Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan children

Pediatric Blood and Cancer

Volumn 54, Issue 5, 2010, Pages 670-674

  Gantt, Soren ^a,b   Kakuru, Abel ^c,d   Wald, Anna ^b   Walusansa, Victoria ^c,d   Corey, Lawrence ^b,e   Casper, Corey ^b,e   Orem, Jackson ^c,d  

^a SEATTLE CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UGANDA CANCER INSTITUTE   (Uganda)

^d MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^e Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Children; Epidemic Kaposi sarcoma; HIV; Human herpesvirus 8; Lymphadenopathy

Indexed keywords

BLEOMYCIN; EFAVIRENZ; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NEVIRAPINE; STAVUDINE; TENOFOVIR; VINCRISTINE; ZIDOVUDINE; ANTINEOPLASTIC AGENT; ANTIRETROVIRUS AGENT;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CHILD; CLINICAL FEATURE; DISEASE COURSE; EPIDEMIC; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; KAPOSI SARCOMA; LYMPH NODE; LYMPH NODE BIOPSY; LYMPH NODE METASTASIS; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; PATIENT REFERRAL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT RESPONSE; UGANDA; COMORBIDITY; PATHOLOGY; TREATMENT OUTCOME;

ADOLESCENT; ANTI-RETROVIRAL AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; COMORBIDITY; FEMALE; HERPESVIRUS 8, HUMAN; HIV INFECTIONS; HUMANS; LYMPHATIC METASTASIS; MALE; SARCOMA, KAPOSI; TREATMENT OUTCOME; UGANDA;

EID: 77950478676     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22369     Document Type: Article

References (27)

1. Cancer incidence in five continents, Vol.VIII. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB, Editors. Lyons, France: IARC Scientific Publications; 2002; 1-781. http://www.iacr.com.fr/ci5v8-a.htm
2. Parkin DM,Wabinga H, Nambooze S, et al. AIDS-related cancers in Africa: Maturation of the epidemic in Uganda. AIDS 1999; 13:2563-2570. (Pubitemid 30038035)
3. Beral V, Peterman TA, Berkelman RL, et al. Kaposi's sarcoma among persons with AIDS: A sexually transmitted infection? Lancet 1990;335:123-128.
4. Davies JN, Wilson BA, Knowelden J. Cancer incidence of the African population of Kyadondo (Uganda). Lancet 1962;2:328-330.
5. Taylor JF, Smith PG, Bull D, et al. Kaposi's sarcoma in Uganda: Geographic and ethnic distribution. Br J Cancer 1972;26:483-497.
6. Olweny CL, Kaddumukasa A, Atine I, et al. Childhood Kaposi's sarcoma: Clinical features and therapy. Br J Cancer 1976;33:555-560.
7. Wabinga HR, Parkin DM, Wabwire-Mangen F, et al. Cancer in Kampala, Uganda, in 1989-1991: Changes in incidence in the era of AIDS. Int J Cancer 1993;54:26-36.
8. Wabinga HR, Parkin DM, Wabwire-Mangen F, et al. Trends in cancer incidence in Kyadondo County, Uganda, 1960-1997. Br J Cancer 2000;82:1585-1592.
9. DutzW, StoutAP. Kaposi's sarcoma in infants and children. Cancer 1960;13:684-694.
10. Ziegler JL, Katongole-Mbidde E. Kaposi's sarcoma in childhood: An analysis of 100 cases from Uganda and relationship to HIV infection. Int J Cancer 1996;65:200-203. (Pubitemid 26048915)
11. Davies JN, Lothe F. Kaposi's sarcoma in African children. Acta Union Int Contra Cancrum 1962;18:394-399.
12. Ziegler JL, Templeton AC, Vogel CL. Kaposi's sarcoma: A comparison of classical, endemic, and epidemic forms. Semin Oncol 1984;11:47-52. (Pubitemid 14138419)
13. Patil PS, Elem B, Gwavava NJ, et al. The pattern of paediatric malignancy in Zambia (1980-1989): A hospital-based histopathological study. J Trop Med Hyg 1992;95:124-127.
14. Arkin LM, Cox CM,Kovarik CL. Kaposi's sarcoma in the pediatric population: The critical need for a tissue diagnosis. Pediatr Infect Dis J 2009;28:426-428.
15. Friedman-Kien AE, Laubenstein LJ, Rubinstein P, et al. Disseminated Kaposi's sarcoma in homosexual men. Ann Intern Med 1982;96:693-700. (Pubitemid 12029334)
16. Duprez R, Lacoste V, Briere J, et al. Evidence for a multiclonal origin of multicentric advanced lesions of Kaposi sarcoma. J Natl Cancer Inst 2007;99:1086-1094. (Pubitemid 47241393)
17. Stebbing J, Sanitt A, Nelson M, et al. A prognostic index for AIDS-associated Kaposi's sarcoma in the era of highly active antiretroviral therapy. Lancet 2006;367:1495-1502.
18. Nguyen HQ, Magaret AS, Kitahata MM, et al. Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: Characterizing the predictors of clinical response. AIDS 2008; 22:937-945.
19. Embree J, Bwayo J, Nagelkerke N, et al. Lymphocyte subsets in human immunodeficiency virus type 1-infected and uninfected children in Nairobi. Pediatr Infect Dis J 2001;20:397-403. (Pubitemid 32294748)
20. Wang QJ, Jenkins FJ, Jacobson LP, et al. Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins. Blood 2001;97:2366-2373.
21. Casper C, Wald A, Pauk J, et al. Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with men. J Infect Dis 2002;185:990-993. (Pubitemid 34274444)
22. Hjalgrim H, Askling J, Rostgaard K, et al. Characteristics of Hodgkin's lymphoma after infectious mononucleosis. N Engl J Med 2003;349:1324-1332. (Pubitemid 37186210)
23. Olsen SJ, Chang Y, Moore PS, et al. Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985. AIDS 1998; 12:1921-1925.
24. Mayama S, Cuevas LE, Sheldon J, et al. Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Int J Cancer 1998;77:817-820. (Pubitemid 28378125)
25. Mbulaiteye SM, Pfeiffer RM, Whitby D, et al. Human herpesvirus 8 infection within families in rural Tanzania. J Infect Dis 2003; 187:1780-1785. (Pubitemid 36667889)
26. Rezza G, Dorrucci M, Serraino D, et al. Incidence of Kaposi's sarcoma and HHV-8 seroprevalence among homosexual men with known dates of HIV seroconversion. Italian Seroconversion Study. AIDS 2000;14:1647-1653.
27. Dedicoat M, Vaithilingum M, Newton R. Treatment of Kaposi's sarcoma in HIV-1 infected individuals with emphasis on resource poor settings. Cochrane Database Syst Rev 2003; 3: CD003256. Review. PubMed PMID: 12917957.