA assay. Lab. Invest. 2000 80 1553 1559.
27. Diaz-Cano SJ, Blanes A, Wolfe HJ. PCR techniques for clonality assays. Diagn. Mol. Pathol. 2001 10 24 33.
28. Fialkow PJ. Clonal origin of human tumors. Biochim. Biophys. Acta 1976 458 283 321.
29. Iannaccone PM, Weinberg WC, Berkwits L. A probabilistic model of mosaicism based on the histological analysis of chimaeric rat liver. Development 1987 99 187 196.
30. Nesbitt MN. Chimeras vs X inactivation mosaics: significance of differences in pigment distribution. Dev. Biol. 1974 38 202 207.
31. Ochiai T, Ueda K, Urata Y et al. Clonal analysis of hepatocellular carcinoma. Gan To Kagaku Ryoho 1996 23 182 188.