Reduced cellular redox status induces 4-hydroxynonenal-mediated caspase 3 activation leading to erythrocyte death during chronic arsenic exposure in rats

Toxicology and Applied Pharmacology

Volumn 244, Issue 3, 2010, Pages 315-327

  Biswas, Debabrata ^a   Sen, Gargi ^a   Biswas Tuli, T ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Arsenic exposure; Caspase 3; Erythrocyte; HNE; Oxidative stress; ROS

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ANTIOXIDANT; ARSENIC; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IMMUNOGLOBULIN G; MEMBRANE PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; 4-HYDROXY-2-NONENAL; ALDEHYDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ARTICLE; CELL DAMAGE; CELL DEATH; CELL ISOLATION; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVATION; ERYTHROCYTE; EXPOSURE; LIFESPAN; MALE; MASS SPECTROMETRY; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; RAT; WESTERN BLOTTING; ANEMIA; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; METABOLISM; OXIDATION REDUCTION REACTION; POLLUTANT; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

RATTUS;

ALDEHYDES; ANEMIA; ANIMALS; ARSENIC; CASPASE 3; ENVIRONMENTAL POLLUTANTS; ENZYME ACTIVATION; ERYTHROCYTES; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDES; TOXICITY TESTS, CHRONIC;

EID: 77950476003     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.01.009     Document Type: Article

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